Clinical Pharmacology Analytical Core

临床药理分析核心(CPAC)协助印第安纳大学西蒙癌症中心(IUSCC) 研究人员支持研究项目和科学目标，CPAC自成立以来 2004年9月，是校园里唯一一个为调查人员提供最先进技术的实验室 对小分子、药物和代谢物进行量化，根据它们的质谱图鉴定化合物，以及 分析药代动力学数据。使用最先进的仪器来量化药物和 对于IUSCC的所有癌症研究人员来说，代谢物是一个宝贵的资源。 CPAC开发和执行分析以识别和/或量化体外药物和代谢物 (包括组织提取物、细胞培养和细胞提取物)和活体研究(包括人类或其他 动物)。它还进行药代动力学分析，描述药物(或代谢物)在 身体一段时间内，从吸收到排泄，以及有关药物暴露的信息。这些服务 最终协助研究人员分析他们关于药代动力学的研究方案， 药效学，药物遗传学，毒性，肿瘤反应和适当的鉴定 个体化治疗。这项技术使IUSCC的研究人员能够做出关键的药物遗传学 已经影响到病人护理的观察结果。

The Clinical Pharmacology Analytical Core (CPAC) assists Indiana University Simon Cancer Center (IUSCC) investigators in support of research projects and scientific goals, CPAC has been in existence since September 2004 and is the only laboratory on campus that provides investigators state-of-the-art technology to quantify small molecules, drugs, and metabolites, to identify compounds based on their mass spectra, and to analyze pharmacokinetic data. Access to state-of-the-art instrumentation for quantification of drugs and metabolites is an invaluable resource for all cancer investigators in the IUSCC. The CPAC develops and performs assays to identify and/or quantify drugs and metabolites from in vitro (including tissue extracts, cell culture and cell extracts) and in vivo studies (including humans or other animals). It also conducts pharmacokinetic analyses that describe drug (or metabolite) concentrations in the body over a period of time, from absorption to excretion, and information on drug exposure. These services ultimately assist investigators in the analysis of their research protocols regarding pharmacokinetics, pharamacodynamics, pharmacogenetics, toxicity, tumor response and identification of appropriate individualized therapies. This technology has allowed IUSCC investigators to make critical pharmacogenetic observations that are already impacting patient care.