Hippocampal System & Relational Memory Processes

描述（由申请人提供）：拟议的工作采用了 多学科的方法来实证检验海马体是 健忘症是关系记忆处理的缺陷。这 记忆处理的一种形式被认为是支持所有方式的记忆。 感知上不同的对象之间的关系，允许记住 事件的构成要素，情况，或场景中遇到的 无论是在日常生活中，还是在实验室里。根据初步工作的结果， 结合眼球运动研究、功能性磁共振成像（fMRI） 研究，以及对患有严重记忆障碍的健忘症患者的研究，我们 我提出了一系列的11项研究，对重复项目的记忆进行抽样 以及对项目之间关系的记忆（关系记忆）。这些研究 操纵要记住的信息的数量和类型， 任务要求、刺激呈现的方式和情境 信息被记住的地方。具体的假设是 在目前的项目中测试的是，健忘症患者选择性地 在需要关系记忆处理的任务中受损，海马 活动选择性地与关系记忆处理相关联， 非关系形式的记忆与大脑系统相关联，而不是与大脑系统相关联。 海马体。这些实验构成了对所声称的联系的强有力的检验 关系记忆处理、健忘症和海马功能之间的联系。他们 这也有助于进一步阐明关系记忆的本质 处理.

DESCRIPTION (provided by applicant): The proposed work employs a multidisciplinary approach to empirically test the idea that the hippocampus is involved in, and amnesia is a deficit in, relational memory processing. This form of memory processing is thought to support memory for all manner of relationships among perceptually distinct objects, permitting remembering of the constituent elements of the events, situations, or scenes encountered in daily life or in the laboratory. Based on results from preliminary work that combines eye movement studies, functional magnetic resonance imaging (fMRI) studies, and studies of amnesic patients with severe memory disorders, we propose a series of 11 studies that sample memory for the repetition of items and memory for the relations among items (relational memory). These studies manipulate the amount and type of information to be remembered, the nature of the task demands, the modality of presentation of the stimuli, and the context in which the information is to be remembered. The specific hypotheses to be tested in the present project are that amnesic patients are selectively impaired on tasks that require relational memory processing, that hippocampal activity is associated selectively with relational memory processing, and that non-relational forms of memory are associated with brain systems other than the hippocampus. These experiments constitute a strong test of the claimed link between relational memory processing, amnesia, and hippocampal function. They should also serve to further clarify the nature of relational memory processing.