Vascular Effects on Normal Neural and Cognitive Aging

血管对正常神经和认知衰老的影响

• 批准号: 8149838
• 负责人: Karen M Rodrigue
• 金额: $ 8.95万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8149838
• 关键词: Adult; Adverse effects; Affect; Age; Aging; Amyloid; Amyloid deposition; Automobile Driving; Award; Blood Vessels; Brain; Categories; Cerebrum; Chronic; Cognition; Cognitive; Cognitive aging; Control Groups; Core-Binding Factor; Data; Dementia; Deterioration; Development; Doctor of Philosophy; Early Diagnosis; Elderly; Ensure; Essential Hypertension; Exhibits; Functional Magnetic Resonance Imaging; Goals; Health; Hypertension; Impaired cognition; Impairment; Individual; Individual Differences; Knowledge; Lobe; Longevity; Maintenance; Measures; Medial; Memory; Mentors; Metabolic; Methodology; Mission; Modeling; National Institute on Aging; Nerve Degeneration; Neurocognitive; Nutrient; Oxygen; Participant; Pathway interactions; Pattern; Performance; Perfusion; Phase; Positioning Attribute; Positron-Emission Tomography; Prevalence; Prevention; Process; Psyche structure; Publishing; Recruitment Activity; Regional Perfusion; Research; Research Proposals; Risk; Risk Factors; Role; Sampling; Shapes; Short-Term Memory; Specificity; Structure; Testing; Training; Vascular System; Vascular blood supply; age related; aged; aging population; amyloid precursor protein processing; base; cerebrovascular; cognitive neuroscience; expectation; healthy aging; long term memory; middle age; normal aging; normotensive; novel; pathological aging; processing speed; programs; public health relevance; relating to nervous system; skills

DESCRIPTION (provided by applicant): The objectives of this Pathway to Independence Award for Karen M. Rodrigue, Ph.D., are to deepen the candidate's expertise in the field of cognitive neuroscience to enable her to investigate novel questions regarding the role of vascular risk in brain and cognitive aging. The central aim of this project is to examine a vascular hypothesis of aging which investigates the role of general vascular risk factors, such as hypertension, and specific cerebrovascular mechanisms such as hypoperfusion, in shaping the course of neural and cognitive aging within a normal aging model. The proposed K99 phase of research focuses on this aim by testing the hypothesis that age-related alteration in regional brain perfusion predicts decline in the cognitive performance of healthy middle-aged and older adults. The mentored phase also examines the modifying effects of hypertension on neural activity in an fMRI paradigm, testing the hypothesis that differences in vascular health can explain age-related dedifferentiation of brain function. A cross-sectional individual differences approach with a lifespan sample will be used to test hypotheses in the K99 phase. The R00 phase extends the study of the impact of vascular health on neural and cognitive decline by examining vascular predictors of ¿-amyloid deposition in normal aging. The objectives of this research proposal are in accord with the mission of the National Institute on Aging. Understanding the contributions of vascular health to successful, as well as pathological aging is fundamentally important given both the prevalence of vascular risk in the aging population, and its amenability to prevention and treatment. The research skills and knowledge gained by the applicant during the completion of this project (e.g., training in fMRI, perfusion and PET imaging) along with the proposed coursework and professional development activities outlined in the training plan, will enable her to successfully transition to an independent position as a cognitive neuroscientist. PUBLIC HEALTH RELEVANCE: The present proposal examines a vascular hypothesis of aging which investigates the role of general vascular risk factors, such as hypertension, and specific cerebrovascular mechanisms such as hypoperfusion, in shaping the course of neural and cognitive aging within a normal aging model. Understanding the contributions of vascular health to successful, as well as pathological aging is fundamentally important given both the prevalence of vascular risk in the aging population, and its amenability to prevention and treatment.

描述（由申请人提供）：这个路径的目标，以独立奖凯伦M。Rodrigue博士，旨在加深候选人在认知神经科学领域的专业知识，使她能够研究有关血管风险在大脑和认知衰老中的作用的新问题。该项目的主要目的是研究血管老化假说，该假说调查了一般血管危险因素（如高血压）和特定脑血管机制（如灌注不足）在正常老化模型中塑造神经和认知老化过程中的作用。拟议的K99研究阶段的重点是通过测试以下假设来实现这一目标：与年龄相关的局部脑灌注变化预测健康中年人和老年人认知能力的下降。指导阶段还检查了高血压对功能磁共振成像范例中神经活动的修饰作用，测试了血管健康差异可以解释与年龄相关的脑功能去分化的假设。将使用具有寿命样本的横截面个体差异方法来检验K99阶段的假设。R00阶段通过检查正常衰老中淀粉样蛋白沉积的血管预测因子，扩展了血管健康对神经和认知衰退影响的研究。这项研究提案的目标与国家老龄问题研究所的使命是雅阁的。了解血管健康的贡献，成功的，以及病理老化是根本重要的，因为血管风险的流行在老龄化人口，其顺从性的预防和治疗。申请人在完成本项目期间获得的研究技能和知识（例如，在功能磁共振成像，灌注和PET成像培训）沿着拟议的课程和培训计划中概述的专业发展活动，将使她能够成功地过渡到一个独立的位置，作为一个认知神经科学家。 公共卫生相关性：本提案探讨了血管老化假说，调查的作用，一般血管危险因素，如高血压，和特定的脑血管机制，如低灌注，在塑造过程中的神经和认知老化的正常老化模型。了解血管健康的贡献，成功的，以及病理老化是根本重要的，因为血管风险的流行在老龄化人口，其顺从性的预防和治疗。

项目成果

Contributions of White Matter Connectivity and BOLD Modulation to Cognitive Aging: A Lifespan Structure-Function Association Study.

白质连接和 BOLD 调节对认知衰老的贡献：寿命结构-功能关联研究。

• DOI: 10.1093/cercor/bhz193
• 发表时间: 2020
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Webb,ChristinaE;Rodrigue,KarenM;Hoagey,DavidA;Foster,ChrisM;Kennedy,KristenM
• 通讯作者: Kennedy,KristenM

Beta-amyloid burden predicts poorer mnemonic discrimination in cognitively normal older adults.

• DOI: 10.1016/j.neuroimage.2020.117199
• 发表时间: 2020-11-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Webb CE;Foster CM;Horn MM;Kennedy KM;Rodrigue KM
• 通讯作者: Rodrigue KM