Intermittent Exercise and Symptom Management in Breast Cancer Survivors

描述（由申请人提供）：这是NCI K07职业发展奖的重新提交。勒奈特·克拉夫特博士是一名运动学家，她希望将自己的职业生涯转向癌症预防和控制。她目前的工作重点是使用运动作为临床抑郁症女性的辅助治疗。该奖项将为癌症幸存者提供必要的教育，行为改变策略，评估患者报告的结果，以及在开发运动干预时解决癌症幸存者的特定需求方面的进一步监督和经验。这些机会将支持她进一步的职业发展和她成为一名独立资助的研究者的愿望。主要的共同导师是癌症流行病学家Susan Gapstur博士和临床心理学家和行为医学专家Bonnie Spring博士。癌症患者生活质量测量专家David Cella博士、乳房外科医生Seema Khan医学博士和癌症幸存者运动干预专家Kerry Courneya博士将担任辅助导师。这些赞助者将指导克拉夫特博士的进展；为她的职业发展计划提供监督和支持。罗伯特·h·卢里综合癌症中心和预防医学部全力投入所需的时间和资源，以确保克拉夫特博士的研究工作取得成功。一项随机对照试验旨在探讨间歇性运动干预的可行性和有效性，与标准运动干预和常规护理对照组相比，缓解癌症相关症状（抑郁、疼痛和疲劳），并对辅助治疗后至少6个月的早期乳腺癌女性代谢功能的生物标志物产生积极影响。第二个探索性目的是检查参与不同运动干预导致的久坐行为时间的差异变化。这项研究将解决癌症幸存者面临的一个重要挑战，即确定一种生活方式干预，以减少癌症相关症状，这也将有利于幸存者的身体健康。相关性：本研究将检验标准的和间歇性的运动项目是否能有效地减轻乳腺癌幸存者的疼痛、抑郁和疲劳。此外，这些锻炼项目对幸存者身体健康的益处也将被研究。

DESCRIPTION (provided by applicant): This is a resubmission of an NCI K07 Career Development Award. Lynette Craft, PhD is a kinesiologist seeking to redirect her career to cancer prevention and control. Her current work focuses on the use of exercise as an adjunct treatment for women with clinical depression. The proposed award will provide the necessary education in cancer survivorship, strategies for behavior change, the assessment of patient reported outcomes, as well as further supervision and experience in addressing the specific needs of cancer survivors when developing exercise interventions. These opportunities will support her further career development and her desire to become an independently funded investigator. The primary co-mentors are Dr. Susan Gapstur, PhD, a cancer epidemiologist and Dr. Bonnie Spring, PhD, a clinical psychologist and behavioral medicine expert. David Cella, PhD, an expert in quality of life measurement in cancer patients, Seema Khan, MD, a breast surgeon, and Kerry Courneya, PhD, an expert in developing exercise interventions with cancer survivors will serve as secondary mentors. These sponsors will guide Dr. Craft's progress; provide supervision, and support the activities outlined in her career development plan. The Robert H. Lurie Comprehensive Cancer Center and the Department of Preventive Medicine are fully committed to the time and resources required to assure Dr. Craft success in her research endeavors. A pilot randomized control trial is proposed to explore the feasibility and estimate the effectiveness of an intermittent exercise intervention, as compared to a standard exercise intervention and a usual care control group, to alleviate cancer-related symptoms (depression, pain, and fatigue) and positively impact biomarkers of metabolic function in women with early stage breast cancer who are at least six months post adjuvant treatment. A secondary exploratory aim will examine differential changes in time spent in sedentary behaviors resulting from participation in the different exercise interventions. This research is will address an important challenges facing cancer survivors, that is, identifying a lifestyle intervention to reduce cancer-related symptoms which will also benefit the survivor's physical health. RELEVANCE: This research will examine whether standard and intermittent exercise programs are effective in reducing pain, depression, and fatigue in breast cancer survivors. Further, the physical health benefits of these exercise programs for the survivor will also be studied.