Pathology of the Inner Ear: Mechanisms and Treatment

描述（由申请人提供）：在过去的十年中，我们见证了在耳病理学的预防和康复方面令人兴奋的进展。对潜在机制的进一步了解正在迅速导致新的和有效的干预措施的发展。预防药物和噪音引起的听力损失的临床试验最近结束或正在进行，这是第一次。目前最有效的康复技术——人工耳蜗已经成熟，并正在向新的领域扩展，而包括分子医学在内的替代治疗范式也开始在动物实验中显示出希望。因此，召开一次会议，汇集基础、转化和临床研究人员以及临床医生，以严格审查这些发展并展望未来，是及时的。我们建议举行为期两天的会议，包括平台展示、海报和正式和非正式讨论的时间，以便：1)提供对广泛和未解决的耳病理的分子机制的理解；2)分析这些机制的共同主题和差异；3)探索如何利用对基本原理的理解来开发有针对性的治疗方法；4)让研究人员和临床医生熟悉彼此的目标和问题，5)讨论加速基础研究向临床转化的机会，6)在学生、住院医生和实习生中建立对内耳疾病的认识，以及研究和临床努力的现状，为未来的职业和合作奠定基础。这次会议的一个主要目标是增加跨学科和病理之间的对话和交流。因此，演讲者代表并将介绍基础研究、转化研究和临床考虑。此外，除了对最近和相关结果的多学科介绍外，会议的目的将是鼓励与更广泛的听觉，前庭和临床社区进行讨论，海报会议将是一个适当的工具。会议将在《听力研究》的特刊上发表演讲嘉宾的评论和文章，为未来的发展提供新的思路和领域，为合作提供机会，并促进研究成果转化为临床甚至潜在的商业应用。

DESCRIPTION (provided by applicant): In the last decade we have witnessed exciting advances in the prevention and rehabilitation of otopathologies. An increased understanding of underlying mechanisms is rapidly leading to the development of novel and effective interventions. For the first time, clinical trials on the prevention of drug- and noise-induced hearing loss have either been recently concluded or are under way. The most effective current rehabilitation, cochlear prostheses, has matured and is expanding to new horizons, while alternate treatment paradigms, involving molecular medicine, begin to show promise in animal experiments. It is therefore timely to have a meeting bringing together basic, translational and clinical researchers as well as clinicians to critically review these developments and look to the future. We propose a two day meeting with platform presentations, posters and time for formal and informal discussions to: 1) Provide an understanding of molecular mechanisms underlying widespread and unresolved otopathologies; 2) analyze these mechanisms for common themes as well as differences; 3) explore how an understanding of basic principles can be used to develop targeted treatments; 4) familiarize researchers and clinicians with each others' goals and problems, 5) discuss opportunities to accelerate the translation of basic research to the clinic and 6) create awareness in students, residents and trainees about inner ear disorders and the state of the art of research and clinical endeavors to establish a basis for future careers and collaborations. A primary objective of this conference is to increase the dialogue and cross-fertilization across disciplines and pathologies. The speakers, therefore, represent and will present basic research, translational research and clinical considerations. Furthermore, in addition to a multidisciplinary presentation of recent and relevant results, a purpose of the meeting will be to encourage discussions with the wider auditory, vestibular and clinical community, for which the poster sessions will be an appropriate vehicle. Together with a later publication of reviews and articles by speakers and selected poster presenters in a special issue of Hearing Research, the conference will identify areas of consensus and disagreement, generate new ideas and areas for future development, provide opportunity for cooperation and stimulate translation of research results to clinical and even potential commercial application. PUBLIC HEALTH RELEVANCE: Recent developments in our understanding of the mechanisms underlying some of the most common inner ear pathologies, their prevention and their treatment have made it timely to have a meeting bringing together basic, translational and clinical researchers as well as clinicians to critically review these developments and look to the future. We propose a two day meeting to provide an understanding of molecular mechanisms, to analyze mechanisms for common themes across different inner ear pathologies as well as differences and to examine developments in targeted interventions for prevention and treatment across inner ear disorders.