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The role of chromatin regulation in normal and cancer stem cell self-renawal

The role of chromatin regulation in normal and cancer stem cell self-renawal
染色质调节在正常和癌症干细胞自我更新中的作用
批准号：
8068461
负责人：
THOMAS G FAZZIO
金额：
$24.9万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-06-01 至 2013-05-31
来源：
https://reporter.nih.gov/project-details/8068461
关键词：
ApoptosisAwardBiological AssayCancer cell lineCancerousCell MaintenanceCell NucleusCell ProliferationCell divisionCellsCentromereChromatinChromatin Remodeling FactorChromatin StructureComplexDataDefectDiseaseEnsureEuchromatinGene ExpressionGene TargetingGenesGeneticGenetic TranscriptionGenomeGoalsHematopoietic stem cellsHeterochromatinHumanInstitutionInterphaseKinetochoresLeadLearningLeukemic CellMaintenanceMammalian CellMentorsMetaphaseMethodologyMitosisMolecularMolecular ProfilingMusNuclearPathway interactionsPatternPhasePhenotypePolyploidyPositioning AttributeProcessRNA InterferenceRecombinant DNARegenerative MedicineRegulationResearchRoleScientistStem cellsTechniquesTestingUndifferentiatedXenograft procedurebasecancer stem cellcancer therapycareer developmentcell typecondensindevelopmental plasticityeffective therapyembryonic stem cellflexibilityknock-downleukemiamouse modelmutantnovelpluripotencypreventprogenitorprogramsregenerative therapyresponseself-renewaltherapy developmenttranscription factor

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