NEUROPSYCHOLOGICAL INVESTIGATIONS OF PFC-MTL INTERACTIONS IN HUMANS

人类 PFC-MTL 相互作用的神经心理学研究

• 批准号: 8303569
• 负责人: NEAL J. COHEN
• 金额: $ 23.74万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-06 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8303569
• 关键词: Address; Alzheimer' s Disease; Animals; Area; Attention deficit hyperactivity disorder; Behavior; Behavioral; Choice Behavior; Cognitive aging; Data; Dependence; Dependency; Disease; Drug Addiction; Electrodes; Exhibits; Eye; Eye Movements; Functional Magnetic Resonance Imaging; Functional disorder; Health; Hippocampus (Brain); Human; Individual; Investigation; Judgment; Knowledge; Laboratories; Learning; Lesion; Measures; Medial; Memory; Mental disorders; Modeling; Monitor; Monkeys; Nature; Neurons; Patients; Pattern; Performance; Physiology; Rattus; Rodent; Role; Schizophrenia; Testing; Time; Validation; Variant; abstracting; analog; base; interest; network dysfunction; neuroimaging; neuropsychological; relational memory; research study

This project combines neuropsychological, neuroimaging, and eye tracking approaches in order to study the functional interactions of PFC and the hippocampus in supporting richly conditional behavior in humans. The experiments test our hypothesis that the hippocampus is critically involved in relational memory representations whereas PFC is involved in more abstract context-guided associative rules. Neuropsychological studies will provide evidence about the necessity of PFC and MTL regions in relational memory and context-dependent associations, and neuroimaging studies will provide evidence about the nature and timing of functional interactions between these regions. For each study, performance assessments will include not only explicit behavioral judgments but also eye movement-based assessment of memory, pioneered in our laboratory. This approach affords sensitive, implicit nr>easures of the strength of relational and context-dependent representations, based on preferential viewing patterns, as they change dynamically during each trial and across learning and retention. Experiments start with a "base" task in common with all the other empirical projects of the Center, and then graduate to more elaborate variants that systematically manipulate the amount and complexity of relational information or the complexity and abstractness of the context-dependent associative rules to be learned, in order to better determine the dependency of each of these aspects of memory on PFC, hippocampus, and their functional interactions, and further, on the directionality of their interactions.

这个项目结合了神经心理学、神经成像和眼球跟踪的方法，以研究PFC和海马体在支持人类丰富的条件行为方面的功能相互作用。这些实验验证了我们的假设，即海马体关键地参与了关系记忆的表征，而PFC参与了更抽象的上下文引导的关联规则。 神经心理学研究将提供证据证明PFC和MTL区域在关系记忆和上下文相关联系中的必要性，神经成像研究将提供关于这些区域之间功能相互作用的性质和时间的证据。对于每项研究，表现评估不仅包括明确的行为判断，还包括基于眼动的评估 这是我们实验室首创的。这种方法提供了基于偏好观看模式的关系和上下文相关表征的强度的敏感的、隐含的nr&gt；度量，因为它们在每次试验期间以及在学习和保持过程中动态变化。实验从一个与该中心所有其他经验项目相同的“基本”任务开始，然后过渡到更精细的变体，系统地操纵关系信息的数量和复杂性或要学习的上下文相关关联规则的复杂性和抽象性，以便更好地确定记忆的每个方面对PFC、海马体及其功能相互作用的依赖，以及进一步对它们相互作用的方向性的依赖。