12-lead MRI-Compatible ECG for physiological monitoring and scanner synchronizati

描述（由申请人提供）：本SBIR项目旨在开发一种mri兼容的12导联心电系统。该系统将大大改善MRI内部的生理监测，这对重症患者（中风、脊柱、有缺血性病史的患者）的成像非常重要，也是未来MRI引导干预和手术的关键。目前与mri兼容的心电图监测仅限于4个紧密间隔的电极，主要用于门诊成像。此外，梯度感应（VGrad）和磁流体动力学（VMHD）伪像会扭曲波形，无法进行可靠的急性缺血检测。12导联系统将消除这些伪影，并提供干净的ECG （ECGreal）痕迹，类似于在MRI外测量的痕迹。我们将开发一个3特斯拉的MR兼容ECG采集系统，该系统使用10个位于标准躯干位置的MRI兼容电极，同轴电缆传输线将ECG信号从电极传输到MRI

DESCRIPTION (provided by applicant): This SBIR project aims to develop an MRI-compatible 12-lead ECG system. Such a system will provide greatly improved physiological monitoring inside the MRI, which is important for imaging severely ill patients (stroke, spine, patients with ischemic histories), and is also key to future MRI-guided interventions and surgeries. Current MRI-compatible ECG monitoring is limited to 4-closely spaced electrodes, and is intended mainly for outpatient imaging. In addition, gradient-induction (VGrad) and magneto-hydro-dynamic (VMHD) artifacts distort the waveform, not allowing for reliable acute-ischemia detection. The 12-lead system will remove these artifacts and provide clean ECG (ECGreal) traces, similar to those measured outside MRI. Our Specific Aims are: Aim #1: MR compatible 12-lead ECG acquisition and transmission We will develop a 3 Tesla MR-compatible ECG acquisition system using 10 MRI-compatible electrodes positioned at standard torso locations, with coaxial-cable transmission lines carrying ECG signals from the electrodes to the MRI PUBLIC HEALTH RELEVANCE: This study is relevant due to difficulties in recording accurate ECGs during MRI scanning of severely ill and critical care patients, such as trauma or ischemic patients, which leads to their exclusion from imaging. However, MRI is an excellent modality to detect acute stroke1, acute spinal injury2, and post- infarction damage3, so improved ECG would lead to improved care. Moreover, 12-lead ECG is the standard-of-care for detecting acute ischemia4, but ischemia indicators frequently are masked by MRI