USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORT

描述（由申请人提供）：南加州大学/诺里斯综合癌症中心成立于1971年，自1973年以来一直得到癌症中心核心支持基金的支持。它已发展成为癌症研究、治疗、预防和教育的主要区域和国家资源。中心设施的建设和发展得到了NCI、大学和肯尼斯·莫里斯小癌症医院的支持，该医院是癌症中心的一个组成部分。该中心在1996年进行了一次大规模扩建，增加了诺曼塔，目前正在建设第三个设施，Harlyne Morris转化研究塔。该中心的191名成员被组织成5个主题和5个转化研究项目，包括一个发育治疗学的“桥梁”项目。各专题项目由分子遗传学、表观遗传学与调控、肿瘤微环境、癌症流行病学和癌症控制研究领域的资深研究员主持。这些转化项目为我们的多学科研究工作提供了重点，包括发育治疗、泌尿生殖系统癌症、胃肠道癌症、女性癌症以及血液学和病毒相关恶性肿瘤。本申请是为了：1)中心高级领导的部分工资支持，他们负责规划和监督我们的研究工作；2)支持项目规划和评估，使中心保持在癌症研究的前沿；3)支持中心的行政基础设施建设；4)部分支持中心的13个共享资源，以促进我们同行评议研究的开展；5)为发展基金提供支持，帮助我们在我们的扩张目标领域招募新的研究人员。来自癌症中心核心支持基金的持续资助将使我们能够在基础研究和基于人群的研究方面发挥优势，并将我们的基础专业知识转化为强大的、同行评审的资助研究项目，重点研究这个国家的主要后果癌症。癌症中心成员目前持有总计9100万美元的直接费用，其中4000万美元来自NCI（不包括CCSG）。

DESCRIPTION (provided by applicant): The USC/Norris Comprehensive Cancer Center at the University of Southern California was founded in 1971 and has been continuously supported by a Cancer Center Core Support Grant since 1973. It has developed into a major regional and national resource for cancer research, treatment, prevention and education. Center facilities have been built and developed with support from the NCI, the University and the Kenneth Morris Jr. Cancer Hospital, which is an integral part of the Cancer Center. The Center underwent a major expansion with the addition of the Norman Topping Tower in 1996 and is currently building a third facility, the Harlyne Morris Translational Research Tower. The Center's 191 members are organized into five thematic and five translational research programs, including a "bridge" program in developmental therapeutics. The thematic programs are headed by senior investigators in the fields of molecular genetics, epigenetics and regulation, tumor microenvironment, cancer epidemiology and cancer control research. The translational programs, which provide focus to our multidisciplinary research efforts, are in developmental therapeutics, genitourinary cancers, gastrointestinal cancers, women's cancers and hematologic and viral-associated malignancies. This application is for: 1) partial salary support for the Center's senior leadership, who are responsible for planning and overseeing our research efforts; 2) support for program planning and evaluation to keep the Center at the forefront of cancer research; 3) support for the administrative infrastructure of the Center; 4) partial support for the Center's 13 shared resources which facilitate the conduct of our peer-reviewed research; and 5) support for developmental funds to help us recruit new investigators in areas we have targeted for expansion. Continued funding from the Cancer Center Core Support Grant will allow us to build on our strengths in basic and population-based research and to translate our underlying expertise into strong, peer-reviewed funded research programs focused on cancers of major consequence in this country. Cancer Center members currently hold grants totaling $91 million in direct costs, with $40 million of that coming from NCI (all exclusive of the CCSG).