ShEEP Request for SCANCO microCT

摘要 我们正在申请资金以购买一台Sundio µCT 90台式microCT仪器。该仪器使 研究人员进行高通量，高分辨率microCT扫描，用于广泛的成像研究 应用.通过减少扫描和重建时间以及自动化多达32个样品批次 通过扫描，研究人员将能够解决科学严谨性和可重复性等重要问题。被 能够在更短的时间内以更高的分辨率分析更多的样品（2µM vs 10.5µM） 将使骨骼标本更快地进入组织学组织分析， 微型CT分析的最新成果该技术可以应用于各种其他成像需求， 使用造影剂，将广泛受益于我们的研究人员在老化和关节炎。一种先进 在俄克拉荷马州城市VA卫生保健中心，这样的微型CT成像系统不能用于研究 系统或附属机构，俄克拉荷马州健康科学中心或 俄克拉荷马州医学研究基金会。因此，这种独特的本地资源将提供新的技术， 适用于各种成像需求，这将广泛有利于VA研究人员在老龄化，关节炎， 癌症、免疫学和神经科学研究领域。具体而言，该工具将用于四个主要的 用户和两个小用户谁加起来有五个资助VA优异赠款，以及一些未来的用户。 该工具还将使两个新设立的合作优异奖和两个额外的VA优异奖受益 专注于骨关节炎的临床前模型。

ABSTRACT We are requesting funds to purchase a Scanco µCT 90 desktop microCT instrument. This instrument enables investigators to conduct high-throughput, high-resolution microCT scanning for a wide range of imaging research applications. By reducing time of scanning and reconstruction as well as automating for up to 32 sample batch scanning, investigators will be able to address important issues such as scientific rigor and reproducibility. Being able to analyze a greater number of samples in a shorter period of time with a higher resolution (2µM vs 10.5µM) will allow bone specimens to more quickly move toward histological tissue analysis and prevent the bottle neck of microCT analysis that currently exists. This technology can be applied to various other imaging needs with the use of contrast agents and will broadly benefit our investigators in the aging and arthritis. An advanced microCT imaging system such as this is not available for research use at the Oklahoma City VA Health Care System or at either of the affiliate institutions, the University of Oklahoma Health Sciences Center or the Oklahoma Medical Research Foundation. Thus, this unique local resource will provide new technology that can be applied to a wide variety of imaging needs, which will broadly benefit VA investigators in the aging, arthritis, cancer, immunology, and neuroscience research fields. Specifically, this instrument will be used by four major users and two minor users who combined have five funded VA Merit grants, as well as a number of future users. The instrument will also benefit two newly established Collaborative Merit Awards and two additional VA Merits focused on preclinical models of osteoarthritis.