Defining the differential roles of Glutamatergic and GABAergic projections from the Lateral Preoptic Area to the Lateral Habenula in Reward, Aversion, and Drug-Seeking Behavior.
定义从外侧视前区到外侧缰核的谷氨酸能和 GABA 能投射在奖励、厌恶和药物寻求行为中的不同作用。
基本信息
- 批准号:10242872
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAnatomyArchitectureAversive StimulusAwardAxonBehavioralBrainCalciumCellsCocaineCocaine DependenceComplexCuesDataDendritesDrug AddictionDrug abuseElectron MicroscopyElectrophysiology (science)EnvironmentFemaleFiberFiber OpticsGABA ReceptorGenderGlutamate ReceptorGlutamatesGoalsGrantHabenulaHumanImageImmunoelectron MicroscopyIndividual DifferencesInterventionLabelLateralLeadLocationMeasuresMental DepressionMental disordersMentorsMentorshipModelingMoraleMusNeuronsOutcomePathway interactionsPatternPharmaceutical PreparationsPharmacotherapyPhasePhotometryPlayPreoptic AreasPresynaptic TerminalsProceduresProcessPublic HealthPublishingPunishmentResearchRewardsRoleRunningSelf AdministrationSick RoleSignal TransductionStimulusStructureSucroseSynapsesSyndromeTechniquesTestingTracerTrainingUnited StatesViralWorkaddictionanimal tissuebasal forebraincalcium indicatorcocaine self-administrationconditioned fearconditioned place preferencedensitydrug relapsedrug seeking behaviordual diagnosisexperimental studygamma-Aminobutyric Acidgender differencein vivoin vivo calcium imaginginsightinterestmalemotivated behaviornervous system disorderneuronal cell bodynovelpostsynapticpreferencepresynapticprogramsreceptorresponsereward processingtool
项目摘要
Project Summary/Abstract
Drug addiction is a complex neurological disorder which produces aberrant function in limbic circuits and
limbic-associated structures. One specific portion of the basal forebrain—the lateral preoptic area—serves as an
important relay between limbic structures and the lateral habenula, a region that has been implicated in
addiction and depression. Under the primary mentorship of Drs. Marisela Morales and Geoffrey Schoenbaum,
the present Pathway to Independence award will allow me to obtain training in electron microscopy and in vivo
calcium imaging in order to elucidate the role of the preopto-habenular projection in the processing of
rewarding and aversive stimuli, and eventually the role that this circuitry plays in cocaine addiction. In the
mentored phase of this grant, I will use a combination of viral tracers and immuno-electron microscopy in
order to determine the targets of the lateral preoptic area glutamatergic and GABAergic axons that establish
synapses on lateral habenula neurons and to determine how individual differences in postsynaptic receptors
contribute to individual differences in the processing of rewarding and aversive stimuli. Subsequently, fiber
photometry calcium imaging will be used in order to determine how the terminals of lateral preoptic
glutamatergic and GABAergic neurons in the lateral habenula process rewarding or aversive outcomes and
their associated cues. In the independent phase, I will combine these cutting-edge techniques with my prior
training in order to simultaneously record the axon terminals of lateral preoptic neurons in the lateral
habenula using fiber photometry and the responses of the postsynaptic cells in the lateral habenula using
single-unit electrophysiological recordings in order to establish a role for the preopto-habenular pathway in
cocaine self-administration, punishment-imposed abstinence, and cued reinstatement. In summary, the
research proposed in this Pathway to Independence Award will elucidate the ultrastructural architecture and
functional mechanisms of a novel circuit that participates in cocaine self-administration while simultaneously
providing me with the tools to establish an independent research program capable of producing high impact
studies that bridge anatomical data with cutting-edge techniques for examining circuit function.
项目总结/文摘
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Lateral preoptic area glutamate neurons relay nociceptive information to the ventral tegmental area.
- DOI:10.1016/j.celrep.2023.113029
- 发表时间:2023-09-26
- 期刊:
- 影响因子:8.8
- 作者:
- 通讯作者:
pMAT: An open-source software suite for the analysis of fiber photometry data.
- DOI:10.1016/j.pbb.2020.173093
- 发表时间:2021-03
- 期刊:
- 影响因子:0
- 作者:Bruno CA;O'Brien C;Bryant S;Mejaes JI;Estrin DJ;Pizzano C;Barker DJ
- 通讯作者:Barker DJ
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
David J Barker其他文献
David J Barker的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('David J Barker', 18)}}的其他基金
Defining the differential roles of Glutamatergic and GABAergic projections from the Lateral Preoptic Area to the Lateral Habenula in Reward, Aversion, and Drug-Seeking Behavior.
定义从外侧视前区到外侧缰核的谷氨酸能和 GABA 能投射在奖励、厌恶和药物寻求行为中的不同作用。
- 批准号:
9926602 - 财政年份:2019
- 资助金额:
$ 24.9万 - 项目类别:
Accumbens firing and ultrasonic vocalizations during cocaine self-administration
可卡因自我给药期间伏隔肌发射和超声波发声
- 批准号:
8450461 - 财政年份:2012
- 资助金额:
$ 24.9万 - 项目类别:
Accumbens firing and ultrasonic vocalizations during cocaine self-administration
可卡因自我给药期间伏隔肌发射和超声波发声
- 批准号:
8255958 - 财政年份:2012
- 资助金额:
$ 24.9万 - 项目类别:
The Developmental Origins of Disease and Deterioration in Old Age
老年疾病和恶化的发育起源
- 批准号:
8535311 - 财政年份:2010
- 资助金额:
$ 24.9万 - 项目类别:
The Developmental Origins of Disease and Deterioration in Old Age
老年疾病和恶化的发育起源
- 批准号:
7886374 - 财政年份:2010
- 资助金额:
$ 24.9万 - 项目类别:
The Developmental Origins of Disease and Deterioration in Old Age
老年疾病和恶化的发育起源
- 批准号:
8134876 - 财政年份:2010
- 资助金额:
$ 24.9万 - 项目类别:
相似海外基金
Linking Epidermis and Mesophyll Signalling. Anatomy and Impact in Photosynthesis.
连接表皮和叶肉信号传导。
- 批准号:
EP/Z000882/1 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Fellowship
Digging Deeper with AI: Canada-UK-US Partnership for Next-generation Plant Root Anatomy Segmentation
利用人工智能进行更深入的挖掘:加拿大、英国、美国合作开发下一代植物根部解剖分割
- 批准号:
BB/Y513908/1 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Social and ecological influences on brain anatomy
博士论文研究:社会和生态对大脑解剖学的影响
- 批准号:
2235348 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Standard Grant
Simultaneous development of direct-view and video laryngoscopes based on the anatomy and physiology of the newborn
根据新生儿解剖生理同步开发直视喉镜和视频喉镜
- 批准号:
23K11917 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Computational comparative anatomy: Translating between species in neuroscience
计算比较解剖学:神经科学中物种之间的翻译
- 批准号:
BB/X013227/1 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Research Grant
computational models and analysis of the retinal anatomy and potentially physiology
视网膜解剖学和潜在生理学的计算模型和分析
- 批准号:
2825967 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Studentship
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
OSA 极端表型的遗传学及相关上呼吸道解剖学
- 批准号:
10555809 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Development of a novel visualization, labeling, communication and tracking engine for human anatomy.
开发一种新颖的人体解剖学可视化、标签、通信和跟踪引擎。
- 批准号:
10761060 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Understanding the functional anatomy of nociceptive spinal output neurons
了解伤害性脊髓输出神经元的功能解剖结构
- 批准号:
10751126 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
The Anatomy of Online Reviews: Evidence from the Steam Store
在线评论剖析:来自 Steam 商店的证据
- 批准号:
2872725 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Studentship