Genetic analyses of salmonella-host interactions

沙门氏菌-宿主相互作用的遗传分析

• 批准号: 8337873
• 负责人: MICAH WORLEY
• 金额: $ 29.85万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2013-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8337873
• 关键词: Accounting; Acute; Affect; Alleles; Animal Model; Bacteria; Binding; Bioterrorism; Blood; Blood Circulation; Categories; Cells; Cessation of life; Coupling; Data; Disease; Disease Reservoirs; Failure; Gallbladder; Genetic; Goals; Health; Homologous Gene; Human; IQ motif containing GTPase activating protein 1; ITGB2 gene; Immune system; Infection; Intestines; Lead; Life; Liver; Logic; Lymphatic; Measures; Mediating; Microbe; Modeling; Molecular; Movement; Multi-Drug Resistance; Mus; National Institute of Allergy and Infectious Disease; Organ; Pathway interactions; Phagocytes; Phenotype; Property; Proteins; Public Health; Regulation; Salmonella; Salmonella infections; Salmonella typhi; Salmonella typhimurium; Septicemia; Site; Spleen; Staging; T-Lymphocyte; Testing; Time; Tissues; Travel; Typhoid Fever; Video Microscopy; Virulence; Work; bile duct; cell motility; filamin; genetic analysis; human BCAR1 protein; in vitro Assay; in vivo; interest; intestinal epithelium; macrophage; microbial; migration; mouse model; mutant; pathogen; research study; resistant strain; weapons

项目成果

A naturally occurring single nucleotide polymorphism in the Salmonella SPI-2 type III effector srfH/sseI controls early extraintestinal dissemination.

沙门氏菌 SPI-2 III 型效应子 srfH/sseI 中天然存在的单核苷酸多态性控制早期肠外传播。

• DOI: 10.1371/journal.pone.0045245
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Thornbrough,JoshuaM;Worley,MicahJ
• 通讯作者: Worley,MicahJ