Imaging Pain and Analgesia: Mentoring in Basic and Applied Research

影像疼痛和镇痛：基础和应用研究的指导

• 批准号: 8110513
• 负责人: DAVID BORSOOK
• 金额: $ 4.31万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8110513
• 关键词: Ablation; Absence of pain sensation; Acute; Adult; Affect; Analgesics; Applied Research; Area; Back; Basic Science; Boston; Brain; CNS processing; Capsaicin; Cell Nucleus; Cephalic; Child; Childhood; Clinical; Clinical Data; Clinical Trials; Cognitive Science; Comb animal structure; Commit; Complex Regional Pain Syndromes; Coughing; Data; Development; Disease; Drug Evaluation; Dura Mater; Emotional; Enrollment; Environment; Esthesia; Evolution; Face; Foundations; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Future; Hair; Hand; Health; Hour; Human; Hypersensitivity; Image; Institutes; Intracranial Hypertension; Ipsilateral; K-Series Research Career Programs; Limb structure; Location; Massachusetts; Measures; Mechanics; Medial; Mediating; Medical center; Mentors; Migraine; Modeling; National Institute of Neurological Disorders and Stroke; Nature; Neuronal Plasticity; Neurons; Operating Rooms; Pain; Pain-Free; Painless; Pathway interactions; Patients; Pattern; Pediatric Hospitals; Pontine structure; Population; Positioning Attribute; Postoperative Period; Primary Hyperalgesias; Process; Recovery; Reporting; Research; Research Design; Research Personnel; Scanning; Scientist; Secondary Hyperalgesias; Sensory; Sensory Process; Signal Transduction; Site; Skin; Sneezing; Solid; Somatosensory Cortex; Stimulus; Structure of trigeminal ganglion; Structure of trigeminal nerve spinal tract nucleus; System; Technology; Testing; Thalamic structure; Therapeutic Intervention; Thumb structure; Time; Touch sensation; Training; Trigeminal Neuralgia; Trigeminal Nuclei; Trigeminal System; Trigeminal nerve structure; Universities; allodynia; base; career; career development; central sensitization; cutaneous allodynia; diffuse optical tomography; drug development; frontal lobe; gang; healthy volunteer; hemodynamics; human disease; improved; indexing; innovation; insight; mechanical allodynia; multidisciplinary; nerve supply; new technology; novel; painful neuropathy; patient oriented; patient oriented research; programs; research study; response; somatosensory; sound

DESCRIPTION (provided by applicant): This K24 proposal is a request for support for patient-oriented mentoring in the domain CNS mechanisms in pain and analgesic processing in humans. Pain continues to be a significant health problem in the US and functional imaging has already changed the domain of our insights into pain processing by providing novel insights into CNS plasticity, degeneration, and novel circuitry involved in pain processing in health and disease. Training of young scientists in a manner that provides a sound solid and supportive environment in an integrated, multidisciplinary program within the Harvard system will contribute to future enrollment of scientists in this domain. The proposal outlines a plan for mentoring that relates to 4 aspects of ongoing research in our pain and analgesia imaging neurosicence (p.a.i.n.) group at Harvard and include: (1) Mechanisms of Human Disease (e.g., migraine and trigeminal pain; pediatric pain); (2) Development of New Technologies (e.g., technologies for objective measures in the operating room); (3) Therapeutic Interventions (e.g., novel drug evaluation); and (4) Clinical Trials using fMRI. In addition the proposal defines specific training components that would enhance his mentoring abilities that include management courses and courses in cognitive sciences at the Massachusetts Institute of Technology and Harvard University. The candidate a track record in mentoring both clinicians and basic scientists, including K awards, and have a strong network of collaborators involved in our research program. The applicant is fully committed to mentoring and is in a very good position to do this at this point in his career. Providing objective indices of pain and analgesia would be a significant step forward in alleviating pain and suffering and the development of analgesics.

描述（由申请人提供）：本K24提案旨在支持在人类疼痛和镇痛处理的CNS机制领域中以患者为导向的指导。在美国，疼痛仍然是一个重要的健康问题，功能成像已经改变了我们对疼痛处理的见解，通过提供对CNS可塑性、变性和健康和疾病中疼痛处理所涉及的新回路的新见解。在哈佛系统内的一个综合性、多学科方案中，以提供一个健全、坚实和支持性环境的方式培训青年科学家，将有助于今后在这一领域招收科学家。该提案概述了指导计划，涉及我们疼痛和镇痛成像神经科学（p.a.i.n.）正在进行的研究的4个方面。组在哈佛和包括：（1）人类疾病的机制（例如，偏头痛和三叉神经痛;儿科疼痛）;（2）新技术的发展（例如，用于手术室中的客观测量的技术）;（3）治疗性干预（例如，新药评价）;和（4）使用fMRI的临床试验。此外，该提案还确定了具体的培训内容，以提高他的指导能力，包括马萨诸塞州理工学院和哈佛大学的管理课程和认知科学课程。候选人在指导临床医生和基础科学家方面有良好的记录，包括K奖，并在我们的研究项目中拥有强大的合作者网络。申请人完全致力于指导，并且在他职业生涯的这一点上处于非常有利的位置。提供疼痛和止痛的客观指数将是在减轻疼痛和痛苦以及开发止痛剂方面向前迈出的重要一步。