Behavioral Interventions and Long Term Outcomes in Juvenile Fibromyalgia Syndrome

青少年纤维肌痛综合征的行为干预和长期结果

• 批准号: 8126238
• 负责人: Susmita Kashikar-Zuck
• 金额: $ 11.15万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8126238
• 关键词: Adolescence; Adolescent; Award; Behavior Therapy; Child; Childhood; Chronic; Clinical; Clinical Investigator; Clinical Research; Clinical Treatment; Clinical Trials; Cognitive Therapy; Data; Evidence based treatment; Faculty; Fibromyalgia; Funding; Future; Goals; Grant; Headache; Human; Institution; Instruction; Intervention; Longitudinal Studies; Manuscripts; Mentors; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Outcome; Outcomes Research; Pain; Pain Research; Patients; Persistent pain; Postdoctoral Fellow; Primary Fibromyalgias; Public Health; Randomized Clinical Trials; Research; Research Methodology; Research Personnel; Research Proposals; Scientist; Site; Sleep; Training; Translational Research; Writing; chronic pain; data management; effective therapy; efficacy testing; meetings; next generation; outcome forecast; patient oriented research; post-doctoral training; programs; prospective; psychosocial; research study

DESCRIPTION (provided by applicant): The Specific Aims of this Midcareer Investigator Award application are to 1) successfully implement an ongoing randomized clinical trial in juvenile fibromyalgia 2) perform a prospective longitudinal study to determine long term prognosis of pediatric patients with juvenile fibromyalgia, and 3) use the candidate's ongoing and planned studies in the Pediatric Pain Research Program to train post-doctoral fellows and junior faculty in pediatric pain research. The Candidate's programmatic line of research focuses on physical and psychosocial functioning of children and adolescents with chronic pain, with an emphasis on juvenile fibromyalgia syndrome - a very poorly understood chronic pain condition for which there is no evidence- based treatment. The Research Plan includes two projects: a NIAMS funded multi-site randomized clinical trial (ROl) to test the efficacy of cognitive behavioral treatment for children and adolescents with juvenile fibromyalgia, and a longitudinal study of outcomes in juvenile fibromyalgia. The candidate's future plans are to use findings from current projects to develop the most effective treatments for juvenile fibromyalgia and other pediatric pain conditions. The Mentoring Plan is to train future clinical investigators in the field of clinical interventions and outcomes research in pediatric chronic pain. The candidate's plan consists of 1) individualized mentoring of postdoctoral fellows supported by two currently funded clinical trials (Treatment of Juvenile Fibromyalgia, and Chronic Pediatric Headaches), the proposed longitudinal study in juvenile fibromyalgia, and other ongoing clinical and translational research studies in pediatric pain 2) mentoring of fellows to develop their own independent research proposals and 3) participation of fellows in established didactic programs on manuscript and grant writing, clinical research methodology and responsible conduct of human research. Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research, presence of an award winning chronic pain program, support from the Divisional Data Core for methodological and data management issues, and a commitment of the institution to "change the outcomes" for pediatric patients. RELEVANCE (See Instructions): This study meets the public health goal of better understanding and treating a poorly understood chronic pain condition of childhood (juvenile fibromyalgia) along with the goal of training the next generation of clinician-scientists in clinical and translational research in pediatric pain.

描述（由申请人提供）：此中期职业研究者奖申请的具体目标是 1) 成功实施一项正在进行的青少年纤维肌痛随机临床试验 2) 进行前瞻性纵向研究以确定青少年纤维肌痛儿科患者的长期预后，以及 3) 利用候选人在儿科疼痛研究计划中正在进行和计划的研究来培训博士后研究员和初级研究员 儿科疼痛研究教师。该候选人的计划研究重点是患有慢性疼痛的儿童和青少年的身体和心理社会功能，重点是青少年纤维肌痛综合征——一种人们知之甚少的慢性疼痛疾病，目前还没有基于证据的治疗方法。该研究计划包括两个项目：一项由 NIAMS 资助的多中心随机临床试验 (ROl)，以测试认知行为治疗对患有青少年纤维肌痛的儿童和青少年的疗效，以及一项针对青少年纤维肌痛结果的纵向研究。该候选人未来的计划是利用当前项目的发现来开发针对青少年纤维肌痛和其他儿科疼痛病症的最有效的治疗方法。指导计划旨在培训儿科慢性疼痛临床干预和结果研究领域的未来临床研究人员。候选人的计划包括 1) 对博士后研究员进行个性化指导，由两项目前资助的临床试验（青少年纤维肌痛的治疗和慢性小儿头痛）、拟议的青少年纤维肌痛纵向研究以及其他正在进行的儿科疼痛临床和转化研究提供支持 2) 指导研究员制定自己的独立研究提案，以及 3) 研究员的参与 参与关于手稿和拨款写作、临床研究方法和负责任的人类研究行为的既定教学计划。辛辛那提儿童医院为该奖项提供了理想的环境，因为机构对以患者为导向的研究提供了强有力的支持，拥有屡获殊荣的慢性疼痛项目，部门数据核心对方法和数据管理问题的支持，以及该机构致力于“改变儿科患者的结果”的承诺。相关性（参见说明）：本研究符合公共卫生目标，即更好地了解和治疗人们知之甚少的儿童慢性疼痛（青少年纤维肌痛），以及培训下一代临床医生科学家进行儿科疼痛的临床和转化研究。