The role of chromatin regulation in normal and cancer stem cell self-renawal

染色质调节在正常和癌症干细胞自我更新中的作用

• 批准号: 8076903
• 负责人: THOMAS G FAZZIO
• 金额: $ 24.15万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076903
• 关键词: Apoptosis; Award; Biological Assay; Cancer cell line; Cancerous; Cell Maintenance; Cell Nucleus; Cell Proliferation; Cell division; Cells; Centromere; Chromatin; Chromatin Remodeling Factor; Chromatin Structure; Complex; Data; Defect; Disease; Ensure; Euchromatin; Gene Expression; Gene Targeting; Genes; Genetic; Genetic Transcription; Genome; Goals; Hematopoietic stem cells; Heterochromatin; Human; Institution; Interphase; Kinetochores; Lead; Learning; Leukemic Cell; Maintenance; Mammalian Cell; Mentors; Metaphase; Methodology; Mitosis; Molecular; Molecular Profiling; Mus; Nuclear; Pathway interactions; Pattern; Phase; Phenotype; Polyploidy; Positioning Attribute; Process; RNA Interference; Recombinant DNA; Regenerative Medicine; Regulation; Research; Role; Scientist; Stem cells; Techniques; Testing; Undifferentiated; Xenograft procedure; base; cancer stem cell; cancer therapy; career development; cell type; condensin; developmental plasticity; effective therapy; embryonic stem cell; flexibility; knock-down; leukemia; mouse model; mutant; novel; pluripotency; prevent; progenitor; programs; regenerative therapy; response; self-renewal; stem; therapy development; transcription factor