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Discovery of Oxaboroles as New Antimalarial Agents

Discovery of Oxaboroles as New Antimalarial Agents
发现氧杂硼杂环戊烯作为新型抗疟药
批准号：
8337152
负责人：
Philip Jon Rosenthal
金额：
$71.81万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-09-30 至 2012-03-31
来源：
https://reporter.nih.gov/project-details/8337152
关键词：
Amino Acyl-tRNA SynthetasesAntimalarialsAntiparasitic AgentsArtemisininsAwardBackBloodBoronBudgetsCaliforniaChemistryChildCollaborationsCommunicable DiseasesCytochrome P450DevelopmentDoseDrug KineticsDrug effect disorderDrug resistanceFalciparum MalariaFundingGene Expression ProfileGoalsHumanIn VitroKnowledgeLabelLeadLibrariesMalariaMedicineMetabolismMicrobeModelingMorphologyMusOutcomeParasitesPharmaceutical PreparationsPlasmodium falciparumPopulationPregnant WomenProteomeResearchResistanceSafetySan FranciscoScreening procedureSolubilitySpecificityStagingStructure-Activity RelationshipTimeToxicologyUnited States National Institutes of HealthUniversitiesartemisininebasechemical synthesiscost effectivecytotoxicitydesigndrug discoverydrug metabolismefficacy evaluationexperienceimprovedin vivoinhibitor/antagonistinsightmeetingsmetabolic abnormality assessmentnovelpre-clinicalprogramsresistance mechanismscaffoldscale upsmall molecule

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