Basic Science Core

项目概要（基础科学核心） 开发新的药物、疫苗和诊断方法来抗击结核病流行需要增加 了解结核分枝杆菌的发病机制。实现这些目标将需要新的 接受过基本和先进结核病方法培训的调查人员，以及能够使用高度专业化的设施， 设备.基础科学核心的主要目标是提供必要的咨询和培训， 使调查人员具备推进实地工作所需的专门知识和工具。基础科学核心将集中在 新的研究人员（NI）在他们的职业生涯开始时，以及更多的结核病新科学家 research.我们将利用西雅图内优秀的结核病研究设施和设备， 华盛顿大学、西雅图儿童中心的SEA-TRAC调查人员的补充专业知识 研究所和弗雷德哈钦森癌症研究中心。 在目标1中，我们将为寻求进入BSL 3的新调查人员提供基本培训，以启动新的 结核病研究项目。我们的课程将分为：第1层-基本的BSL 3工作与专门的BSL 3教练; 第二层--针对微生物学或免疫学工作的实践性专业培训。在Aim中 2.我们将为有兴趣研究结核病微生物学的新结核病研究者提供咨询服务。 我们将建议最适合的方法和技术，以解决其特定的病原体相关的 研究问题。利用西雅图结核病研究界的广泛专业知识和资源， 与发展核心试点计划合作，我们还将提供深入培训的机会， 多种标准和先进的方法来研究结核病生物学。在目标3中，我们将开发一个平行的 该计划的一个目标2，为新的结核病研究人员与结核病免疫学的兴趣。核心提供 咨询服务，以匹配最适合的先进方法，以解决结核病免疫学研究 问题.我们还将提供广泛的尖端技术的深入培训， 了解宿主对Mtb的反应。总之，这些努力将使下一代结核病 研究人员具有产生科学见解和帮助结束结核病流行的技能。

PROJECT SUMMARY (BASIC SCIENCE CORE) Developing new drugs, vaccines, and diagnostics to combat the TB epidemic requires increased understanding of Mycobacterium tuberculosis pathogenesis. Achieving these goals will require an influx of new investigators trained in basic and advanced TB methods, as well as access to highly specialized facilities and equipment. The primary goal of the Basic Science Core is to provide the consultation and training necessary to equip investigators with the expertise and tools needed to advance the field. The Basic Science Core will focus on new investigators (NIs) at the start of their careers and more established scientists who are new to TB research. We will utilize the outstanding TB research facilities and equipment within Seattle, and leverage the complementary expertise of SEA-TRAC investigators at the University of Washington, Seattle Children’s Research Institute, and the Fred Hutchinson Cancer Research Center. In Aim 1, we will provide basic training to new investigators who seek access to the BSL3 to initiate new TB research programs. Our curriculum will be split into: Tier 1 -- basic BSL3 work with a dedicated BSL3 trainer; and Tier 2 -- hands-on, specialized training for either microbiology-focused or immunology-focused work. In Aim 2, we will provide a consultation service for new TB investigators with an interest in studying Mtb microbiology. We will advise regarding the best-suited approaches and technologies to address their specific pathogen-related research questions. Drawing from the broad expertise and resources of the Seattle TB research community, and working with the Development Core Pilot Program, we will also provide opportunities for in-depth training in a diverse suite of standard and advanced approaches to study Mtb biology. In Aim 3, we will develop a parallel program to the one in Aim 2, for new TB investigators with an interest in Mtb immunology. We will provide a consultation service to match the best-suited advanced approaches to address Mtb immunology research questions. We will also provide in-depth training in a broad range of cutting-edge technologies that target understanding the host response to Mtb. Altogether, these efforts will equip the next generation of TB investigators with the skills to generate scientific insights and help end the TB epidemic.