12-lead MRI-Compatible ECG for physiological monitoring and scanner synchronizati

描述（由申请人提供）：该SBIR项目旨在开发MRI兼容的12导联ECG系统。这样的系统将在MRI内部提供大大改进的生理监测，这对于成像重病患者（中风，脊柱，有缺血病史的患者）很重要，也是未来MRI引导的干预和手术的关键。目前MRI兼容的ECG监测仅限于4个紧密间隔的电极，并且主要用于门诊成像。此外，梯度感应（VGrad）和磁流体动力学（VMHD）伪影使波形失真，无法进行可靠的急性缺血检测。12导联系统将消除这些伪影，并提供清晰的ECG（ECGreal）迹线，类似于MRI外测量的迹线。 我们的具体目标是：目标一：MR兼容12导联ECG采集和传输我们将开发一个3 T MR兼容ECG采集系统，该系统使用10个MRI兼容电极定位在标准躯干位置，同轴电缆传输线将ECG信号从电极传输到MRI 公共卫生相关性：本研究具有相关性，因为在对重症和危重患者（如创伤或缺血性患者）进行MRI扫描期间难以记录准确的ECG，这导致其被排除在成像之外。然而，MRI是检测急性卒中1、急性脊髓损伤2和梗死后损伤3的一种极佳方式，因此改善ECG将改善护理。此外，12导联ECG是检测急性缺血的标准护理4，但缺血指标经常被MRI掩盖

DESCRIPTION (provided by applicant): This SBIR project aims to develop an MRI-compatible 12-lead ECG system. Such a system will provide greatly improved physiological monitoring inside the MRI, which is important for imaging severely ill patients (stroke, spine, patients with ischemic histories), and is also key to future MRI-guided interventions and surgeries. Current MRI-compatible ECG monitoring is limited to 4-closely spaced electrodes, and is intended mainly for outpatient imaging. In addition, gradient-induction (VGrad) and magneto-hydro-dynamic (VMHD) artifacts distort the waveform, not allowing for reliable acute-ischemia detection. The 12-lead system will remove these artifacts and provide clean ECG (ECGreal) traces, similar to those measured outside MRI. Our Specific Aims are: Aim #1: MR compatible 12-lead ECG acquisition and transmission We will develop a 3 Tesla MR-compatible ECG acquisition system using 10 MRI-compatible electrodes positioned at standard torso locations, with coaxial-cable transmission lines carrying ECG signals from the electrodes to the MRI PUBLIC HEALTH RELEVANCE: This study is relevant due to difficulties in recording accurate ECGs during MRI scanning of severely ill and critical care patients, such as trauma or ischemic patients, which leads to their exclusion from imaging. However, MRI is an excellent modality to detect acute stroke1, acute spinal injury2, and post- infarction damage3, so improved ECG would lead to improved care. Moreover, 12-lead ECG is the standard-of-care for detecting acute ischemia4, but ischemia indicators frequently are masked by MRI