Novel dominant-negative HSV-2 recombinant viral vaccines

新型显性失活 HSV-2 重组病毒疫苗

• 批准号: 8333105
• 负责人: FENG YAO
• 金额: $ 50.81万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8333105
• 关键词: Adult; Animal Model; Animals; Antibodies; Antigens; Binding Proteins; CD8B1 gene; Cavia; Cell surface; Cells; Cellular Immunity; Cessation of life; Clinical; Communicable Diseases; DNA biosynthesis; Defective Viruses; Development; Disease; Dominant-Negative Mutation; Effectiveness; Genes; Genital system; Glycoproteins; Goals; HIV; HIV Infections; HSV vector; Herpes Simplex Virus Vaccines; Herpesvirus 1; Human; Human Herpesvirus 2; Immediate-Early Proteins; Immune; Immune response; Immunity; Immunization; Incidence; Individual; Infection; Infectious Agent; Interleukin-15; Laboratories; Light; MHC Class I Genes; Maintenance; Modeling; Mus; Pharmaceutical Preparations; Prevention; Proteins; Recombinant Vaccines; Recombinants; Recurrence; Research; Risk; Safety; Simplexvirus; Subunit Vaccines; Switch Genes; T cell response; Technology; Th1 Cells; Ulcer; United States; Vaccines; Virus Diseases; Virus Replication; clinical efficacy; cost effective; genital herpes; genital infection; immunogenicity; in vivo; latent infection; memory CD4 T lymphocyte; mouse model; mutant; neutralizing antibody; novel; overexpression; polypeptide; pre-clinical; prevent; programs; prophylactic; prototype; recombinant virus; recombinant virus vaccine; response; skin disorder; therapeutic vaccine; vaccine candidate; vaccine efficacy; vector vaccine; vector-based vaccine; viral DNA

项目成果

A herpes simplex virus 2 (HSV-2) glycoprotein D-expressing nonreplicating dominant-negative HSV-2 virus vaccine is superior to a gD2 subunit vaccine against HSV-2 genital infection in guinea pigs.

表达单纯疱疹病毒 2 (HSV-2) 糖蛋白 D 的非复制显性阴性 HSV-2 病毒疫苗在预防豚鼠 HSV-2 生殖器感染方面优于 gD2 亚单位疫苗。

• DOI: 10.1371/journal.pone.0101373
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Zhang,Pengwei;Xie,Lining;Balliet,JohnW;Casimiro,DaniloR;Yao,Feng
• 通讯作者: Yao,Feng