Real-time verification of proton dose delivery
质子剂量输送的实时验证
基本信息
- 批准号:8079480
- 负责人:
- 金额:$ 2.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-01 至 2011-12-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsAnatomyAreaAwardBindingBiologicalCalibrationCancer PatientCancerousCategoriesCell NucleusCharacteristicsClinicalDataDepositionDetectionDevelopmentDoseEffectivenessElectronicsElectronsElementsEnsureEvaluationExternal Beam Radiation TherapyFamily suidaeFatty acid glycerol estersFeedbackGamma RaysGoalsGrantHistocompatibility TestingHypoxiaImageIncidenceIndividualKidneyLeadLeftLegal patentLiverLungMapsMeasurementMeasuresMethodsModelingMonitorMuscleNatureNoiseNormal tissue morphologyNuclearOncologistOpticsOutcomeOxygenPaperPatientsPhysicsProceduresProcessProtonsPublishingQuality of lifeRadiationRadiation therapyReaction TimeResearchResolutionSheepSpectrum AnalysisStagingStudy modelsSystemTechniquesTimeTissue SampleTissuesUncertaintyWidthWorkX-Ray Computed Tomographyanaloganimal tissuebaseboneclinical applicationdensitydetectorhuman tissueimage reconstructionimaging modalityimprovedin vivoinnovationirradiationnovelproton beampublic health relevanceresponsetreatment planningtumor
项目摘要
DESCRIPTION (provided by applicant): During proton therapy treatment, protons interact with both the nucleus and bound electrons of atoms within patient tissue. Proton-nucleus interactions can leave behind an intact atomic nucleus in an excited energy state that quickly decays, frequently through emission of a characteristic gamma-ray, a phenomenon known as "prompt emission". This gamma emission occurs only where proton-nucleus interactions (and thus dose deposition) occur and the energy spectrum of the emission is dependent on the specific atomic composition of the irradiated tissue. We hypothesize that by properly measuring the prompt gamma-ray emission that occurs during proton dose delivery, the dose delivery and the composition of tissue irradiated can be verified. The long term goal of this research is to develop a clinically viable Prompt Gamma Imaging (PGI) system capable of measuring both the composition and density of tissues irradiated within the patient. The specific aims of this proposal are (1) to determine the response of gamma-ray detectors within a proton treatment vault and (2) to determine the inherent resolution of image reconstruction for the proposed PGI method. To achieve the stated aims, both measurements and Monte Carlo calculations will be made to determine the shielding levels and detector timing response required to isolate and measure prompt emission during proton beam delivery. Calculations of the prompt emission detection process from a Monte Carlo model will be used to determine the effects of the finite energy and spatial resolution of the gamma-ray detectors on the resolution of images reconstructed with the proposed PGI method. Based on the results of these studies, we will determine the overall feasibility of measuring the prompt gamma-ray spectra emitted during proton beam radiotherapy and for reconstructing images of the composition and density of tissues irradiated with the proposed PGI method. The significance of a method to image and track changes to the elemental composition and densities of tissues irradiated during proton therapy is multi-fold. First, such a method could allow for the direct measurement of changes to the stopping powers for irradiated tissues over the course of treatment. The stopping power values obtained from measurements would allow for more accurate calculation of proton beam range and dose delivery within the patient over the course of treatment, thus improving accuracy of the proton treatment delivery. Second, PGI would provide a direct method to evaluate changes in irradiated tissues, such as tumor hypoxia or the elemental composition of healthy tissues over the treatment course that could be correlated to tumor response and/or the onset of normal tissue complications.
PUBLIC HEALTH RELEVANCE: The proposed research aims to develop novel methods to measure and image the atomic composition of tissues irradiated during proton radiotherapy in-vivo, allowing us to study biological changes and response of these tissues. This would provide a means to measure and track changes to elemental composition in these tissues on a daily basis over the course of treatment. Such capabilities would allow for the monitoring of a patient's response to proton radiotherapy (via measured changes to tissue composition), thus providing a means for the oncologists to change and adapt treatment delivery for each patient individually based on their measured response.
描述(由申请人提供):在质子治疗过程中,质子与患者组织内原子的原子核和束缚电子相互作用。质子与原子核的相互作用可以留下一个处于激发能态的完整原子核,该原子核通常通过发射特征伽马射线而迅速衰变,这种现象称为“瞬发发射”。这种伽马发射仅发生在质子-核相互作用(从而发生剂量沉积)的地方,并且发射的能谱取决于受照射组织的特定原子组成。我们假设,通过适当测量质子剂量输送过程中发生的即时伽马射线发射,可以验证剂量输送和辐照组织的组成。本研究的长期目标是开发一种临床可行的快速伽马成像(PGI)系统,能够测量患者体内受照射组织的成分和密度。本提案的具体目的是(1)确定质子治疗拱顶内伽马射线探测器的响应,以及(2)确定所提出的PGI方法的图像重建的固有分辨率。为了实现所述目标,将进行测量和蒙特卡罗计算,以确定在质子束输送期间隔离和测量瞬发发射所需的屏蔽水平和探测器定时响应。从蒙特卡罗模型的即时发射检测过程的计算将被用来确定有限的能量和空间分辨率的伽马射线探测器上的图像重建与建议的PGI方法的分辨率的影响。基于这些研究的结果,我们将确定测量质子束放射治疗过程中发出的即时伽马射线光谱的整体可行性,并重建与建议的PGI方法照射的组织的组成和密度的图像。成像和跟踪质子治疗期间被照射的组织的元素组成和密度的变化的方法的重要性是多方面的。首先,这种方法可以允许在治疗过程中直接测量被照射组织的阻止能力的变化。从测量获得的停止功率值将允许在治疗过程中更准确地计算质子束范围和患者体内的剂量递送,从而提高质子治疗递送的准确性。第二,PGI将提供一种直接的方法来评估受照射组织的变化,例如肿瘤缺氧或治疗过程中健康组织的元素组成,这些变化可能与肿瘤反应和/或正常组织并发症的发生相关。
公共卫生相关性:拟议的研究旨在开发新的方法来测量和成像质子放射治疗期间照射的组织的原子组成,使我们能够研究这些组织的生物学变化和反应。这将提供一种在治疗过程中每天测量和跟踪这些组织中元素组成变化的方法。此类功能将允许监测患者对质子放射治疗的反应(通过测量组织成分的变化),从而为肿瘤学家提供一种根据测量的反应单独改变和调整每位患者的治疗方式的方法。
项目成果
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Jerimy C. Polf其他文献
Jerimy C. Polf的其他文献
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{{ truncateString('Jerimy C. Polf', 18)}}的其他基金
3-dimensional prompt gamma imaging for online proton beam dose verification
用于在线质子束剂量验证的 3 维瞬发伽马成像
- 批准号:
10635210 - 财政年份:2023
- 资助金额:
$ 2.45万 - 项目类别:
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