Cell and Molecular Biology Core

细胞和分子生物学核心

• 批准号: 8109206
• 负责人: RICHARD A ALTSCHULER
• 金额: $ 24.74万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8109206
• 关键词: Address; Animals; Area; Arts; Brain; Cells; Collaborations; Consult; Consultations; Data; Data Analyses; Databases; Development; Education; Equilibrium; Experimental Designs; Eye; Gene Delivery; Genes; Goals; Grant; Hearing; Individual; Intervention; Laboratories; Labyrinth; Measures; Methodology; Methods; Michigan; Molecular; Molecular Biology; Outcome; Peptides; Pharmaceutical Preparations; Physiological; Physiology; Productivity; Reagent; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Services; Site; System; Technology; Testing; Therapeutic Studies; Training; Universities; Work; auditory pathway; base; clinical application; design; experience; falls; hearing impairment; innovation; innovative technologies; insight; investigator training; meetings; mouse model; novel; prevent; research study; small molecule; success; technology development

The goal of the Cell & Molecular Biology (CMB) Core is to enhance and extend the quality and scope of individual research projects, by providing access to molecular technologies and measures that will yield insights into the molecular basis for hearing and hearing impairment. To achieve this goal the CMB Core has Specific Aims that fall into four areas: Development, Education, Collaboration and Service. In Development, the CMB will bring new methods and approaches to individual investigators and develop technology and data bases to facilitate use of the mouse model. In Education, the CMB will provide information on new advances in methodology to individual investigators, train staff of individual investigators in both routine and novel molecular methodologies, provide a bridge to centralized University of Michigan facilities for novel and advanced methodologies, and hold monthly meetings of Core Discussion Group with outside experts on specific topics to introduce new methods and approaches, share experiences, problems and successes and develop new productive collaborations. This last goal will be expanded In Collaborations, in which the CMB will bring new investigators to the study of hearing and balance research, bring in outside experts for new directions and approaches, and provide a format for discussions leading to new areas and directions of research. For Service, the CMB will provide state-of-the-art support for morphological and molecular assessments, provide assistance in integration of morphological and molecular assessments, provide normative data bases and provide assistance in experimental design and interpretation of results. The CMB Core will also work closely with the Physiology Core and the Delivery Core to coordinate physiological and morphological characterization of animals at both the molecular and systems level to enhance our understanding of hearing and to define molecular interventions that will prevent and treat hearing loss.

细胞和分子生物学（CMB）核心的目标是提高和扩大质量和范围， 个别研究项目，通过提供获得分子技术和措施， 深入了解听力和听力障碍的分子基础。为了实现这一目标，CMB核心 有具体的目标，分为四个领域：发展，教育，合作和服务。在 发展，商业银行管理局将为个人研究者带来新的方法和途径，并发展 技术和数据库，以方便使用的小鼠模型。在教育方面，中巴将提供 向调查员提供关于方法新进展的信息，培训调查员工作人员 在常规和新型分子方法学方面，为密歇根大学提供了一座桥梁 为新的和先进的方法提供设施，并每月举行核心讨论小组会议， 外部专家就具体专题介绍新的方法和做法，分享经验， 并发展新的富有成效的合作。最后一个目标将在 合作，其中CMB将带来新的研究人员的听力和平衡研究的研究， 引入外部专家，以确定新的方向和方法，并提供一种讨论形式， 新的研究领域和方向。在服务方面，CMB将提供最先进的支持， 形态学和分子学评估，为形态学和分子学的整合提供帮助。 评估，提供规范性数据库，并在实验设计中提供帮助， 结果的解释。 CMB核心还将与生理学核心和交付核心密切合作， 在分子和系统水平上对动物进行生理和形态学表征， 提高我们对听力的理解，并确定预防和治疗听力障碍的分子干预措施。 听力损失