The Developmental Origins of Disease and Deterioration in Old Age

老年疾病和恶化的发育起源

基本信息

批准号：
8134876
负责人：
David J Barker
金额：
$ 16.72万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8134876
关键词：
Accounting Admission activity Adult Affect Age Age at Menarche American Animals Behavior Biochemical Biological Process Birth Birth Records Blood specimen Body Size Body mass index Breast Feeding Cardiovascular Diseases Cardiovascular system Censuses Cessation of life Child Childhood Chronic Disease Cohort Studies Competence Conceptions Coronary heart disease Country DNA Data Data Set Deterioration Development Diabetes Mellitus Diet Disease Economic Conditions Elderly Environment Epigenetic Process Fathers Fatty acid glycerol esters Fetal Growth Fetal Malnutrition Fetus Finland Genes Genetic Genotype Growth Head circumference Health Health Benefit Healthcare Height Home environment Hormonal Hospitals Human Human Development Income Individual Infant Infection Investments Length Life Life Expectancy Life Style Link Longevity Longitudinal Studies Low Birth Weight Infant Malignant Neoplasms Malnutrition Measurement Measures Menarche Mental Health Metabolic Metabolism Molecular Mothers Newborn Infant Nutrient Occupations Pathologic Processes Persons Pharmaceutical Preparations Phenotype Physiological Placenta Plastics Pregnancy Prevention strategy Proteins Psyche structure Records Recurrence Relative (related person)Research Risk Sampling Schools Signal Transduction Socioeconomic Status Structure Uterus Variant Weight Woman base cohort critical period developmental plasticity fetus nutrition genome wide association study girls indexing insight men mortality mother nutrition next generation nutrition physical conditioning postnatal programs public health relevance resilience response socioeconomics stressor

项目摘要

DESCRIPTION (provided by applicant): Within any level of socio-economic status there is a wide variation in lifespan. Our hypothesis is that this variation is programmed during development. We propose that poor intrauterine nutrition and poor childhood living conditions initiate pathological processes and permanently change the body's structure and function in ways that make it vulnerable to stressors in postnatal life. Because intrauterine nutrition is determined by the mother's lifetime nutrition our findings will quantify how investment in the nutrition and growth of girls and young women will increase the lifespan of the next generation. The Helsinki Birth Cohort Study of 20,000 people is the only known data set in the world that includes maternal body size, birth size, infant and childhood growth and living conditions of people now at the end of their lives. The cohort includes detailed socioeconomic data recorded at each 5 yearly national census. We also propose that the ability to sustain physical and mental health in old age is programmed during development. We will explore the effects of intrauterine nutrition and childhood living conditions on resilience in old age; and we will examine whether there are periods of growth that are critical for this. This will inform preventive strategies that promote well being in early life and protect vulnerable elderly people. In subsequent studies, which are not the subject of this application, we will use the genome wide scan that has already been carried out to distinguish environmental and genetic effects on resilience in old age. Specific Aim 1: To determine how maternal nutrition and childhood living conditions predict all cause mortality, taking into account socio-economic conditions in later life. In two register-based studies of 7086 and 13,345 men and women, we will relate these early life influences to mortality from all causes and from cardiovascular and non-cardiovascular causes separately. Specific Aim 2: To determine how maternal nutrition and childhood living conditions predict changes in physical and mental health in later life, taking into account adult life-style, socio-economic conditions and illness. In a longitudinal study of a sub-sample of 1600 people we will relate these early life influences to changes in indices of physiological, mental and biochemical health. Specific Aim 3: To determine whether there are critical periods of growth between birth and age eleven years that predict all-cause mortality and changes in physical and mental health in later life. In a register- based study of 13,345 men and women, and in a longitudinal study in a sub-sample of 1600 people, we will examine how change in height and body mass index between different ages is related to mortality from cardiovascular and non-cardiovascular causes and to indices of physiological, mental and biochemical health. PUBLIC HEALTH RELEVANCE: We propose that the maternal and early postnatal environments establish vulnerability to chronic disease in old age, and determine elderly people's ability to sustain their health. An understanding of this may make it possible to identify elderly people who are at risk of physical or mental deterioration, and to prolong healthy life.

描述（由申请人提供）：在任何社会经济地位的任何级别内，寿命都有很大差异。我们的假设是，这种变化是在开发过程中编程的。我们建议，贫困的宫内营养和贫困的童年生活条件会引发病理过程，并以使其容易受到产后压力的方式永久改变身体的结构和功能。由于宫内营养是由母亲的终生营养决定的，我们的发现将量化在女孩和年轻女性的营养和成长中的投资将如何提高下一代的寿命。赫尔辛基（Helsinki）对20,000人的赫尔辛基出生队列研究是世界上唯一已知的数据集，其中包括产妇大小，出生率，婴儿和童年的成长以及现在生命即将结束的人们的生活状况。该队列包括每年5年的全国人口普查记录的详细社会经济数据。我们还建议在开发过程中编程了在老年内维持身心健康的能力。我们将探讨宫内营养和儿童生活条件对老年弹性的影响；我们将研究是否有重要的增长周期至关重要。这将为预防策略提供促进早期生活并保护脆弱的老年人的预防策略。在随后的研究不是本应用主题的过程中，我们将使用已经进行的基因组广泛的扫描来区分对老年弹性的环境和遗传影响。具体目的1：确定母亲的营养和儿童生活条件如何预测所有人的死亡率，考虑到以后的生活中的社会经济状况。在两项基于7086和1345名男女的基于登记册的研究中，我们将分别从各种原因以及心血管和非心血管造成的原因与死亡率联系起来。具体目标2：确定孕产妇的营养和儿童生活条件如何预测后来生活的身体和心理健康的变化，考虑到成人的生活方式，社会经济状况和疾病。在对1600人子样本的纵向研究中，我们将将这些早期生活的影响与生理，心理和生化健康指数的变化联系起来。特定目标3：确定在出生到11岁之间是否存在关键的生长，可以预测以后生活中全因死亡率以及身心健康的变化。在对13345名男性和女性的基于登记册的研究中，以及在1600人的纵向研究中，我们将研究不同年龄之间的身高和体重指数的变化与心血管和非心血管引起的死亡率以及生理，心理和精神和生物学健康的指数有关。公共卫生相关性：我们建议母亲和早期产后环境在老年内脆弱，并确定老年人维持健康的能力。对此的理解可能会使识别有身体或精神恶化风险并延长健康生活的老年人。