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Clinical Pharmacology Analytical Core

临床药理学分析核心

基本信息

批准号：
7698887
负责人：
David R. Jones
金额：
$ 2.9万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7698887
关键词：
African American Animals Antineoplastic Agents Aromatase Inhibitors Arts Back Basic Science Biological Assay CYP2D6 gene CYP3A4 gene Cancer Center Cancer Center Support Grant Cancer Control Research Caucasians Caucasoid Race Cell Extracts Cells Charge Child Children&apos s Oncology Group Clinic Clinical Clinical Investigator Clinical Pharmacology Collaborations Cultured Cells Data Development Developmental Therapeutics Program Disease-Free Survival Dose Drug Exposure Drug Interactions Drug Kinetics Ensure Enzymes Equipment Excretory function Exemestane Fluoxetine Funding Genetic Polymorphism Germany Goals Grant Head Home environment Hospitals Hot flushes Housing Human In Vitro Indiana Individual Italy Korea Label Laboratories Laboratory Research Lead Letrozole Light Maintenance Malignant Childhood Neoplasm Malignant Neoplasms Mass Spectrum Analysis Measurement Medicine Menopausal hot flushes Mentored Clinical Oncology Award Mentored Clinical Scientist Award Mentored Patient-Oriented Research Career Development Award Metabolism National Institute of General Medical Sciences Nitrogen North Central Cancer Treatment Group Numbers Operative Surgical Procedures Outcome PTK787 Paclitaxel Paroxetine Patient Care Patients Pediatric Oncologist Pharmaceutical Preparations Pharmacogenetics Pharmacogenomics Pharmacology and Toxicology Phase Phase III Clinical Trials Plasma Policies Preparation Protocols documentation Publications Research Research Personnel Research Project Grants Resources Retrospective Studies Risk Saint Jude Children&apos s Research Hospital Sampling Scheme Services Shared Resource Cancer Center Site Spain Structure Support of Research System Tamoxifen Technology Time Tissue Extracts Toxic effect Translations United States Food and Drug Administration Universities Variant Vincristine Woman Work absorption base cancer therapy cost cytochrome P450 3A day design dosage genetic variant in vivo inhibitor/antagonist instrumentation malignant breast neoplasm member microbial alkaline proteinase inhibitor programs research study response small molecule success trial comparing tumor

项目摘要

The Clinical Pharmacology Analytical Core (CPAC) assists Indiana University Simon Cancer Center (IUSCC) investigators in support of research projects and scientific goals, CPAC has been in existence since September 2004 and is the only laboratory on campus that provides investigators state-of-the-art technology to quantify small molecules, drugs, and metabolites, to identify compounds based on their mass spectra, and to analyze pharmacokinetic data. Access to state-of-the-art instrumentation for quantification of drugs and metabolites is an invaluable resource for all cancer investigators in the IUSCC. The CPAC develops and performs assays to identify and/or quantify drugs and metabolites from in vitro (including tissue extracts, cell culture and cell extracts) and in vivo studies (including humans or other animals). It also conducts pharmacokinetic analyses that describe drug (or metabolite) concentrations in the body over a period of time, from absorption to excretion, and information on drug exposure. These services ultimately assist investigators in the analysis of their research protocols regarding pharmacokinetics, pharamacodynamics, pharmacogenetics, toxicity, tumor response and identification of appropriate individualized therapies. This technology has allowed IUSCC investigators to make critical pharmacogenetic observations that are already impacting patient care.

临床药理学分析核心（CPAC）协助印第安纳州西蒙大学癌症中心（IUSCC）为了支持研究项目和科学目标，CPAC成立于 2004年9月，是校园里唯一一个为研究人员提供最先进技术的实验室量化小分子、药物和代谢物，根据质谱鉴定化合物，分析药代动力学数据。获得最先进的药物定量仪器，代谢物是IUSCC所有癌症研究人员的宝贵资源。 CPAC开发并进行检测以识别和/或量化体外药物和代谢物（包括组织提取物、细胞培养物和细胞提取物）和体内研究（包括人类或其他动物）。它还进行药代动力学分析，描述药物（或代谢物）浓度，身体在一段时间内，从吸收到排泄，以及药物暴露的信息。这些服务最终协助研究者分析其关于药代动力学的研究方案，药物动力学、药物遗传学、毒性、肿瘤反应和确定适当的个性化治疗。这项技术使IUSCC研究人员能够进行关键的药物遗传学研究，已经影响到病人护理的观察结果。