Multimodal Brain Measures of Migraine with Age: Prepuberty to Adult

描述（由申请人提供）：大约有3000万美国人患有偏头痛。偏头痛是一种潜在的慢性进行性疾病，严重影响患者，家庭，工作场所和社会。超过20%的偏头痛在10岁之前开始，45%在20岁之前开始，并且可以在4岁的儿童中出现。它以前被认为是一种发作性疾病，但现在被认为是一种影响大脑的进行性疾病，对个人生活的各个方面产生负面影响 特别是在成长和生产的年代。在这里，我们建议使用多模式的方法脑成像方法来评估功能，形态（灰质体积和白色物质的完整性）和化学变化的急性发作性偏头痛从7至27岁的队列的大脑。通过使用发展（年龄）来处理这个问题，我们建议证明：（1）男性和女性偏头痛患者在不同年龄（青春期前，青春期，和年轻的成年人队列）有显着不同的大脑处理与对照组相比;（2）大脑变化的进展可能会分化，并提供新的见解，在青春期/青春期女性大脑的变化;以及（3）偏头痛对年轻大脑（青春期前）的影响的测量可以提供对与激素效应无关的偏头痛相关的核心大脑变化的见解。我们希望测试偏头痛大脑中存在与年龄相关的差异相似性的假设， 这些变化可以预测疾病的长期持续时间/过程。我们在影像学、偏头痛神经生物学和神经学方面拥有必要的专业知识，并为拟议研究的每个方面提供了初步数据。我们期望获得关于偏头痛大脑如何呈现衰老的见解，这可能提供新的治疗方法，特别是在年轻时，当疾病在大量个体中开始时。

DESCRIPTION (provided by applicant): Approximately 30 million Americans suffer from migraine headaches. Migraine is a potentially chronic, progressive disease that substantially affects patients, families, workplaces, and society. More than 20% of migraine headaches start before the age of 10 and 45% before the age of 20 and can appear in children as young as 4 years old. It has previously been considered an episodic disorder, but now is thought to be a progressive disease affecting the brain that negatively affects all aspects of an individual's life particularly during formative and productive years. Here we propose to use multimodal approaches brain imaging approaches to evaluate functional, morphometric (gray matter volume and white matter integrity) and chemical changes in the brains of cohorts of acute episodic migraineurs from 7 to 27 years of age. By approaching he problem using development (age), we propose to demonstrate: (1) that male and female migraineurs at different ages (prepubertal, pubertal, and young adult cohorts) have significantly different brain processing compared with controls; (2) that progression of brain changes may differentiate and provide novel insights into changes in the female brain during puberty/adolescence; and (3) that measures of migraine effects on the young brain (prepubertal) may provide insights into core brain changes involved in migraine independent of hormonal effects. We wish to test the hypotheses that there are age-related differences similarities in the migraine brain and that early changes may predict the long duration/course of the disease. We have the necessary expertise in imaging, migraine neurobiology and neurology, and preliminary data for each aspect of the proposed research. We expect to gain insights on how the migraine brain presents with ageing that may provide novel approaches to therapy particularly at a young age when the disease begins in a significant number of individuals.