DAYLIGHT DEPENDENT CONTROL OF PROLACTIN SECRETION
催乳素分泌的日光依赖性控制
基本信息
- 批准号:8167715
- 负责人:
- 金额:$ 11.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-01 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:Blood CirculationComputer Retrieval of Information on Scientific Projects DatabaseDataFundingGlandGrantHyperprolactinemiaInstitutionMelatoninNeuronsNeurosecretory SystemsOutputPineal glandPituitary GlandProlactinRegulationResearchResearch PersonnelResourcesReverse Transcriptase Polymerase Chain ReactionSensorySheepSourceSystemTachykininUnited States National Institutes of Healthbasein vivoinsightnovelrelease factor
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The aim of this proposal is to understand the mechanisms by which daylight drives a specific sensory-neuroendocrine system to regulate changes in prolactin secretion. Clear evidence from research on sheep shows that daylight regulates melatonin output from the pineal gland, which in turn, controls prolactin secretion from the pars distalis of the the pituitary gland. This effect is transduced through a specific factor released by the pars tuberalis of the pituitray gland. The identity of this pars tuberalis factor and how it regulates prolactin release is unknown. Based on strong preliminary data, we hypothesize that this factor is a tachykinin. The proposed research will utilize a combination of studies to determine the in vivo secretion of tachykinins into the hypophyseal portal circulation and the effects of tachykinins on prolactin release. Immunocytochemical and RT-PCR studies will establish how daylight, through melatonin, drives changes in the cellular secretory machinery of the pars tuberalis. This research will challenge the prevailing dogma that prolactin regulation is solely driven through factors of neuronal origin. It will provide novel insight into a fundamental sensory-neuroendocrine system and elucidate the specific mechanisms whereby daylight drives this system. It will also generate new insight into potential causes of idiosyncratic hyperprolactinemia, especially those generated by the so-called "stalk-effect".
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
这个建议的目的是了解日光驱动一个特定的感觉神经内分泌系统来调节催乳素分泌变化的机制。对绵羊的研究有明确的证据表明,日光调节松果体的褪黑激素分泌,松果体反过来又控制脑垂体远侧部的催乳素分泌。这种效应是通过垂体结节部释放的一种特殊因子来传导的。这种结节部因子的身份以及它如何调节催乳素的释放尚不清楚。基于强有力的初步数据,我们假设该因子是一种速激肽。拟议的研究将利用一系列研究来确定速激肽在体内分泌到垂体门静脉循环中以及速激肽对催乳素释放的影响。免疫细胞化学和RT-PCR研究将确定日光如何通过褪黑激素驱动结节部细胞分泌机制的变化。这项研究将挑战普遍的教条,催乳素的调节是唯一的驱动因素,神经元起源。它将提供一个基本的感觉神经内分泌系统的新见解,并阐明了日光驱动这个系统的具体机制。它也将产生新的见解特异质高催乳素血症的潜在原因,特别是那些产生的所谓的“茎效应”。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DONAL C SKINNER其他文献
DONAL C SKINNER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DONAL C SKINNER', 18)}}的其他基金
DAYLIGHT DEPENDENT CONTROL OF PROLACTIN SECRETION
催乳素分泌的日光依赖性控制
- 批准号:
7959866 - 财政年份:2009
- 资助金额:
$ 11.24万 - 项目类别:
DAYLIGHT DEPENDENT CONTROL OF PROLACTIN SECRETION
催乳素分泌的日光依赖性控制
- 批准号:
7720471 - 财政年份:2008
- 资助金额:
$ 11.24万 - 项目类别:
DAYLIGHT DEPENDENT CONTROL OF PROLACTIN SECRETION
催乳素分泌的日光依赖性控制
- 批准号:
7609852 - 财政年份:2007
- 资助金额:
$ 11.24万 - 项目类别: