Faculty Recruitment into Neurobiology of Addiction Research Center (NARC)

描述(申请人提供)：本申请是针对RFA-OD-09-005，题为《复苏法案限制竞争：支持招聘新教师以通过生物医学研究核心中心提升研究资源》(P30)。 成瘾研究中心的神经生物学(NARC)联合了一批在行为、神经化学、电生理学、细胞生物学、神经成像和临床试验方面具有专业知识的研究人员。建议为NARC招聘一名终身教职助理教授，并在查尔斯顿南卡罗来纳医科大学神经科学系担任初级教师。申请者彼得·卡利瓦斯博士既是NARC主任，也是神经科学系主任。尽管NARC是通过神经科学系管理的，但14名初级终身教职教师同时在神经科学系和精神病学系。拟招聘的Arthur Riegel博士是一位有成就的神经生理学家，目前由NIDA颁发的KOI奖资助，在神经科学系担任非终身教职助理教授。NARC目前在Riegel博士的两个专业领域缺乏或几乎没有研究能力，这两个领域是全细胞膜片生理学和活细胞多光子成像和记录。特别是，NARC的投资组合完全缺乏后者的专业知识。因此，Riegel博士的招募将建立一个进行活细胞成像的设施，可以部分与NARC的其他成员共享。里格尔博士将对接受过自我注射可卡因训练的大鼠进行研究，通过代谢性谷氨酸受体和促肾上腺皮质激素释放因子调节多巴胺神经元中的离子通道，从而产生持久的神经适应。这些动物将主要来自NARC维护的动物核心，该中心训练动物自我给药可卡因和海洛因。 神经科学系保证，如果被任命，Riegel博士将保留他的任命、基本工资和实验室空间至少5年，包括拟议的P30资助的2年。

DESCRIPTION (provided by applicant): This application is in response to RFA-OD-09-005, title 'Recovery act limited competition: Supporting new faculty recruitment to enhance research resources through biomedical research core centers (P30). The Neurobiology of Addiction research Center (NARC) unites an assemblage of investigators with expertise in behavior, neurochemistry, electrophysiology, cell biology, neuroimaging and clinical trials. It is proposed to recruit a tenure-track Assistant Professor into the NARC with a primary faculty appointment in the Department of Neurosciences at the Medical University of South Carolina, Charleston. The applicant, Dr. Peter Kalivas, is both director of the NARC and chair of the department of Neurosciences. Although the NARC is administered through the Department of Neurosciences, the 14 primary tenure-track faculty are in both departments of Neurosciences and Psychiatry. The proposed recruit, Dr. Arthur Riegel, is an accomplished neurophysiologist currently funded by a KOI award from NIDA in a position of non-tenure track Assistant Professor in the department of Neurosciences. The NARC presently lacks or has minimal research capacity in two areas of Dr. Riegel's expertise, whole cell patch membrane physiology and live cell multiphoton imaging and recording. In particular, the latter expertise is entirely lacking from the NARC portfolio. Thus, Dr. Riegel's recruitment will establish a facility to conduct live cell imaging that can be shared in part with other members of the NARC. Dr. Riegel will conduct research into the enduring neuroadaptations produced in the regulation of ion channels in dopamine neurons by metabotropic glutamate receptors and corticotropin releasing factor in rats trained to self-administer cocaine. The animals will be derived largely from the animal core maintained by the NARC that trains animals to self-administer cocaine and heroin. The department of Neurosciences guarantees that if appointed, Dr. Riegel will retain his appointment, base salary and laboratory space for a minimum of 5 years, including the 2 years of the proposed P30 funding.