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High throughput assays to detect inhibition of a key M. tuberculosis protease

High throughput assays to detect inhibition of a key M. tuberculosis protease
高通量测定检测关键结核分枝杆菌蛋白酶的抑制
批准号：
8321716
负责人：
Tanya Parish
金额：
$39.58万
依托单位：
ACCESS TO ADVANCED HEALTH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-09-01 至 2013-07-15
来源：
https://reporter.nih.gov/project-details/8321716
关键词：
Anti-Bacterial AgentsAutomobile DrivingBacteriaBacterial InfectionsBiochemicalBiologicalBiological AssayBiologyCause of DeathCell physiologyCellsChemicalsCommunicable DiseasesCritical PathwaysDiseaseDrug resistanceEnvironmentEvaluationGatekeepingGeneticGrowthHousingHumanIn VitroInfectionKineticsLaboratoriesLeadLibrariesMeasuresMetabolic PathwayMulti-Drug ResistanceMycobacterium tuberculosisNatural regenerationOrganismOutcomePathogenicityPeptide HydrolasesPeptidesPharmaceutical PreparationsPhysiologicalPhysiologyPlayProcessProtein SecretionProteinsReadingResistanceRoleRunningScreening procedureTestingTherapeuticTherapeutic AgentsTuberculosisUnited States National Institutes of HealthVirulenceWorkassay developmentbasecombatdrug developmentdrug discoverydrugged drivinghigh throughput screeningimprovedinhibitor/antagonistinnovationinsightinterestkillingslatent infectionmeetingsnovel therapeuticsoverexpressionpathogenresponsesignal peptidasesmall moleculestressortool

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期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents.
DOI： 10.1002/open.201500001
发表时间： 2015-06
期刊： ChemistryOpen
影响因子： 2.3
作者： [Russo F, Gising J, Åkerbladh L, Roos AK, Naworyta A, Mowbray SL, Sokolowski A, Henderson I, Alling T, Bailey MA, Files M, Parish T, Karlén A, Larhed M]
通讯作者： Larhed M
A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.
DOI： 10.1021/acsinfecdis.6b00075
发表时间： 2016-12-09
期刊： ACS INFECTIOUS DISEASES
影响因子： 5.3
作者： [Bonnett, Shilah A., Ollinger, Juliane, Chandrasekera, Susantha, Florio, Stephanie, O'Malley, Theresa, Files, Megan, Jee, Jo-Ann, Ahn, James, Casey, Allen, Ovechkina, Yulia, Roberts, David, Korkegian, Aaron, Parish, Tanya]
通讯作者： Parish, Tanya
Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis.
DOI： 10.1128/spectrum.04974-22
发表时间： 2023-02-14
期刊： Microbiology spectrum
影响因子： 3.7
作者： []
通讯作者：
Developing triazolopyrimidines as novel anti-tubercular agents
  • 批准号：
    10672660
  • 项目类别：
  • 资助金额：
    $49.23万
  • 财政年份：
    2022
  • 负责人：
    Tanya Parish
  • 依托单位：
    SEATTLE CHILDREN'S HOSPITAL
High content, high throughput, diversity screen for novel anti-tubercular agents targeting intracellular bacteria
  • 批准号：
    10526217
  • 项目类别：
  • 资助金额：
    $29.54万
  • 财政年份：
    2022
  • 负责人：
    Tanya Parish
  • 依托单位：
    SEATTLE CHILDREN'S HOSPITAL
Basic Science Core
  • 批准号：
    10595077
  • 项目类别：
  • 资助金额：
    $14.4万
  • 财政年份：
    2022
  • 负责人：
    Tanya Parish
  • 依托单位：
    UNIVERSITY OF WASHINGTON
High content, high throughput, diversity screen for novel anti-tubercular agents targeting intracellular bacteria
  • 批准号：
    10621242
  • 项目类别：
  • 资助金额：
    $24.61万
  • 财政年份：
    2022
  • 负责人：
    Tanya Parish
  • 依托单位：
    SEATTLE CHILDREN'S HOSPITAL
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