Clinical Pharmacology Analytical Core

临床药理学分析核心

基本信息

批准号：
7698887
负责人：
David R. Jones
金额：
$ 2.9万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7698887
关键词：
African American Animals Antineoplastic Agents Aromatase Inhibitors Arts Back Basic Science Biological Assay CYP2D6 gene CYP3A4 gene Cancer Center Cancer Center Support Grant Cancer Control Research Caucasians Caucasoid Race Cell Extracts Cells Charge Child Children&apos s Oncology Group Clinic Clinical Clinical Investigator Clinical Pharmacology Collaborations Cultured Cells Data Development Developmental Therapeutics Program Disease-Free Survival Dose Drug Exposure Drug Interactions Drug Kinetics Ensure Enzymes Equipment Excretory function Exemestane Fluoxetine Funding Genetic Polymorphism Germany Goals Grant Head Home environment Hospitals Hot flushes Housing Human In Vitro Indiana Individual Italy Korea Label Laboratories Laboratory Research Lead Letrozole Light Maintenance Malignant Childhood Neoplasm Malignant Neoplasms Mass Spectrum Analysis Measurement Medicine Menopausal hot flushes Mentored Clinical Oncology Award Mentored Clinical Scientist Award Mentored Patient-Oriented Research Career Development Award Metabolism National Institute of General Medical Sciences Nitrogen North Central Cancer Treatment Group Numbers Operative Surgical Procedures Outcome PTK787 Paclitaxel Paroxetine Patient Care Patients Pediatric Oncologist Pharmaceutical Preparations Pharmacogenetics Pharmacogenomics Pharmacology and Toxicology Phase Phase III Clinical Trials Plasma Policies Preparation Protocols documentation Publications Research Research Personnel Research Project Grants Resources Retrospective Studies Risk Saint Jude Children&apos s Research Hospital Sampling Scheme Services Shared Resource Cancer Center Site Spain Structure Support of Research System Tamoxifen Technology Time Tissue Extracts Toxic effect Translations United States Food and Drug Administration Universities Variant Vincristine Woman Work absorption base cancer therapy cost cytochrome P450 3A day design dosage genetic variant in vivo inhibitor/antagonist instrumentation malignant breast neoplasm member microbial alkaline proteinase inhibitor programs research study response small molecule success trial comparing tumor

项目摘要

The Clinical Pharmacology Analytical Core (CPAC) assists Indiana University Simon Cancer Center (IUSCC) investigators in support of research projects and scientific goals, CPAC has been in existence since September 2004 and is the only laboratory on campus that provides investigators state-of-the-art technology to quantify small molecules, drugs, and metabolites, to identify compounds based on their mass spectra, and to analyze pharmacokinetic data. Access to state-of-the-art instrumentation for quantification of drugs and metabolites is an invaluable resource for all cancer investigators in the IUSCC. The CPAC develops and performs assays to identify and/or quantify drugs and metabolites from in vitro (including tissue extracts, cell culture and cell extracts) and in vivo studies (including humans or other animals). It also conducts pharmacokinetic analyses that describe drug (or metabolite) concentrations in the body over a period of time, from absorption to excretion, and information on drug exposure. These services ultimately assist investigators in the analysis of their research protocols regarding pharmacokinetics, pharamacodynamics, pharmacogenetics, toxicity, tumor response and identification of appropriate individualized therapies. This technology has allowed IUSCC investigators to make critical pharmacogenetic observations that are already impacting patient care.

临床药理学分析核心（CPAC）协助印第安纳大学西蒙癌症中心（IUSCC）研究人员支持研究项目和科学目标，自从CPAC一直存在 2004年9月，是校园唯一提供调查人员最先进技术的实验室量化小分子，药物和代谢产物，以根据其质谱识别化合物，并分析药代动力学数据。使用最新的仪器来量化药物和对于IUSCC的所有癌症研究者来说，代谢产物是宝贵的资源。 CPAC开发和执行测定，以识别和/或量化体外的药物和代谢物（包括组织提取物，细胞培养和细胞提取物）和体内研究（包括人类或其他动物）。它还进行了药代动力学分析，描述了药物（或代谢物）浓度从吸收到排泄的一段时间内的身体以及有关药物暴露的信息。这些服务最终协助研究人员分析其有关药代动力学的研究方案，法拉曼克动力学，药物遗传学，毒性，肿瘤反应和适当的鉴定个性化疗法。这项技术使IUSCC调查人员能够制作关键的药物遗传学已经影响患者护理的观察结果。