Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Disease

总体描述（由申请人提供）： 我们的消化健康中心（DHC）的总体目标：儿科消化系统疾病的临床研究是促进研究，深入了解儿童消化系统疾病的基本过程和致病机制，并产生创新的治疗方法来恢复消化系统健康。我们DHC的目标是促进研究，促进部门间和部门间的合作，以实现消化系统疾病研究的更大临界质量，并专注于转化研究的机会。具体而言，我们的长期目标是通过更好的诊断，治疗和结果来改善儿童健康，我们的四个关键目标重点领域和疾病包括慢性肝病，消化器官（肝脏和肠道）衰竭和移植，炎症和腹泻疾病以及肥胖症。每个重点领域都代表了对儿童消化系统健康具有潜在影响的重要领域，提供了推进国家研究议程的机会，代表了辛辛那提儿童医院医学中心和辛辛那提大学医学院的巨大力量和资源投资领域，并提供了将研究融入患者护理的直接机会。重点领域由三个高度创新的生物医学研究核心，基因表达和测序，生物信息学和综合形态学以及行政核心的临床组成部分联系在一起，以促进以患者为基础的研究。它们共同形成了一个强大的基础设施，该基础设施促进了基于这些复杂GI疾病的遗传学的个性化和预测性医学方法的发展，以及考虑到疾病基本机制的疗法的发展。此外，临床和研究团队已为这些关键重点领域和重要的消化系统疾病中的每一个到位。我们的方法是在整个研究过程中支持基于疾病的研究;在我们的工作模式中，实验室发现产生转化研究机会，从而导致更明确的以患者为导向的研究，如临床试验。除了促进对儿科消化系统疾病的理解外，我们DHC的目标还包括招募既定的研究人员来研究我们的四个重点领域，加强DHC研究人员之间的合作，并鼓励致力于追求儿科消化系统疾病研究事业的年轻研究人员的发展。这些目标是通过试点/可行性奖以及研讨会，讲习班和专题讨论会的丰富计划来促进的。我们成功地作为一个“minicenter”显着扩大研究基地，加强新的合作，发展我们独特的重点，并通过使用生物医学研究核心和获得强大的机构支持，为儿科消化系统疾病的前沿研究做出贡献，这有力地预示着我们作为一个完整的DDRCC取得更大的进展。

DESCRIPTION, OVERALL (provided by applicant): The overall goal of our Digestive Health Center (DHC): Bench-to-Bedside Research in Pediatric Digestive Disease is to promote research that will yield insights into the fundamental processes and pathogenic mechanisms of digestive disease in children and generate innovative treatment to restore digestive health. The aims of our DHC are to foster research and promote interdivisional and interdepartmental collaboration to achieve an even greater critical mass in digestive disease research and to focus on translational research opportunities. Specifically, our long term goals are to improve child health through better diagnosis, treatments and outcomes for our four key targeted focus areas and diseases including Chronic Liver Disease, Digestive Organ (Liver and Intestinal) Failure and Transplantation, Inflammatory and Diarrheal Diseases, and Obesity. Each focus area represents an important area of potential impact on digestive health for children, provides an opportunity to advance the national research agenda, represents an area of tremendous strength and resource investment at Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, and affords a direct opportunity to integrate research into patient care. The focus areas are linked by three highly innovative Biomedical Research Cores, Gene Expression and Sequencing, Bioinformatics, and Integrative Morphology, and by a Clinical Component of the Administrative Core to facilitate patient-based research. Collectively they form a powerful infrastructure that fosters the development of personalized and predictive medical approaches based on the genetics of these complex Gl diseases, and of therapies that take into account basic mechanisms of disease. Moreover, clinical and research teams are in place for each of these key focus areas and important digestive diseases. Our approach is to support disease based research across the continuum of research; in our working model, laboratory discoveries generate translational research opportunities that lead to more definitive patient oriented studies such as clinical trials. In addition to advancing the understanding of pediatric digestive disease, the goals of our DHC include the recruitment of established investigators to the study of our four focus areas, enhancing collaboration among DHC investigators and encouraging the development of young investigators committed to pursuing research careers in pediatric digestive disease. These goals are fostered by Pilot/Feasibility awards as well as an enrichment program of seminars, workshops and symposia. Our success as a "minicenter" in significantly enlarging the Research Base, enhancing new collaborations, developing our unique focus and contributing to cutting edge research in pediatric digestive disease by the use of the Biomedical Research Cores and obtaining strong institutional support is strongly predictive of our even greater progress as a full DDRCC.