Faculty Recruitment into Neurobiology of Addiction Research Center (NARC)

描述（由申请人提供）：本申请是对 RFA-OD-09-005 的回应，标题为“恢复法案有限竞争：支持新教师招聘，通过生物医学研究核心中心增强研究资源”(P30)。 成瘾神经生物学研究中心 (NARC) 汇集了一群在行为、神经化学、电生理学、细胞生物学、神经影像学和临床试验方面具有专业知识的研究人员。建议在 NARC 招聘一名终身教授助理教授，并在查尔斯顿南卡罗来纳医科大学神经科学系担任主要教员。申请人Peter Kalivas博士是NARC主任兼神经科学系主任。尽管 NARC 通过神经科学系进行管理，但 14 名主要终身教职人员均来自神经科学系和精神病学系。拟聘用的 Arthur Riegel 博士是一位颇有成就的神经生理学家，目前由 NIDA 的 KOI 奖资助，担任神经科学系的非终身教授助理教授。 NARC 目前在 Riegel 博士的专业知识的两个领域缺乏或只有很少的研究能力，即全细胞膜片生理学和活细胞多光子成像和记录。特别是，NARC 产品组合中完全缺乏后者的专业知识。因此，Riegel 博士的招募将建立一个进行活细胞成像的设施，该设施可以与 NARC 的其他成员部分共享。 Riegel 博士将研究在经过自我注射可卡因训练的大鼠中，代谢型谷氨酸受体和促肾上腺皮质激素释放因子对多巴胺神经元离子通道的调节所产生的持久神经适应。这些动物将主要来自 NARC 维护的动物核心，该中心训练动物自我注射可卡因和海洛因。 神经科学系保证，如果任命，Riegel 博士将保留其任命、基本工资和实验室空间至少 5 年，其中包括拟议的 P30 资助的 2 年。

DESCRIPTION (provided by applicant): This application is in response to RFA-OD-09-005, title 'Recovery act limited competition: Supporting new faculty recruitment to enhance research resources through biomedical research core centers (P30). The Neurobiology of Addiction research Center (NARC) unites an assemblage of investigators with expertise in behavior, neurochemistry, electrophysiology, cell biology, neuroimaging and clinical trials. It is proposed to recruit a tenure-track Assistant Professor into the NARC with a primary faculty appointment in the Department of Neurosciences at the Medical University of South Carolina, Charleston. The applicant, Dr. Peter Kalivas, is both director of the NARC and chair of the department of Neurosciences. Although the NARC is administered through the Department of Neurosciences, the 14 primary tenure-track faculty are in both departments of Neurosciences and Psychiatry. The proposed recruit, Dr. Arthur Riegel, is an accomplished neurophysiologist currently funded by a KOI award from NIDA in a position of non-tenure track Assistant Professor in the department of Neurosciences. The NARC presently lacks or has minimal research capacity in two areas of Dr. Riegel's expertise, whole cell patch membrane physiology and live cell multiphoton imaging and recording. In particular, the latter expertise is entirely lacking from the NARC portfolio. Thus, Dr. Riegel's recruitment will establish a facility to conduct live cell imaging that can be shared in part with other members of the NARC. Dr. Riegel will conduct research into the enduring neuroadaptations produced in the regulation of ion channels in dopamine neurons by metabotropic glutamate receptors and corticotropin releasing factor in rats trained to self-administer cocaine. The animals will be derived largely from the animal core maintained by the NARC that trains animals to self-administer cocaine and heroin. The department of Neurosciences guarantees that if appointed, Dr. Riegel will retain his appointment, base salary and laboratory space for a minimum of 5 years, including the 2 years of the proposed P30 funding.