Multimodal Brain Measures of Migraine with Age: Prepuberty to Adult

描述(由申请人提供)：大约3000万美国人患有偏头痛。偏头痛是一种潜在的慢性进行性疾病，对患者、家庭、工作场所和社会都有很大影响。超过20%的偏头痛开始于10岁之前，45%的偏头痛开始于20岁之前，而且可能出现在4岁以下的儿童身上。它以前被认为是一种间歇性疾病，但现在被认为是一种影响大脑的进行性疾病，对个人生活的方方面面都有负面影响 特别是在形成期和生产期。在这里，我们建议使用多模式方法脑成像方法来评估7至27岁的急性发作性偏头痛患者的脑功能、形态计量(灰质体积和白质完整性)和化学变化。通过使用发育(年龄)来解决这个问题，我们建议证明：(1)不同年龄的男性和女性偏头痛患者(青春期前、青春期和青年组)的大脑处理与对照组相比有显著差异；(2)大脑变化的进展可能会有所区别，并为女性在青春期/青春期期间的大脑变化提供新的见解；以及(3)偏头痛对年轻大脑(青春期前)影响的测量可能提供对偏头痛核心大脑变化的洞察，而不受激素影响。我们希望验证这样的假设，即偏头痛的大脑和早期存在与年龄相关的差异和相似性。 变化可以预测疾病的长期/病程。我们在成像、偏头痛神经生物学和神经学方面拥有必要的专业知识，并为拟议研究的每个方面提供了初步数据。我们希望获得有关偏头痛大脑如何随年龄增长的见解，这可能为治疗提供新的方法，特别是在疾病开始在相当多的人中出现的年轻时期。

DESCRIPTION (provided by applicant): Approximately 30 million Americans suffer from migraine headaches. Migraine is a potentially chronic, progressive disease that substantially affects patients, families, workplaces, and society. More than 20% of migraine headaches start before the age of 10 and 45% before the age of 20 and can appear in children as young as 4 years old. It has previously been considered an episodic disorder, but now is thought to be a progressive disease affecting the brain that negatively affects all aspects of an individual's life particularly during formative and productive years. Here we propose to use multimodal approaches brain imaging approaches to evaluate functional, morphometric (gray matter volume and white matter integrity) and chemical changes in the brains of cohorts of acute episodic migraineurs from 7 to 27 years of age. By approaching he problem using development (age), we propose to demonstrate: (1) that male and female migraineurs at different ages (prepubertal, pubertal, and young adult cohorts) have significantly different brain processing compared with controls; (2) that progression of brain changes may differentiate and provide novel insights into changes in the female brain during puberty/adolescence; and (3) that measures of migraine effects on the young brain (prepubertal) may provide insights into core brain changes involved in migraine independent of hormonal effects. We wish to test the hypotheses that there are age-related differences similarities in the migraine brain and that early changes may predict the long duration/course of the disease. We have the necessary expertise in imaging, migraine neurobiology and neurology, and preliminary data for each aspect of the proposed research. We expect to gain insights on how the migraine brain presents with ageing that may provide novel approaches to therapy particularly at a young age when the disease begins in a significant number of individuals.