PEDIATRIC RHEUMATOLOGY TISSUE REPOSITORY

儿科风湿病组织库

• 批准号: 8098917
• 负责人: SUSAN D THOMPSON
• 金额: $ 8.71万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8098917
• 关键词: Biological; Childhood; Classification; Clinical; Collection; Computer software; Consent; DNA; Disease; Ensure; Genetic; Human Resources; Institution; Liquid substance; Lymphocyte; Muscle; Musculoskeletal; Online Systems; Pamphlets; Patients; Peripheral Blood Lymphocyte; Peripheral Blood Mononuclear Cell; Plasma; Population Research; Process; Protocols documentation; RNA; Research; Research Ethics Committees; Research Personnel; Research Project Grants; Resources; Rheumatology; Sampling; Serum; Shipping; Ships; Site; Specimen; Synovial Fluid; Tissues; Training; Translational Research; Whole Blood; base; biobank; biomedical informatics; clinical research site; immortalized cell; repository; rheumatologist; sample collection; translational study

A Pediatric Rheumatology Tissue Repository (PRTR) is a proposed resource available to investigators of the research base, as well as at the national level for multi-center studies in pediatric rheumatology. This repository provides uniform acquisition and storage of patient and control samples for research purposes. In addition, training is provided to outside centers to ensure smooth and consistent functioning in collection. The principal functions of this Core are: To collect, process and maintain biological specimens from patients with pediatric rheumatological and related musculoskeletal conditions as well as from relevant control populations for research purposes. The types of samples currently primarily include RNA, DNA, synovial fluid, synovial tissue, serum and lymphocytes; To support multi-center collection of patient and control samples nationally. The scope of specimens needed for translational research projects is extensive and can rarely be accomplished without collaborative efforts between multiple clinical investigative sites. The PRTR will assist in establishing sample collection, processing and shipping protocols and coordinate training of clinical site personnel to provide uniform sample collection. The function has been extended beyond the local research base to pediatric rheumatologists at other institutions; To allow systematic access to biological samples for investigators conducting IRB approved basic and translational studies in pediatric rheumatological disease and provide specimens to investigators in appropriate format. This will be done by tracking specimens, study information, consent information and necessary clinical classification within the Biomedical Informatics managed, web-based Biorepository (BR) and integrated Protocol Manager (PM) Software modules.

小儿风湿病学组织存储库（PRTR）是研究人员可用的资源 研究基础以及儿科风湿病学多中心研究的国家一级。 该存储库提供了统一的摄取和存储患者和控制样本进行研究 目的。此外，还向外部中心提供培训，以确保平稳和一致 在集合中运行。 该核心的主要功能是：收集，处理和维持儿科流变学和相关肌肉骨骼状况的患者以及相关控制群体的生物学标本。当前主要包括RNA，DNA，滑液，滑动组织，滑膜组织的类型 血清和淋巴细胞； 支持全国患者和控制样本的多中心收集。范围 翻译研究项目所需的标本是广泛的，很少能完成 没有多个临床调查站点之间的协作努力。 PRTR将协助 建立样本收集，处理和运输协议，并协调临床现场的培训 提供统一样品收集的人员。该功能已扩展到本地 其他机构的小儿风湿病学家研究基础； 为了允许进行IRB批准的小儿风湿病批准的基本和翻译研究的研究人员系统地访问生物样品，并以适当的格式向研究人员提供标本。这将通过跟踪标本，研究信息，同意信息和必要的临床分类来完成。 Biorepository（BR）和集成协议Manager（PM）软件模块。