Plant peptides as modulators of invertebrate neurohormone receptors

植物肽作为无脊椎动物神经激素受体的调节剂

• 批准号: FT140100730
• 负责人: A/Prof Christian Gruber
• 金额: $ 38.24万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-08-03 至 2018-02-16
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140100730
• 关键词: Plant; peptides; modulators; invertebrate; neurohormone

Naturally-occurring peptides are widely distributed in many plants, but their biological role is often unclear. Circular plant peptides (called cyclotides) that share similarities with the neuropeptide oxytocin, and acts on its receptor, have been previously isolated. This signalling system is important for reproduction, development, and behaviour as well as water homeostasis. To elucidate the natural function of cyclotides. This project aims to characterise the pharmacological properties and biological effects of invertebrate receptors and their modulation by cyclotides. The notion that plants produce molecules to target invertebrate receptors is extremely appealing and will enhance knowledge about fundamental biological processes of plant-animal ecology.

天然存在的肽广泛分布于许多植物中，但其生物学作用往往不清楚。以前已经分离出与神经肽催产素具有相似性并作用于其受体的环状植物肽（称为环肽）。这种信号系统对于生殖、发育和行为以及水的体内平衡都很重要。阐明环肽类化合物的天然功能。本项目旨在研究无脊椎动物受体的药理学特性和生物学效应以及环肽类化合物对受体的调节作用。植物产生分子靶向无脊椎动物受体的概念是非常有吸引力的，并将提高对植物-动物生态学基本生物过程的认识。