Biotechnology Training in Biomedical Sciences and Engineering

生物医学科学与工程生物技术培训

• 批准号: 8100453
• 负责人: Harold George Monbouquette
• 金额: $ 19.91万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8100453
• 关键词: Biotechnology; Engineering; Science; Training

DESCRIPTION (provided by applicant): The goal of the UCLA Biotechnology Training in Biomedical Science and Engineering (BTBSE) Program is to educate and to train the next generation of highly skilled scientists and engineers who will assume leadership roles in multidisciplinary biotechnology research. This goal is achieved through a cohesive 2-year training program entailing multidisciplinary research, a common curriculum composed of formal coursework in life science and engineering and of a cross-disciplinary laboratory rotation, and an industrial internship. The required coursework is comprised of a course in macromolecular synthesis and structure, a course on molecular biotechnology from an engineer's perspective, the "Biotechnology Forum" course, and a class in research ethics. Life science trainees must work in the research laboratory of an engineering mentor for at least three months; likewise the engineers spend time in the laboratory of their life science mentor. A biotechnology community is fostered principally through the monthly trainee lunch seminar series and the Annual Biotechnology Symposium, which brings together ~50 students, faculty and industry representatives and is currently in its fourth successful installment. Trainees who complete this program will be equipped to function productively in the multidisciplinary teams of bioengineers and life scientists prevalent in the industry. The interface between the life/health sciences and engineering is extraordinarily rich in its diversity, and this biotechnology program focuses broadly on molecular and cellular research. Faculty participants in the proposed BTBSE Program all mentor PhD students who conduct research focused at the molecular and cellular level, and most have established cross-disciplinary collaborations. The faculty research activities cover a broad spectrum of basic biomedical research related to biotechnology including, enzyme biocatalysis, thermostable enzymes, metabolic engineering, DNA microarray technology, nitric oxide metabolism, molecular basis of neurodegenerative disease, biosensors, tissue engineering, anaerobe microbiology, vaults (protein nanocapsules), nanobiotechnology, bioinformatics, genomics, proteomics, protein molecular evolution, and incorporation of unnatural amino acids in recombinant proteins. Such an array of research activities conducted by collaborating researchers provides an exciting menu of multidisciplinary research opportunities to trainees. Faculty participants in the proposed training program have had the opportunity to recruit from a pool of 127 eligible PhD students (including 13 underrepresented minority students) this academic year. The Director and faculty mentors are very active and successful in underrepresented minority student development and recruitment, especially from the very diverse, populous greater Los Angeles area. It is planned to grow the program over the next several years to a trainee graduation rate of 6/year (12 in training/yr). In sum, UCLA provides the talented multidisciplinary faculty, bright and diverse students, resources for research, courses, and opportunities to interact with industry that are necessary to mount a successful biotechnology training program. PUBLIC HEALTH RELEVANCE: This program will educate and train outstanding PhD students in the application of the principles of life science and engineering to health related problems. After earning their degrees, most former trainees are expected to assume leadership roles in the biotechnology industry, which is focused on commercialization of pharmaceuticals and other health-related products.

描述（由申请人提供）：加州大学洛杉矶分校生物医学科学与工程生物技术培训（BTBSE）项目的目标是教育和培训下一代高技能的科学家和工程师，他们将在多学科生物技术研究中担任领导角色。这一目标的实现是通过一个紧密结合的2年培训计划，包括多学科研究、由生命科学和工程的正式课程、跨学科实验室轮转和工业实习组成的共同课程。必修课程包括大分子合成与结构课程、工程师视角的分子生物技术课程、“生物技术论坛”课程和研究伦理课程。生命科学培训生必须在工程导师的研究实验室工作至少三个月；同样地，工程师们花时间在他们的生命科学导师的实验室里。主要通过每月的培训生午餐系列研讨会和年度生物技术研讨会来培养生物技术社区，该研讨会汇集了约50名学生，教师和行业代表，目前已成功举办了第四届。完成本课程的学员将具备在行业中普遍存在的生物工程师和生命科学家的多学科团队中高效工作的能力。生命/健康科学和工程学之间的接口在其多样性方面非常丰富，这个生物技术项目广泛地关注分子和细胞研究。拟议的BTBSE计划的教师参与者都指导博士生进行专注于分子和细胞水平的研究，并且大多数已经建立了跨学科合作。该学院的研究活动涵盖了与生物技术相关的广泛的基础生物医学研究，包括酶生物催化、热稳定酶、代谢工程、DNA微阵列技术、一氧化氮代谢、神经退行性疾病的分子基础、生物传感器、组织工程、厌氧菌微生物学、vaults（蛋白质纳米胶囊）、纳米生物技术、生物信息学、基因组学、蛋白质组学、蛋白质分子进化、在重组蛋白中掺入非天然氨基酸。由合作研究人员进行的一系列研究活动为受训者提供了令人兴奋的多学科研究机会。本学年，参加拟议培训计划的教师有机会从127名符合条件的博士生（包括13名未被充分代表的少数民族学生）中招聘。主任和教师导师在少数族裔学生的发展和招聘方面非常积极和成功，特别是来自非常多样化、人口稠密的大洛杉矶地区。计划在未来几年内将该项目发展到6名学员/年（12名学员/年）的毕业率。总而言之，加州大学洛杉矶分校提供了多学科的优秀教师、聪明而多样化的学生、研究资源、课程以及与行业互动的机会，这些都是成功开展生物技术培训计划所必需的。