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Silencing of Th17 cell differentiation by IRF8 in the development of colitis

Silencing of Th17 cell differentiation by IRF8 in the development of colitis
IRF8 在结肠炎发展过程中沉默 Th17 细胞分化
批准号：
8305224
负责人：
HUABAO XIONG
金额：
$42.38万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-09-01 至 2012-12-31
来源：
https://reporter.nih.gov/project-details/8305224
关键词：
Autoimmune ProcessAutomobile DrivingBindingBinding SitesCD4 Positive T LymphocytesCell Culture TechniquesCell Differentiation processCell LineageCell NucleusCellsChromosome StructuresChronicColitisConfocal MicroscopyControl GroupsCrohn&aposs diseaseDendritic CellsDevelopmentDigestive System DisordersDiseaseDoseEnzyme-Linked Immunosorbent AssayFamilyFeedbackGastrointestinal tract structureGene ActivationGene ExpressionGenerationsGenetic ProgrammingGenetic TranscriptionGoalsHelper-Inducer T-LymphocyteHumanIFN consensus sequence binding proteinIRF4 geneImmune responseIn VitroInfiltrationInflammationInflammatoryInflammatory Bowel DiseasesInterferon Type IIInterferonsInterleukin-10Interleukin-12Interleukin-17Interleukin-4Interleukin-6Knockout MiceLightLocationMediatingMolecularMusNuclear Orphan ReceptorPathogenesisPathologicPlayProductionProteinsRegulationRelative (related person)ReportingResearchRoleSTAT3 geneT-LymphocyteT-Lymphocyte SubsetsTh1 CellsTh2 CellsTransfectioncytokineinhibitor/antagonistinsightinterleukin-22interleukin-23macrophagemembernoveloverexpressionprogramspromoterreceptorreconstitutionresearch studyresponseretroviral transductiontherapeutic targettranscription factor

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