Searching for Genetic Modifiers of TDP-43 Proteinopathy Using an Animal Model

使用动物模型寻找 TDP-43 蛋白病的遗传修饰剂

• 批准号: 8270429
• 负责人: JANE Y WU
• 金额: $ 37.52万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8270429
• 关键词: Affect; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Animal Model; Binding; Biochemical; Biological Assay; Biological Models; Biological Process; Cell Culture Techniques; Cell Line; Cell physiology; Cells; Clinical; Clinical Pathology; DNA-Binding Proteins; Dementia; Disease; Drosophila genus; Exhibits; Frontotemporal Lobar Degenerations; Future; Gene Mutation; Gene-Modified; Genes; Genetic; Goals; Heterogeneity; Human; In Vitro; Modeling; Molecular; Motor Neuron Disease; Mutation; Neurodegenerative Disorders; Neurons; Outcome; Pathogenesis; Pathology; Patients; Phosphorylation; Post-Transcriptional RNA Processing; Proteins; Publishing; RNA; RNA-Binding Proteins; Role; Sampling; Signal Pathway; Testing; Tissues; Transgenic Model; Transgenic Organisms; Work; base; fly; in vivo; mutant; neuronal survival; neuropathology; protein TDP-43; protein complex; relating to nervous system; research study; therapeutic target

项目成果

AxonQuant: A Microfluidic Chamber Culture-Coupled Algorithm That Allows High-Throughput Quantification of Axonal Damage.

AxonQuant：一种微流控室培养耦合算法，可对轴突损伤进行高通量定量

• DOI: 10.1159/000358092
• 发表时间: 2014
• 期刊: Neuro-Signals
• 作者: Li Y;Yang M;Huang Z;Chen X;Maloney MT;Zhu L;Liu J;Yang Y;Du S;Jiang X;Wu JY
• 通讯作者: Wu JY

Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation.

精神分裂症中 Dysbindin-1B 亚型表达增加及其形成攻击体的倾向

• DOI: 10.1038/celldisc.2015.32
• 发表时间: 2015
• 期刊: Cell discovery
• 影响因子: 33.5
• 作者: Xu Y;Sun Y;Ye H;Zhu L;Liu J;Wu X;Wang L;He T;Shen Y;Wu JY;Xu Q
• 通讯作者: Xu Q

Characterization of β-domains in C-terminal fragments of TDP-43 by scanning tunneling microscopy.

通过扫描隧道显微镜的TDP-43 C末端片段中β-域的表征。

• DOI: 10.1016/j.jsb.2012.10.011
• 发表时间: 2013-01
• 期刊: JOURNAL OF STRUCTURAL BIOLOGY
• 影响因子: 3
• 作者: Xu, Meng;Zhu, Li;Liu, Jianghong;Yang, Yanlian;Wu, Jane Y.;Wang, Chen
• 通讯作者: Wang, Chen

AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth.

• DOI: 10.1007/s13238-012-2126-2
• 发表时间: 2013-02
• 期刊: PROTEIN & CELL
• 影响因子: 21.1
• 作者: Zhu, Kun;Chen, Xiaoping;Liu, Jianghong;Ye, Haihong;Zhu, Li;Wu, Jane Y.
• 通讯作者: Wu, Jane Y.