Discovery of Oxaboroles as New Antimalarial Agents

发现氧杂硼杂环戊烯作为新型抗疟药

• 批准号: 8337152
• 负责人: Philip Jon Rosenthal
• 金额: $ 71.81万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8337152
• 关键词: Amino Acyl-tRNA Synthetases; Antimalarials; Antiparasitic Agents; Artemisinins; Award; Back; Blood; Boron; Budgets; California; Chemistry; Child; Collaborations; Communicable Diseases; Cytochrome P450; Development; Dose; Drug Kinetics; Drug effect disorder; Drug resistance; Falciparum Malaria; Funding; Gene Expression Profile; Goals; Human; In Vitro; Knowledge; Label; Lead; Libraries; Malaria; Medicine; Metabolism; Microbe; Modeling; Morphology; Mus; Outcome; Parasites; Pharmaceutical Preparations; Plasmodium falciparum; Population; Pregnant Women; Proteome; Research; Resistance; Safety; San Francisco; Screening procedure; Solubility; Specificity; Staging; Structure-Activity Relationship; Time; Toxicology; United States National Institutes of Health; Universities; artemisinine; base; chemical synthesis; cost effective; cytotoxicity; design; drug discovery; drug metabolism; efficacy evaluation; experience; improved; in vivo; inhibitor/antagonist; insight; meetings; metabolic abnormality assessment; novel; pre-clinical; programs; resistance mechanism; scaffold; scale up; small molecule