Faculty Recruitment into Neurobiology of Addiction Research Center (NARC)

描述（由申请人提供）：本申请是对RFA-OD-09-005的回应，标题为“恢复法案有限竞争：支持新的教师招聘，通过生物医学研究核心中心（P30）增强研究资源。 成瘾神经生物学研究中心（NARC）联合了一批在行为，神经化学，电生理学，细胞生物学，神经成像和临床试验方面具有专业知识的研究人员。建议在查尔斯顿的南卡罗来纳州医科大学神经科学系招聘一名终身助理教授。申请人Peter Kalivas博士是NARC主任和神经科学系主任。虽然NARC是通过神经科学系管理的，但14个主要的终身教职教师都在神经科学和精神病学两个系。拟议的招聘，博士亚瑟里格尔，是一个有成就的神经生理学家，目前由一个KOI奖从NIDA在神经科学系的非终身助理教授的位置资助。NARC目前在里格尔博士的两个专业领域缺乏或只有最小的研究能力，即全细胞膜片膜生理学和活细胞多光子成像和记录。特别是，国家癌症研究机构的组合中完全缺乏后一种专门知识。因此，里格尔博士的招聘将建立一个设施，进行活细胞成像，可以与NARC的其他成员分享。里格尔博士将对接受可卡因自我给药训练的大鼠进行研究，研究代谢型谷氨酸受体和促肾上腺皮质激素释放因子对多巴胺神经元离子通道的调节所产生的持久神经适应性。这些动物将主要来自NARC维持的动物核心，该中心训练动物自我服用可卡因和海洛因。 神经科学系保证，如果被任命，里格尔博士将保留他的任命，基本工资和实验室空间至少5年，包括拟议的P30资金的2年。

DESCRIPTION (provided by applicant): This application is in response to RFA-OD-09-005, title 'Recovery act limited competition: Supporting new faculty recruitment to enhance research resources through biomedical research core centers (P30). The Neurobiology of Addiction research Center (NARC) unites an assemblage of investigators with expertise in behavior, neurochemistry, electrophysiology, cell biology, neuroimaging and clinical trials. It is proposed to recruit a tenure-track Assistant Professor into the NARC with a primary faculty appointment in the Department of Neurosciences at the Medical University of South Carolina, Charleston. The applicant, Dr. Peter Kalivas, is both director of the NARC and chair of the department of Neurosciences. Although the NARC is administered through the Department of Neurosciences, the 14 primary tenure-track faculty are in both departments of Neurosciences and Psychiatry. The proposed recruit, Dr. Arthur Riegel, is an accomplished neurophysiologist currently funded by a KOI award from NIDA in a position of non-tenure track Assistant Professor in the department of Neurosciences. The NARC presently lacks or has minimal research capacity in two areas of Dr. Riegel's expertise, whole cell patch membrane physiology and live cell multiphoton imaging and recording. In particular, the latter expertise is entirely lacking from the NARC portfolio. Thus, Dr. Riegel's recruitment will establish a facility to conduct live cell imaging that can be shared in part with other members of the NARC. Dr. Riegel will conduct research into the enduring neuroadaptations produced in the regulation of ion channels in dopamine neurons by metabotropic glutamate receptors and corticotropin releasing factor in rats trained to self-administer cocaine. The animals will be derived largely from the animal core maintained by the NARC that trains animals to self-administer cocaine and heroin. The department of Neurosciences guarantees that if appointed, Dr. Riegel will retain his appointment, base salary and laboratory space for a minimum of 5 years, including the 2 years of the proposed P30 funding.