NICHD Materal Fetal Medicine Units Network

描述(由申请人提供)：阿拉巴马大学伯明翰分校(UAB)母胎医学部提交此申请，以续签我们作为尤尼斯·肯尼迪·施莱弗NICHD母胎医学部(MFMU)网络临床中心的参与。我们展示了我们中心目前出色的表现，并明确了新的属性和计划，以增加我们对网络调查临床产科主要问题的贡献，特别是与低出生体重、早产和妊娠医学并发症相关的问题。我们拥有完善的研究基础设施和在MFMU网络内外进行相关临床试验的丰富经验。作为过去四个五年周期的网络参与中心，UAB在指导委员会和小组委员会层面为网络提供研究指导方面发挥了领导作用，有效地促进了网络试验的进行，并显著参与了这些试验产生的数据的介绍和发布。在该网络历史上的28个临床中心中，一名UAB研究员首次撰写了目前180篇MFMU网络出版物中的约25%。在全国会议上总共360次网络发言中，一名UAB调查员出席了22%的会议。UAB调查小组的现任成员在积极参与或支持MFMU研究项目方面积累了超过150人的经验。医学博士艾伦·蒂塔和医学博士威廉·安德鲁斯将继续担任首席调查员和候补研究员。该小组包括两名以前的现场PI和5名曾担任网络协议主席或小组委员会成员的成员。最后，根据患者招募、遵守方案、保留和随访、数据质量和研究启动时间，MFMU网络数据协调中心以77%(10/13)的时间将我们排在参与中心中的第一或第二(总体第一，58%的时间)。如果在这次竞争性续签申请中成功，我们将调动我们的设施、设备、数据管理系统(包括我们的电子围产期记录系统)、招聘资源、强大的调查团队和训练有素的人员，以开发和实施MFMU网络协议和项目。我们相信，作为NICHD MFMU网络中心，我们将在未来五年保持良好的竞争地位。

DESCRIPTION (provided by applicant): The Maternal-Fetal Medicine Division of the University of Alabama at Birmingham (UAB) submits this application to renew our participation as a clinical center of the Eunice Kennedy Shriver NICHD Maternal- Fetal Medicine Units (MFMU) Network. We present our center's current record of exceptional performance and specify new attributes and plans to increase our contributions to the Network's goals of investigating major problems in clinical obstetrics, particularly those related to low birth weight, prematurity, and medical complications of pregnancy. We have a well-established research infrastructure and extensive experience in performing relevant clinical trials both within and outside the MFMU Network. As a Network participating center over the last four 5-year cycles, UAB has played a leadership role in providing research direction for the Network at the Steering Committee and sub-committee levels, contributed efficiently to the conduct of Network trials, and participated significantly in the presentation and publication of data generated by these trials. Among 28 clinical centers in the history of the Network, a UAB investigator has first-authored approximately 25% of 180 current MFMU Network publications. Of 360 total Network presentations at national meetings, a UAB investigator presented 22%. Current members of the UAB investigative team have accumulated well over 150 person-years experience of active participation in or support of MFMU research projects. Alan Tita, MD, PhD and William Andrews, PhD, MD will continue as Principal Investigator and Alternate. The team includes two previous site PI's and 5 members who have served as Network protocol chairpersons or Subcommittee members. Finally on the basis of patient recruitment, protocol adherence, retention and follow-up, data quality, and study start-up time, the MFMU Network Data Coordinating Center ranked us #1 or #2 among the participating centers 77% (10/13) of the time (#1 overall, 58% of the time). If successful in this competitive renewal application, we will marshal our facilities, equipment, data management systems (including our electronic perinatal record system), recruitment resources, strong investigative team and trained personnel even more to develop and implement MFMU Network protocols and projects. We believe that we remain well positioned for competitive renewal as an NICHD MFMU Network center for the next five years.