TIM-3: Galectin-9: A Novel Regulatory Pathway of Alloimmune Activation

TIM-3：Galectin-9：同种免疫激活的新型调控途径

• 批准号: 8312994
• 负责人: NADER NAJAFIAN
• 金额: $ 31.2万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8312994
• 关键词: Acute; Adoptive Transfer; Affect; Alloantigen; Allograft Tolerance; Allografting; Anti-Inflammatory Agents; Anti-inflammatory; Antibodies; Antibody Formation; Antigen Presentation; Antigens; Apoptosis; Apoptotic; Area; Ascaridil; B cell differentiation; B-Lymphocytes; Behavior; Binding; CD28 gene; CD4 Positive T Lymphocytes; CTLA4-Ig; Cardiac; Cell Death; Cell Differentiation process; Cell model; Cell physiology; Cells; Chronic; Clinical Protocols; Collaborations; Commit; Data; Development; Endothelial Cells; Equilibrium; Frequencies; Functional disorder; Galactose Binding Lectin; Galectin 3; Generations; Goals; Helper-Inducer T-Lymphocyte; Human; Immune; Immunity; Immunosuppression; In Vitro; Inflammatory Response; Interleukin-6; Investigation; Laboratories; Life; Ligands; MHC antigen; Maintenance; Mediating; Memory; Modeling; Molecular; Molecular Mechanisms of Action; Morbidity - disease rate; Mus; Myocardial; Natural Immunity; Nature; Necrosis; Organ; Organ Transplantation; Pathway interactions; Patients; Phenotype; Play; Procedures; Production; Publishing; Recombinants; Regulation; Regulatory Pathway; Regulatory T-Lymphocyte; Research; Resistance; Role; Signal Transduction; Solid; Surface; T cell differentiation; T cell response; T memory cell; T-Lymphocyte; Testing; Transgenic Animals; Translating; Transplantation; Virus Diseases; activating transcription factor 3; adaptive immunity; allograft rejection; anergy; base; clinically significant; cytokine; end-stage organ failure; exhaustion; heart allograft; improved; in vivo; isoimmunity; memory recall; mouse model; novel; novel strategies; prevent; receptor; research study; response; tool; transcription factor

项目成果

The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.

• DOI: 10.1111/j.1600-6143.2012.04180.x
• 发表时间: 2012-10
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• 作者: Magee CN;Boenisch O;Najafian N
• 通讯作者: Najafian N