P3-ADULT BONE MARROW STEM CELLS FOR CNS REPAIR

用于中枢神经系统修复的 P3-成人骨髓干细胞

• 批准号: 8168061
• 负责人: JEFFREY L SPEES
• 金额: $ 25.53万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168061
• 关键词: Adult; Apoptosis; Area; Bone Marrow; Bone Marrow Stem Cell; Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Growth Factor; Healed; Human; Inflammatory Response; Injury; Institution; Mediating; Necrosis; Peptides; Perfusion; Proteins; Research; Research Personnel; Resources; Source; Stem cells; Tissues; United States National Institutes of Health; Work; Wound Healing; adult stem cell; angiogenesis; base; cytokine; healing; interest; migration; paracrine; repaired; stem

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent work from our group and others has demonstrated that the benefits of adult stem cell administration are conferred primarily through the paracrine effects of secreted factors. Low numbers of long-term engrafting cells indicate that direct cell replacement is only a small part of what stem/progenitor cells do to heal tissues after injury. Following migration into areas of injury, adult stem cells release numerous growth factors and cytokines that mediate tissue repair by reducing apoptosis and necrosis of surrounding cells, increasing angiogenesis and perfusion, influencing inflammatory responses, and increasing the reparative activities of endogenous tissue stem cells. We have determined that there are subpopulations of human bone marrow-derived progenitor cells with different repertoires of secreted factors. Therefore, it is of interest to determine whether particular subpopulations of bone marrow progenitor cells are best to treat certain injuries based on the proteins and peptides that they release.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们小组和其他人最近的工作表明，成人干细胞管理的好处主要是通过分泌因子的旁分泌作用。 低数量的长期移植细胞表明，直接细胞替代只是干细胞/祖细胞在损伤后愈合组织的一小部分。 在迁移到损伤区域后，成体干细胞释放许多生长因子和细胞因子，其通过减少周围细胞的凋亡和坏死、增加血管生成和灌注、影响炎症反应和增加内源性组织干细胞的修复活性来介导组织修复。 我们已经确定，有不同的人骨髓来源的祖细胞的分泌因子库的亚群。 因此，基于它们释放的蛋白质和肽，确定特定的骨髓祖细胞亚群是否最好地治疗某些损伤是有意义的。