Behavioral Interventions and Long Term Outcomes in Juvenile Fibromyalgia Syndrome

描述（申请人提供）：这项中期研究者奖申请的具体目的是：1）成功实施一项正在进行的青少年纤维肌痛随机临床试验; 2）进行一项前瞻性纵向研究，以确定青少年纤维肌痛儿科患者的长期预后，和3）利用候选人正在进行的和计划在儿科疼痛研究计划的研究，以培训博士后研究员和初级教师在儿科疼痛研究。候选人的研究计划侧重于慢性疼痛儿童和青少年的身体和心理功能，重点是青少年纤维肌痛综合征-一种非常不了解的慢性疼痛状况，没有循证治疗。该研究计划包括两个项目：NIAMS资助的多中心随机临床试验（ROl），以测试青少年纤维肌痛儿童和青少年认知行为治疗的疗效，以及青少年纤维肌痛结局的纵向研究。候选人的未来计划是利用当前项目的发现来开发青少年纤维肌痛和其他儿科疼痛疾病的最有效治疗方法。指导计划旨在培训未来儿科慢性疼痛临床干预和结局研究领域的临床研究者。候选人的计划包括1）由两个目前资助的临床试验支持的博士后研究员的个性化指导（青少年纤维肌痛和慢性儿童头痛的治疗），青少年纤维肌痛的拟议纵向研究，以及其他正在进行的儿科疼痛临床和转化研究2）指导研究员制定自己的独立研究计划，以及3）研究员参与有关手稿和赠款写作、临床研究方法和负责任地进行人类研究的既定教学计划。辛辛那提儿童医院为这一奖项提供了理想的环境，因为它对以患者为导向的研究提供了强大的机构支持，有一个屡获殊荣的慢性疼痛项目，来自分区数据核心的方法和数据管理问题的支持，以及该机构对儿科患者“改变结果”的承诺。相关性（见说明）：本研究符合公共卫生目标，即更好地了解和治疗儿童期慢性疼痛（青少年纤维肌痛），沿着培训下一代临床医生-科学家进行儿科疼痛临床和转化研究的目标。

DESCRIPTION (provided by applicant): The Specific Aims of this Midcareer Investigator Award application are to 1) successfully implement an ongoing randomized clinical trial in juvenile fibromyalgia 2) perform a prospective longitudinal study to determine long term prognosis of pediatric patients with juvenile fibromyalgia, and 3) use the candidate's ongoing and planned studies in the Pediatric Pain Research Program to train post-doctoral fellows and junior faculty in pediatric pain research. The Candidate's programmatic line of research focuses on physical and psychosocial functioning of children and adolescents with chronic pain, with an emphasis on juvenile fibromyalgia syndrome - a very poorly understood chronic pain condition for which there is no evidence- based treatment. The Research Plan includes two projects: a NIAMS funded multi-site randomized clinical trial (ROl) to test the efficacy of cognitive behavioral treatment for children and adolescents with juvenile fibromyalgia, and a longitudinal study of outcomes in juvenile fibromyalgia. The candidate's future plans are to use findings from current projects to develop the most effective treatments for juvenile fibromyalgia and other pediatric pain conditions. The Mentoring Plan is to train future clinical investigators in the field of clinical interventions and outcomes research in pediatric chronic pain. The candidate's plan consists of 1) individualized mentoring of postdoctoral fellows supported by two currently funded clinical trials (Treatment of Juvenile Fibromyalgia, and Chronic Pediatric Headaches), the proposed longitudinal study in juvenile fibromyalgia, and other ongoing clinical and translational research studies in pediatric pain 2) mentoring of fellows to develop their own independent research proposals and 3) participation of fellows in established didactic programs on manuscript and grant writing, clinical research methodology and responsible conduct of human research. Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research, presence of an award winning chronic pain program, support from the Divisional Data Core for methodological and data management issues, and a commitment of the institution to "change the outcomes" for pediatric patients. RELEVANCE (See Instructions): This study meets the public health goal of better understanding and treating a poorly understood chronic pain condition of childhood (juvenile fibromyalgia) along with the goal of training the next generation of clinician-scientists in clinical and translational research in pediatric pain.