Advancing Physiological Signal Analysis for Mind-Body Research

描述（由申请人提供）：这个职业中期发展奖将为奥肯博士提供保护时间，以指导和提高他在生理信号采集和分析方面的能力。虽然他已经是一个成功的导师，他的学员成为成功的nih资助的院士证明了这一点，但他的时间已经并且将进一步受到他所指导的T32缺乏任何工资支持的限制。这个成功的T32目前有5名博士后和1名博士预科生。这位博士前候选人是T32上的第一位，她已经宣布奥肯博士是她行为神经科学博士论文的主要导师。除了增加当前的导师角色，K24将允许奥肯博士为他所指导的T32开发正式课程，为非cam临床研究和基础科学学员提供cam相关讲座，并为OHSU副院长正在开发的导师和职业发展计划分配时间。除了足够的资金来更好地指导他人之外，奥肯博士还将把这笔职业发展奖金的很大一部分用于提高他的实验室的信号分析和采集能力，包括增强使用与个人数字助理接口的24小时录音设备。这一开发将利用Mikel Aickin博士、Deniz Erdgomus博士和MSEE的Roger Ellingson的技术支持。这些系统将提供给那些在T32和其他对这些技术感兴趣的初级教师。一些职业发展基金将允许奥肯博士在波特兰州立大学攻读研究生水平的系统科学课程。分析技术将有助于开发：冥想干预的坚持和质量的生理测量；基于信息理论的电极间脑电图相关性测量，可能比其他领域已经使用的参数同步测量更有效；以及对24小时心率变异性的应激敏感测量。与24小时录音设备相连的个人数字助理允许频繁地、基于经验的抽样，对与身心相关的自评措施进行抽样，比如在实验室之外受试者通常的环境中感知到的压力和正念。这些测量将与使用系统科学方法的生理测量相关。

DESCRIPTION (provided by applicant): This mid-career development award will provide protected time for Dr. Oken to mentor and to advance his capability in physiological signal acquisition and analysis. While already a successful mentor, as evidenced by his mentees becoming successful NIH-funded academicians, his time has been and will be further limited by the lack of any salary support for the T32 he directs. This successful T32 currently has 5 post-doctoral and one pre-doctoral candidate. The pre-doctoral candidate is the first on the T32 and she has declared Dr Oken to be her primary mentor for her Behavioral Neuroscience PhD thesis. In addition to increasing current mentorship roles, the K24 will allow Dr. Oken to develop a formal curricula for the T32 he directs, give CAM-related lectures to non-CAM clinical research and basic science trainees, and to allocate time to the mentorship and career development program that the OHSU associate dean is developing. Besides sufficient funding to better mentor others, Dr. Oken will also spend a significant portion of this career development award advancing his lab's capability for signal analysis and acquisition including the enhanced use of a 24-hour recording device that is interfaced with a personal digital assistant. This development will utilize the technical support of Mikel Aickin, PhD, Deniz Erdgomus, PhD, and Roger Ellingson, MSEE. These systems will be available to those on the T32 and other junior faculty interested in these techniques. Some of the career development funds will allow Dr. Oken to take graduate level Systems Science courses at Portland State University. The analysis techniques will aid development of: a physiologic measure of adherence to and quality of meditation interventions; a measure of interelectrode EEG correlation based on information theory that is likely more valid than parametric synchrony measures already used by others in the field; and a stress- sensitive measure of 24-hour heart rate variability. The personal digital assistant interfaced to the 24-hour recording device allows for frequent, experience-based sampling of self-rated measures relevant to mind-body such as perceived stress and mindfulness outside the laboratory in the subject's usual environment. These measurements will be related to the physiological measurements using systems science approaches. PUBLIC HEALTH RELEVANCE: The general goal of this application is to promote Dr. Oken's ability to better mentor clinical complementary medicine researchers and to advance the field of mind-body research. This will be done by allowing Dr. Oken to decrease some of his administrative and clinical responsibilities and by developing new physiologic measures that can be used in mind-body research, including measures of stress, adherence to interventions, and positive effects on the brain. From a practical perspective this application will lead to more qualified young CAM clinical researchers and to improved clinical trials of mind-body medicine. Improved understanding of the benefits of mind-body medicine and possibly even improving mind-body techniques themselves has broad health implications to almost all medical care and health promotion.