MADMAX: Precise Measurement of Conformational Changes in Proteins

MADMAX：精确测量蛋白质构象变化

• 批准号: 8230589
• 负责人: LEE MAKOWSKI
• 金额: $ 30.48万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8230589
• 关键词: Advanced Development; Biological Process; Chemicals; Detection; Development; Diagnosis; Disease; Goals; Label; Length; Ligand Binding; Ligands; Measurement; Measures; Mechanics; Membrane Proteins; Methods; Molecular; Motion; Movement; Pathogenesis; Positioning Attribute; Protein Dynamics; Proteins; Resolution; Roentgen Rays; Solutions; System; Techniques; Time; aqueous; base; human disease; macromolecule; millisecond; novel; novel strategies; peptide chemical synthesis; protein folding; protein function; protein structure function; research study; time use; tool; vector

项目成果

Neutron spin-echo studies of hemoglobin and myoglobin: multiscale internal dynamics.

血红蛋白和肌红蛋白的中子自旋回波研究：多尺度内部动力学。

• DOI: 10.1016/j.jmb.2010.01.029
• 发表时间: 2010
• 期刊: Journal of molecular biology
• 影响因子: 5.6
• 作者: Lal,Jyotsana;Fouquet,Peter;Maccarini,Marco;Makowski,Lee
• 通讯作者: Makowski,Lee

Wide-angle X-ray solution scattering for protein-ligand binding: multivariate curve resolution with Bayesian confidence intervals.

用于蛋白质-配体结合的广角 X 射线溶液散射：具有贝叶斯置信区间的多元曲线分辨率。

• DOI: 10.1016/j.bpj.2012.12.019
• 发表时间: 2013
• 期刊: Biophysical journal
• 影响因子: 3.4
• 作者: Minh,DavidDL;Makowski,Lee
• 通讯作者: Makowski,Lee

Visualizing global properties of a molecular dynamics trajectory.

可视化分子动力学轨迹的全局特性。

• DOI: 10.1002/prot.24957
• 发表时间: 2016
• 期刊: Proteins
• 影响因子: 2.9
• 作者: Zhou,Hao;Li,Shangyang;Makowski,Lee
• 通讯作者: Makowski,Lee

Multi-wavelength anomalous diffraction using medium-angle X-ray solution scattering (MADMAX).

• DOI: 10.1016/j.bpj.2012.01.026
• 发表时间: 2012-02
• 期刊: Biophysical journal
• 影响因子: 3.4
• 作者: Lee Makowski;J. Bardhan;David Gore;D. Rodi;Robert F. Fischetti