Academic Career Award in Adolescent Alcohol Abuse

描述（由申请人提供）：本申请是根据PA-00-070学术生涯奖重新提交给NIAAA的。候选人是约翰·r·奈特医学博士，波士顿儿童医院青少年药物滥用研究中心主任，哈佛医学院儿科学助理教授。他是青少年药物滥用初级保健办公室管理方面的一位新兴专家，并就这一主题发表了原创科学文章、教育课程、临床评论和书籍章节。奈特博士在医学教育领域取得了相当大的成功，但在酒精治疗研究领域是较新的。他曾担任多项关于青少年酒精使用的医疗办公室管理研究的PI；包括一个NIAAA资助的项目，旨在验证在医疗办公室环境中使用的新的简短筛选试验。奈特博士还对青少年进行了一项简短干预的试点测试。在K07奖励期间，奈特博士将在酒精治疗研究方面开发新的知识、技能和经验。他将对一种新的简短干预方法进行随机对照试验，该方法先前在急诊科环境中被证明是有效的。他的长期职业目标是开发、测试和传播一套完整的管理青少年药物滥用的医疗实践指南。在K07奖的支持下，他还将在哈佛大学公共卫生学院完成研究设计和生物统计分析课程，这将确保他未来作为一名研究人员和导师的成功。Knight博士在波士顿儿童医院（Children’s Hospital Boston）的普通儿科和青少年/青年医学部门以及精神病学部门担任联合任命，这使他处于培训和指导新研究人员的理想位置。他指导的一名年轻教员最近因一项关于青少年药物测试的研究获得了她的第一笔拨款。他的另一位前导师最近完成了一项关于父母酒精筛查的试点研究，奈特博士获得了NIAAA在“代表性不足的少数群体研究补编”（PA-99-104）下的奖励。Knight博士还被选为Project Mainstream的导师，这是一个由卫生资源和服务管理局资助的药物滥用教育的国家教师发展项目。波士顿儿童医院提供了一个理想的研究和培训环境。它是美国最大的儿科医疗中心，儿童医院最近建立了一个临床研究项目，其任务是培训和协助新的临床研究者。奈特博士在教学和培训方面的背景，以及与国家组织建立的关系，将有助于确保他的研究成果得到尽可能广泛的传播。

DESCRIPTION (provided by applicant): This application is re-submitted to NIAAA in response to PA-00-070, Academic Career Award. The candidate is John R. Knight MD, the Director of the Center for Adolescent Substance Abuse Research at Children's Hospital Boston, and an Assistant Professor of Pediatrics at Harvard Medical School (HMS). He is an emerging expert on primary care office management of adolescent substance abuse, and has published original scientific articles, educational curricula, clinical reviews, and book chapters on this topic. Dr. Knight has achieved considerable success in the field of medical education, but is newer to the field of alcohol treatment research. He has served as PI of several studies on medical office management of adolescent alcohol use; including one NIAAA funded project aimed at validation of a new brief screening test for use in medical office settings. Dr. Knight has also conducted pilot testing of a brief intervention for adolescents. During the K07 award period, Dr. Knight will develop new knowledge, skills, and experience in alcohol treatment research. He will conduct a randomized controlled trial of a new brief intervention approach, previously proven effective in the emergency department setting. His long-term career goal is to develop, test, and disseminate a complete set of medical practice guidelines for management of adolescent substance abuse. With support from the K07 award, he will also complete courses in research study design and biostatistical analysis at the Harvard School of Public Health, which will ensure his future success as a researcher and mentor. Dr. Knight has joint appointments in the Divisions of General Pediatrics and Adolescent/Young Adult Medicine and the Department of Psychiatry at Children's Hospital Boston, placing him in an ideal position to train and mentor new investigators. One junior faculty member he mentors recently received her first grant award for a study of adolescent drug testing. Another former fellow he mentors recently completed a pilot study of alcohol screening of parents, through an award Dr. Knight obtained from NIAAA under Research Supplement for Underrepresented Minorities (PA-99-104). Dr. Knight was also selected as a mentor for Project Mainstream, a national faculty development project in substance abuse education funded by the Health Resources and Services Administration. Children's Hospital Boston presents an ideal research and training environment. It is the largest pediatric medical center in the U.S. Children's recently established a Clinical Research Program, whose mission is to train and assist new clinical investigators. Dr. Knight's background in teaching and training, and established relationships with national organizations, will help ensure the widest possible dissemination of his research findings.