UNDERSTANDING THE ROLE OF ALTERNATIVE SPLICING IN THE TNFAIP3 SLE-RISK ALLELES

了解选择性剪接在 TNFAIP3 SLE 风险等位基因中的作用

• 批准号: 8359795
• 负责人: Mary Beth Humphrey
• 金额: $ 17.22万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359795
• 关键词: Alleles; Alternative Splicing; Autoimmunity; Funding; Genetic; Grant; Haplotypes; Molecular; National Center for Research Resources; Pattern; Principal Investigator; Relative (related person); Research; Research Infrastructure; Resources; Rest; Risk; Role; Source; Systemic Lupus Erythematosus; Transcript; United States National Institutes of Health; cost; genetic variant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. It has recently been discovered that certain genetic variants confer increased risk of developing SLE. This project will define any alternate splicing patterns that may arise from these risk haplotypes, both at rest and under stimulated conditions, and will determine the relative abundance of these alternate transcripts.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 最近发现，某些遗传变异增加了发生SLE的风险。该项目将定义在静止和刺激条件下可能由这些风险单倍型产生的任何选择性剪接模式，并将确定这些选择性转录本的相对丰度。