MECP2 POLYMORPHISMS IN SLE

SLE 中的 MECP2 多态性

• 批准号: 8359796
• 负责人: Amr H Sawalha
• 金额: $ 13.96万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359796
• 关键词: Affect; Autoimmunity; Biological Assay; DNA; DNA Resequencing; Funding; Genes; Genetic; Grant; Haplotypes; Individual; Molecular; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Risk; Series; Source; Systemic Lupus Erythematosus; United States National Institutes of Health; Variant; case control; chromatin immunoprecipitation; cost; novel; protein complex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this study, resequencing will be used to further characterize the MECP2 gene in individuals with the risk and protective haplotypes, searching for novel variants. These variants will then be assayed in an independent series of cases and controls. Additionally, chromatin immunoprecipitation will be used to determine the affects of these variants on DNA/protein complexes.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在这项研究中，将使用重新测序的方法进一步确定具有风险和保护性单倍型个体的MECP2基因的特征，寻找新的变种。然后将在一系列独立的病例和对照中对这些变种进行检测。此外，染色质免疫沉淀将用于确定这些变体对DNA/蛋白质复合体的影响。