12-lead MRI-Compatible ECG for physiological monitoring and scanner synchronizati

描述(申请人提供)：该SBIR项目旨在开发一种与MRI兼容的12导联心电系统。这样的系统将极大地改善MRI内部的生理监测，这对于对重症患者(中风、脊柱、有缺血史的患者)进行成像非常重要，也是未来MRI引导的干预和手术的关键。目前与MRI兼容的心电监测仅限于4个紧密间隔的电极，主要用于门诊成像。此外，梯度感应(VGrad)和磁流体动力学(VMHD)伪影会扭曲波形，无法可靠地检测急性缺血。12导联系统将去除这些伪影，并提供干净的心电(ECGReal)痕迹，类似于在MRI外测量的痕迹。我们的具体目标是：目标1：兼容磁共振的12导联心电采集和传输我们将开发一个3特斯拉兼容磁共振的心电采集系统，使用10个与磁共振兼容的电极放置在标准躯干位置，并使用同轴电缆传输线将心电信号从电极传输到磁共振 与公共卫生相关：这项研究是相关的，因为在严重疾病和危重护理患者的MRI扫描过程中，难以记录准确的ECG，例如创伤或缺血患者，这导致他们被排除在成像之外。然而，MRI是检测急性中风、急性脊椎损伤和脑梗塞后损害的极佳方法，因此改善的心电图将带来更好的护理。此外，12导联心电图是检测急性缺血的标准检查方法，但缺血指标常常被MRI掩盖。

DESCRIPTION (provided by applicant): This SBIR project aims to develop an MRI-compatible 12-lead ECG system. Such a system will provide greatly improved physiological monitoring inside the MRI, which is important for imaging severely ill patients (stroke, spine, patients with ischemic histories), and is also key to future MRI-guided interventions and surgeries. Current MRI-compatible ECG monitoring is limited to 4-closely spaced electrodes, and is intended mainly for outpatient imaging. In addition, gradient-induction (VGrad) and magneto-hydro-dynamic (VMHD) artifacts distort the waveform, not allowing for reliable acute-ischemia detection. The 12-lead system will remove these artifacts and provide clean ECG (ECGreal) traces, similar to those measured outside MRI. Our Specific Aims are: Aim #1: MR compatible 12-lead ECG acquisition and transmission We will develop a 3 Tesla MR-compatible ECG acquisition system using 10 MRI-compatible electrodes positioned at standard torso locations, with coaxial-cable transmission lines carrying ECG signals from the electrodes to the MRI PUBLIC HEALTH RELEVANCE: This study is relevant due to difficulties in recording accurate ECGs during MRI scanning of severely ill and critical care patients, such as trauma or ischemic patients, which leads to their exclusion from imaging. However, MRI is an excellent modality to detect acute stroke1, acute spinal injury2, and post- infarction damage3, so improved ECG would lead to improved care. Moreover, 12-lead ECG is the standard-of-care for detecting acute ischemia4, but ischemia indicators frequently are masked by MRI