Defining the differential roles of Glutamatergic and GABAergic projections from the Lateral Preoptic Area to the Lateral Habenula in Reward, Aversion, and Drug-Seeking Behavior.

定义从外侧视前区到外侧缰核的谷氨酸能和 GABA 能投射在奖励、厌恶和药物寻求行为中的不同作用。

基本信息

  • 批准号:
    10242872
  • 负责人:
  • 金额:
    $ 24.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-15 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Drug addiction is a complex neurological disorder which produces aberrant function in limbic circuits and limbic-associated structures. One specific portion of the basal forebrain—the lateral preoptic area—serves as an important relay between limbic structures and the lateral habenula, a region that has been implicated in addiction and depression. Under the primary mentorship of Drs. Marisela Morales and Geoffrey Schoenbaum, the present Pathway to Independence award will allow me to obtain training in electron microscopy and in vivo calcium imaging in order to elucidate the role of the preopto-habenular projection in the processing of rewarding and aversive stimuli, and eventually the role that this circuitry plays in cocaine addiction. In the mentored phase of this grant, I will use a combination of viral tracers and immuno-electron microscopy in order to determine the targets of the lateral preoptic area glutamatergic and GABAergic axons that establish synapses on lateral habenula neurons and to determine how individual differences in postsynaptic receptors contribute to individual differences in the processing of rewarding and aversive stimuli. Subsequently, fiber photometry calcium imaging will be used in order to determine how the terminals of lateral preoptic glutamatergic and GABAergic neurons in the lateral habenula process rewarding or aversive outcomes and their associated cues. In the independent phase, I will combine these cutting-edge techniques with my prior training in order to simultaneously record the axon terminals of lateral preoptic neurons in the lateral habenula using fiber photometry and the responses of the postsynaptic cells in the lateral habenula using single-unit electrophysiological recordings in order to establish a role for the preopto-habenular pathway in cocaine self-administration, punishment-imposed abstinence, and cued reinstatement. In summary, the research proposed in this Pathway to Independence Award will elucidate the ultrastructural architecture and functional mechanisms of a novel circuit that participates in cocaine self-administration while simultaneously providing me with the tools to establish an independent research program capable of producing high impact studies that bridge anatomical data with cutting-edge techniques for examining circuit function.
项目总结/文摘

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Lateral preoptic area glutamate neurons relay nociceptive information to the ventral tegmental area.
  • DOI:
    10.1016/j.celrep.2023.113029
  • 发表时间:
    2023-09-26
  • 期刊:
  • 影响因子:
    8.8
  • 作者:
  • 通讯作者:
pMAT: An open-source software suite for the analysis of fiber photometry data.
  • DOI:
    10.1016/j.pbb.2020.173093
  • 发表时间:
    2021-03
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Bruno CA;O'Brien C;Bryant S;Mejaes JI;Estrin DJ;Pizzano C;Barker DJ
  • 通讯作者:
    Barker DJ
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David J Barker其他文献

David J Barker的其他文献

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{{ truncateString('David J Barker', 18)}}的其他基金

Defining the differential roles of Glutamatergic and GABAergic projections from the Lateral Preoptic Area to the Lateral Habenula in Reward, Aversion, and Drug-Seeking Behavior.
定义从外侧视前区到外侧缰核的谷氨酸能和 GABA 能投射在奖励、厌恶和药物寻求行为中的不同作用。
  • 批准号:
    9926602
  • 财政年份:
    2019
  • 资助金额:
    $ 24.9万
  • 项目类别:
Accumbens firing and ultrasonic vocalizations during cocaine self-administration
可卡因自我给药期间伏隔肌发射和超声波发声
  • 批准号:
    8450461
  • 财政年份:
    2012
  • 资助金额:
    $ 24.9万
  • 项目类别:
Accumbens firing and ultrasonic vocalizations during cocaine self-administration
可卡因自我给药期间伏隔肌发射和超声波发声
  • 批准号:
    8255958
  • 财政年份:
    2012
  • 资助金额:
    $ 24.9万
  • 项目类别:
The Developmental Origins of Disease and Deterioration in Old Age
老年疾病和恶化的发育起源
  • 批准号:
    8535311
  • 财政年份:
    2010
  • 资助金额:
    $ 24.9万
  • 项目类别:
The Developmental Origins of Disease and Deterioration in Old Age
老年疾病和恶化的发育起源
  • 批准号:
    7886374
  • 财政年份:
    2010
  • 资助金额:
    $ 24.9万
  • 项目类别:
The Developmental Origins of Disease and Deterioration in Old Age
老年疾病和恶化的发育起源
  • 批准号:
    8134876
  • 财政年份:
    2010
  • 资助金额:
    $ 24.9万
  • 项目类别:

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