Clinical Pharmacology Analytical Core

临床药理学分析核心（CPAC）协助印第安纳州西蒙大学癌症中心（IUSCC） 为了支持研究项目和科学目标，CPAC成立于 2004年9月，是校园里唯一一个为研究人员提供最先进技术的实验室 量化小分子、药物和代谢物，根据质谱鉴定化合物， 分析药代动力学数据。获得最先进的药物定量仪器， 代谢物是IUSCC所有癌症研究人员的宝贵资源。 CPAC开发并执行检测，以识别和/或定量体外培养的药物和代谢物。 （包括组织提取物、细胞培养物和细胞提取物）和体内研究（包括人类或其他 动物）。它还进行药代动力学分析，描述药物（或代谢物）浓度， 身体在一段时间内，从吸收到排泄，以及药物暴露的信息。这些服务 最终协助研究者分析其关于药代动力学的研究方案， 药物动力学、药物遗传学、毒性、肿瘤反应和确定适当的 个性化治疗。这项技术使IUSCC研究人员能够进行关键的药物遗传学研究， 已经影响到病人护理的观察结果。

The Clinical Pharmacology Analytical Core (CPAC) assists Indiana University Simon Cancer Center (IUSCC) investigators in support of research projects and scientific goals, CPAC has been in existence since September 2004 and is the only laboratory on campus that provides investigators state-of-the-art technology to quantify small molecules, drugs, and metabolites, to identify compounds based on their mass spectra, and to analyze pharmacokinetic data. Access to state-of-the-art instrumentation for quantification of drugs and metabolites is an invaluable resource for all cancer investigators in the IUSCC. The CPAC develops and performs assays to identify and/or quantify drugs and metabolites from in vitro (including tissue extracts, cell culture and cell extracts) and in vivo studies (including humans or other animals). It also conducts pharmacokinetic analyses that describe drug (or metabolite) concentrations in the body over a period of time, from absorption to excretion, and information on drug exposure. These services ultimately assist investigators in the analysis of their research protocols regarding pharmacokinetics, pharamacodynamics, pharmacogenetics, toxicity, tumor response and identification of appropriate individualized therapies. This technology has allowed IUSCC investigators to make critical pharmacogenetic observations that are already impacting patient care.