Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Diseas

总体描述（由申请人提供）：我们的消化健康中心（DHC）的总体目标：儿科消化疾病的临床研究是促进研究，从而深入了解儿童消化系统疾病的基本过程和致病机制，并产生创新的治疗方法来恢复消化系统健康。DHC的第一个奖励期非常成功，核心服务不断发展，以满足创新研究人员的科学需求，研究基地显着增长到85名研究人员和3570万美元的校外消化系统疾病相关资金。试点和可行性（P/F）奖，过渡到R 01赠款，和一个动态的丰富系列。这一成功的轨迹将在未来几年通过促进研究和促进部门间和部门间的合作来追求，以保持消化系统疾病研究的坚实临界质量，重点是转化研究。具体而言，我们的长期目标是通过更好的诊断，治疗和结果来改善儿童健康，我们的四个关键目标重点领域和疾病：1）慢性肝病，2）炎症和消化系统疾病，3）肥胖和消化系统，以及4）发育和消化系统疾病。每个重点领域都为儿童的消化健康带来了潜在影响的机会，有助于推进国家研究议程，并创造了一个独特的环境，将研究融入患者护理。重点领域由三个高度创新的生物医学研究核心（1。基因和蛋白质表达，2。生物信息学，3。综合形态学）和行政核心的临床组成部分，以促进以病人为基础的研究。它们共同形成了一个强大的基础设施，该基础设施促进了基于GI疾病的遗传学和分子基础的个性化和预测性医学方法的发展，以及考虑到疾病基本机制的疗法的发展。我们的工作模式促进实验室发现，以产生转化研究机会，从而在患者样本中进行验证，然后进行临床试验。除了促进对儿科消化系统疾病的理解，我们DHC的目标还包括通过加强DHC研究者和其他学科研究者之间的合作，为初级研究者提供非常有前途的P/F项目，以及赞助研讨会，讲习班和专题讨论会的动态丰富计划，来招募既定的研究者。这些特点和强大的机构承诺将使DHC能够催化儿科消化系统疾病的转化研究。

DESCRIPTION, OVERALL (provided by applicant): The overall goal of our Digestive Health Center (DHC): Bench-to-Bedside Research in Pediatric Digestive Disease is to promote research that will yield insights into the fundamental processes and pathogenic mechanisms of digestive disease in children and generate innovative treatment to restore digestive health. The first award period of the DHC was very successful, with Core services that evolved to meet the scientific needs of innovative investigators, a remarkable growth of the research base to 85 investigators and $35.7 million of extramural digestive disease-related funds. Pilot and Feasibility (P/F) Awards that transitioned to R01 grants, and a dynamic enrichment series. This trajectory of success will be pursued in future years by fostering research and promoting interdivisional and interdepartmental collaboration to maintain a solid critical mass in digestive disease research, with a focus on translational research. Specifically, our long term goals are to improve child health through better diagnosis, treatments and outcomes for our four key targeted focus areas and diseases: 1) Chronic liver disease, 2) Inflammatory and diarrheal diseases, 3) Obesity and the digestive system, and 4) Development and digestive diseases. Each focus area brings opportunities of potential impact on digestive health for children, helps advance the national research agenda, and creates a unique environment to integrate research into patient care. The focus areas are linked by three highly innovative Biomedical Research Cores (1. Gene and Protein Expression, 2. Bioinformatics, and 3. Integrative Morphology) and by a Clinical Component of the Administrative Core to facilitate patient-based research. Collectively they form a powerful infrastructure that fosters the development of personalized and predictive medical approaches based on the genetics and molecular basis of Gl diseases, and of therapies that take into account basic mechanisms of disease. Our working model promotes laboratory discoveries to generate translational research opportunities that lead to validation in patient samples and is followed by clinical trials. In addition to advancing the understanding of pediatric digestive disease, the goals of our DHC include the recruitment of established investigators to the field by enhancing collaboration among DHC investigators and investigators from other disciplines, by funding highly promising P/F Projects for junior investigators, and by sponsoring a dynamic enrichment program of seminars, workshops and symposia. These features and a strong institutional commitment will enable the DHC to catalyze translational research in pediatric digestive disease.