Hippocampal System & Relational Memory Processes

描述(由申请人提供)：建议的工作雇用一名 用多学科方法经验性检验海马体 失忆症是一种关系记忆加工的缺陷。这 记忆处理的形式被认为支持所有形式的记忆 感知上不同的物体之间的关系，允许记忆 中遇到的事件、情况或场景的构成要素 日常生活或在实验室里。根据初步工作的结果， 结合眼动研究、功能磁共振成像(FMRI) 对患有严重记忆障碍的健忘症患者的研究，我们 提出了一系列11项研究，以样本记忆重复项目 和用于项之间关系的存储器(关系存储器)。这些研究 操纵要记住的信息的数量和类型、性质 任务要求、刺激的呈现方式和语境 其中的信息将被记住。具体的假设是 在本项目中测试的是健忘症患者选择性地 在需要关系记忆处理的任务中受损，即海马体 活动选择性地与关系存储器处理相关联，并且 非关系形式的记忆与大脑系统相关，而不是 海马体。这些实验构成了对所声称的联系的有力测试 关系记忆处理、健忘症和海马体功能之间的关系。他们 也应该有助于进一步澄清关系记忆的性质 正在处理。

DESCRIPTION (provided by applicant): The proposed work employs a multidisciplinary approach to empirically test the idea that the hippocampus is involved in, and amnesia is a deficit in, relational memory processing. This form of memory processing is thought to support memory for all manner of relationships among perceptually distinct objects, permitting remembering of the constituent elements of the events, situations, or scenes encountered in daily life or in the laboratory. Based on results from preliminary work that combines eye movement studies, functional magnetic resonance imaging (fMRI) studies, and studies of amnesic patients with severe memory disorders, we propose a series of 11 studies that sample memory for the repetition of items and memory for the relations among items (relational memory). These studies manipulate the amount and type of information to be remembered, the nature of the task demands, the modality of presentation of the stimuli, and the context in which the information is to be remembered. The specific hypotheses to be tested in the present project are that amnesic patients are selectively impaired on tasks that require relational memory processing, that hippocampal activity is associated selectively with relational memory processing, and that non-relational forms of memory are associated with brain systems other than the hippocampus. These experiments constitute a strong test of the claimed link between relational memory processing, amnesia, and hippocampal function. They should also serve to further clarify the nature of relational memory processing.