Evaluation of a new class of antimicrobial agents against Clostridium difficile
Evaluation of a new class of antimicrobial agents against Clostridium difficile
批准号:
8337880
负责人:
Terry L. Bowlin
金额:
$89.79万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-30 至 2013-09-29
关键词:
AcuteAffectAnaerobic BacteriaAnimal ModelAnimalsAnti-Bacterial AgentsAntibiotic TherapyAntibioticsBacteriaBiological AvailabilityCessation of lifeCharacteristicsChemistryChronicClinicClinicalClostridium difficileDNA biosynthesisDNA-Directed DNA PolymeraseDevelopmentDiarrheaDiseaseDoseDrug FormulationsDrug KineticsElderlyEpidemicEuropeEvaluationExhibitsExotoxinsFDA approvedFluoroquinolonesFrequenciesGoalsHamstersHospitalizationHospitalsHybridsIn VitroIncidenceInfectionInflammatory Bowel DiseasesInterventionIntestinesLabelLaboratoriesLarge IntestineLibrariesMediatingMetronidazoleModelingMorbidity - disease rateMusNorth AmericaOralOral AdministrationPatientsPharmaceutical PreparationsPhasePolymersPrecipitating FactorsPreventionProbioticsPseudomembranous ColitisRecurrenceRecurrent diseaseRelapseRequest for ApplicationsSafetyScreening procedureSolubilityTestingTopoisomeraseToxic effectToxicologyToxinToxoidsUracilVaccinesVancomycinWorkabsorptionanalogantimicrobial drugbactericidecapsuledrug administration durationefficacy evaluationfactor Cfluoroquinolone resistanceinhibitor/antagonistmortalitymouse modelnovel therapeutic interventionpotency testingpre-clinicalpreclinical efficacypreclinical evaluationpreclinical safetypreventprototyperesistant strainresponsetreatment strategy
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