Basic Science Core

项目总结(基础科学核心) 开发抗击结核病流行的新药、疫苗和诊断方法需要增加 对结核分枝杆菌发病机制的认识。实现这些目标将需要大量新的 接受过基本和高级结核病方法培训的调查人员，以及获得高度专业化的设施和 设备。基础科学核心的主要目标是提供必要的咨询和培训 为调查人员配备推进该领域所需的专业知识和工具。基础科学核心将集中于 关于职业生涯开始的新研究人员(NIS)和更多对结核病陌生的老牌科学家 研究。我们将利用西雅图优秀的结核病研究设施和设备，并利用 华盛顿大学西雅图儿童学院SEA-TRAC调查人员的互补专业知识 以及弗雷德·哈钦森癌症研究中心。 在目标1中，我们将为寻求进入BSL3开展新工作的新调查员提供基本培训 结核病研究项目。我们的课程将分为：第一级--基础BSL3与专门的BSL3培训师一起工作； 和第二级--针对侧重微生物学或免疫学的工作的实际操作和专门培训。在AIM 2、我们将为有兴趣研究结核分枝杆菌微生物学的新结核病研究人员提供咨询服务。 我们将就解决特定病原体相关问题的最佳方法和技术提出建议。 研究问题。来自西雅图结核病研究社区的广泛专业知识和资源，以及 与开发核心试点计划合作，我们还将提供深入培训的机会 研究结核分枝杆菌生物学的各种标准和高级方法。在目标3中，我们将开发一个并行的 为对结核分枝杆菌免疫学感兴趣的新结核病研究人员提供AIM 2中的计划。我们将提供一个 提供咨询服务，以匹配最适合的先进方法来解决结核分枝杆菌免疫学研究 问题。我们还将提供针对以下目标的广泛尖端技术的深入培训 了解宿主对结核分枝杆菌的反应。总之，这些努力将为下一代结核病提供装备 具有产生科学见解和帮助结束结核病流行的技能的调查人员。

PROJECT SUMMARY (BASIC SCIENCE CORE) Developing new drugs, vaccines, and diagnostics to combat the TB epidemic requires increased understanding of Mycobacterium tuberculosis pathogenesis. Achieving these goals will require an influx of new investigators trained in basic and advanced TB methods, as well as access to highly specialized facilities and equipment. The primary goal of the Basic Science Core is to provide the consultation and training necessary to equip investigators with the expertise and tools needed to advance the field. The Basic Science Core will focus on new investigators (NIs) at the start of their careers and more established scientists who are new to TB research. We will utilize the outstanding TB research facilities and equipment within Seattle, and leverage the complementary expertise of SEA-TRAC investigators at the University of Washington, Seattle Children’s Research Institute, and the Fred Hutchinson Cancer Research Center. In Aim 1, we will provide basic training to new investigators who seek access to the BSL3 to initiate new TB research programs. Our curriculum will be split into: Tier 1 -- basic BSL3 work with a dedicated BSL3 trainer; and Tier 2 -- hands-on, specialized training for either microbiology-focused or immunology-focused work. In Aim 2, we will provide a consultation service for new TB investigators with an interest in studying Mtb microbiology. We will advise regarding the best-suited approaches and technologies to address their specific pathogen-related research questions. Drawing from the broad expertise and resources of the Seattle TB research community, and working with the Development Core Pilot Program, we will also provide opportunities for in-depth training in a diverse suite of standard and advanced approaches to study Mtb biology. In Aim 3, we will develop a parallel program to the one in Aim 2, for new TB investigators with an interest in Mtb immunology. We will provide a consultation service to match the best-suited advanced approaches to address Mtb immunology research questions. We will also provide in-depth training in a broad range of cutting-edge technologies that target understanding the host response to Mtb. Altogether, these efforts will equip the next generation of TB investigators with the skills to generate scientific insights and help end the TB epidemic.