Reactivity and Regulation in the Intergenerational Transmission of PTSD

项目概述：本项临床科学家导师发展奖（K08）的目的是使候选人能够成为一名独立的研究者，对母亲创伤后应激障碍对养育子女、儿童反应和调节以及创伤应激的代际传递的影响进行综合研究。该奖项的长期目标是为候选人提供信息和设计干预方案，以减轻母亲创伤后应激障碍对儿童的负面影响，并中断创伤后应激障碍的代际传播。为了实现这些目标，候选人将完成一个职业发展计划，重点是提高管理和解释与反应性和调节相关的心理生物学功能的多种测量的能力；创伤应激领域的研究方法，特别强调理解母亲创伤后应激障碍对儿童预后的影响以及创伤后应激障碍代际传播的潜在机制；以及纵向数据收集和统计分析技术。培训将通过课程作业、辅导和专家咨询以及具体的研究项目来完成。研究发展计划的重点是测试母亲创伤后应激障碍对育儿、儿童反应性和自我调节发展的影响的特定模型，这些模型可能是创伤应激代际传递的中介。本研究计划包括两项研究：1)对母亲创伤后应激障碍、父母教养和婴儿第一年反应性和调节能力之间的关系进行前瞻性研究；2)创伤前调节能力在创伤暴露后PTSD发展中的作用的前瞻性分析。通过该奖项获得的培训将使候选人准备提交R01申请，进行一项关于母亲创伤后应激障碍对儿童结局的作用及其潜在影响机制的纵向研究。相关性：本研究将有助于减少母亲创伤后应激障碍对儿童的负面影响，预防创伤应激的代际传播，明确创伤后应激障碍病因的风险和恢复力发展模式，并识别和治疗高危创伤儿童。这项工作还将对理解典型和非典型人群中跨多个系统的自我调节能力的发展以及对有调节困难风险的人群进行干预具有更广泛的意义。

DESCRIPTION (provided by applicant): Project Summary: The purpose of this Mentored Clinical Scientist Development Award (K08) is to enable the candidate to become an independent investigator conducting integrative research on the impact of maternal PTSD on parenting, child reactivity and regulation, and the intergenerational transmission of traumatic stress. The long-term goal of this award is to prepare the candidate to inform and design intervention programs that mitigate the negative impact of maternal PTSD on children and interrupt the integenerational transmission of PTSD. To accomplish these goals, the candidate will complete a career development plan focused on promoting competence in the administration and interpretation of multiple measures of psychobiological functioning relevant to reactivity and regulation; methodology in the field of traumatic stress, with a particular emphasis on understanding the effects of maternal PTSD on child outcome and potential mechanisms involved in the intergenerational transmission of PTSD; and longitudinal data collection and statistical analysis techniques. Training will be accomplished via coursework, tutorials and consultation with experts, and specific research projects. The research development plan is focused on testing a specific model of the impact of maternal PTSD on parenting, child reactivity, and the development of self-regulation as potential mediators in the intergenerational transmission of traumatic stress. The research program consists of two studies: 1) a prospective examination of associations among maternal PTSD, parenting, and infant reactivity and regulatory abilities in the first year; and 2) a prospective analysis of the role of pre- trauma regulation abilities in the development of PTSD following trauma exposure. Training obtained via this award will prepare the candidate to submit an R01 application for a longitudinal study of the role of maternal PTSD on child outcome and potential underlying mechanisms of effects. Relevance: This work will help inform intervention efforts to mitigate the negative impact of maternal PTSD on children, prevent the intergenerational transmission of traumatic stress, specify developmental models of risk and resilience in the etiology of PTSD, and identify and treat at-risk traumatized children. This work will also have more general implications for understanding the development of self-regulatory abilities across multiple systems in typical and atypical populations and for intervening with populations at risk for regulatory difficulties.