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TIM-3: Galectin-9: A Novel Regulatory Pathway of Alloimmune Activation

TIM-3: Galectin-9: A Novel Regulatory Pathway of Alloimmune Activation
TIM-3：Galectin-9：同种免疫激活的新型调控途径
批准号：
8312994
负责人：
NADER NAJAFIAN
金额：
$31.2万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-08-15 至 2012-07-31
来源：
https://reporter.nih.gov/project-details/8312994
关键词：
AcuteAdoptive TransferAffectAlloantigenAllograft ToleranceAllograftingAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesAntibody FormationAntigen PresentationAntigensApoptosisApoptoticAreaAscaridilB cell differentiationB-LymphocytesBehaviorBindingCD28 geneCD4 Positive T LymphocytesCTLA4-IgCardiacCell DeathCell Differentiation processCell modelCell physiologyCellsChronicClinical ProtocolsCollaborationsCommitDataDevelopmentEndothelial CellsEquilibriumFrequenciesFunctional disorderGalactose Binding LectinGalectin 3GenerationsGoalsHelper-Inducer T-LymphocyteHumanImmuneImmunityImmunosuppressionIn VitroInflammatory ResponseInterleukin-6InvestigationLaboratoriesLifeLigandsMHC antigenMaintenanceMediatingMemoryModelingMolecularMolecular Mechanisms of ActionMorbidity - disease rateMusMyocardialNatural ImmunityNatureNecrosisOrganOrgan TransplantationPathway interactionsPatientsPhenotypePlayProceduresProductionPublishingRecombinantsRegulationRegulatory PathwayRegulatory T-LymphocyteResearchResistanceRoleSignal TransductionSolidSurfaceT cell differentiationT cell responseT memory cellT-LymphocyteTestingTransgenic AnimalsTranslatingTransplantationVirus Diseasesactivating transcription factor 3adaptive immunityallograft rejectionanergybaseclinically significantcytokineend-stage organ failureexhaustionheart allograftimprovedin vivoisoimmunitymemory recallmouse modelnovelnovel strategiespreventreceptorresearch studyresponsetooltranscription factor

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期刊论文(1)
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会议论文
The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.
DOI： 10.1111/j.1600-6143.2012.04180.x
发表时间： 2012-10
期刊： American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子： --
作者： [Magee CN, Boenisch O, Najafian N]
通讯作者： Najafian N
TIM molecules and the innate: adaptive interface in alloimmunity
  • 批准号：
    8707632
  • 项目类别：
  • 资助金额：
    $31.24万
  • 财政年份：
    2013
  • 负责人：
    NADER NAJAFIAN
  • 依托单位：
    BRIGHAM AND WOMEN'S HOSPITAL
Negative Costimulatory Pathways in Rejection & Tolerance
  • 批准号：
    7433308
  • 项目类别：
  • 资助金额：
    $11.97万
  • 财政年份：
    2007
  • 负责人：
    NADER NAJAFIAN
  • 依托单位：
    BRIGHAM AND WOMEN'S HOSPITAL
Negative Costimulatory Pathways in Rejection & Tolerance
  • 批准号：
    7263396
  • 项目类别：
  • 资助金额：
    $11.91万
  • 财政年份：
    2007
  • 负责人：
    NADER NAJAFIAN
  • 依托单位：
    BRIGHAM AND WOMEN'S HOSPITAL
Negative Costimulatory Pathways in Rejection & Tolerance
  • 批准号：
    7629565
  • 项目类别：
  • 资助金额：
    $12.97万
  • 财政年份：
    2007
  • 负责人：
    NADER NAJAFIAN
  • 依托单位：
    BRIGHAM AND WOMEN'S HOSPITAL
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