Silencing of Th17 cell differentiation by IRF8 in the development of colitis

IRF8 在结肠炎发展过程中沉默 Th17 细胞分化

• 批准号: 8305224
• 负责人: HUABAO XIONG
• 金额: $ 42.38万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305224
• 关键词: Autoimmune Process; Automobile Driving; Binding; Binding Sites; CD4 Positive T Lymphocytes; Cell Culture Techniques; Cell Differentiation process; Cell Lineage; Cell Nucleus; Cells; Chromosome Structures; Chronic; Colitis; Confocal Microscopy; Control Groups; Crohn' s disease; Dendritic Cells; Development; Digestive System Disorders; Disease; Dose; Enzyme-Linked Immunosorbent Assay; Family; Feedback; Gastrointestinal tract structure; Gene Activation; Gene Expression; Generations; Genetic Programming; Genetic Transcription; Goals; Helper-Inducer T-Lymphocyte; Human; IFN consensus sequence binding protein; IRF4 gene; Immune response; In Vitro; Infiltration; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Interferon Type II; Interferons; Interleukin-10; Interleukin-12; Interleukin-17; Interleukin-4; Interleukin-6; Knockout Mice; Light; Location; Mediating; Molecular; Mus; Nuclear Orphan Receptor; Pathogenesis; Pathologic; Play; Production; Proteins; Regulation; Relative (related person); Reporting; Research; Role; STAT3 gene; T-Lymphocyte; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells; Transfection; cytokine; inhibitor/antagonist; insight; interleukin-22; interleukin-23; macrophage; member; novel; overexpression; programs; promoter; receptor; reconstitution; research study; response; retroviral transduction; therapeutic target; transcription factor