ANIMAL CARE & HUSBANDRY CORE

动物护理

• 批准号: 8204235
• 负责人: PHILIP N HOWLES
• 金额: $ 12.77万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8204235
• 关键词: Age; Animal Husbandry; Animals; Area; Breeding; Caliber; Communication; Diet Monitoring; Genetic; Health; Health Status; Housing; Human Resources; Institution; Laboratory Animal Medicine; Medicine; Metabolic; Monitor; Mus; Nutritional; Phenotype; Procedures; Protocols documentation; Quarantine; Reporting; Research; Research Personnel; Schedule; Services; Testing; Universities; Venous blood sampling; Weight Gain; animal care; satisfaction

Central to the accuracy and reliability of any animal study is the caliber and consistency of the animals' husbandry and health monitoring. The importance of these matters is heightened in the context of a service center such as the UC MMPC, which receives mice with a wide variety of genetic and/or nutritional challenges from many different investigators and institutions. Also central to MMPC function and investigator satisfaction is efficient and effective communication of information between LAMS facility personnel at the investigator and Center institutions so as to expedite the transfer of investigators' animals for phenotype analysis in a timely manner. Thus Core B, Animal Care and Husbandry, remains a critical part of the UC MMPC, as it has been since the Center's inception in 2001. There are three broad, long-range aims of this Core: Specific Aim 1: To coordinate and facilitate the transfer of animals from investigator's institutions to the University of Cincinnati Lab Animal Medicine Services (LAMS) Department and ultimately the UC MMPC housing area. Standard Operating Procedures of the UC MMPC and LAMS department for receiving animals from outside institutions are educated to our users. Specific Aim 2: To communicate with the UC LAMS and veterinary staff to select appropriate quarantine protocols for investigator mice upon receipt, and to jointly monitor the health and husbandry of the mice during the transition period from arrival to incorporation into the MMPC. The Animal Care and Husbandry Core also coordinates with the investigator to return (or destroy) animal carcasses after terminal procedures. Specific Aim 3: The Animal Care and Husbandry Core will continue to provide specialized husbandry service prior to delivery of mice to service Cores, as requested by specific investigators or Core Directors. These include administering specialized diets and monitoring weight gain, phlebotomy service for multiple tests, breeding service of mice such as when age-sensitive phenotypes are expected, and purchasing control mice from standard suppliers when necessary.

任何动物研究的准确性和可靠性的核心是动物饲养和健康监测的才能和一致性。这些问题的重要性在服务中心（例如UC MMPC）的背景下提高了，该服务中心从许多不同的研究者和机构中接受了各种遗传和/或营养挑战的小鼠。 MMPC功能和调查员满意度的中心是LAMS设施人员之间信息的有效沟通 研究人员和中心机构以及时加快研究人员的动物进行表型分析的转移。因此，自2001年中心成立以来，核心B，动物护理和饲养仍然是UC MMPC的关键部分。该核心有三个广泛的，长距离的目标： 具体目的1：协调和促进动物从研究人员的机构转移到辛辛那提大学实验室动物医学服务部（LAMS）系，最终是UC MMPC住房区。 UC MMPC和LAMS部门的标准操作程序向我们的用户提供了教育。 具体目的2：与UC LAM和兽医进行交流，以在收到后为研究者小鼠选择适当的隔离协议，并在从到达到MMPC中的过渡期内共同监测小鼠的健康和饲养。动物护理和饲养核心还与研究人员协调终止程序后返回（或销毁）动物尸体。 特定目标3：按照特定的调查员或核心董事的要求，在将小鼠交付给服务核心之前，动物护理和饲养核心将继续提供专门的饲养服务。 其中包括管理专业饮食和监测体重增加，用于多种测试的静脉切开术，预期年龄敏感表型等小鼠的繁殖服务以及必要时从标准供应商那里购买控制小鼠。