Transcriptional mechanisms that contribute to HIV-1 latency

导致 HIV-1 潜伏期的转录机制

• 批准号: 8299328
• 负责人: Andrew J Henderson
• 金额: $ 43.26万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8299328
• 关键词: Anti-Retroviral Agents; Architecture; Biochemical; Biochemical Process; Cell Line; Cells; Chromatin; Complex; Coupled; Data; Event; Exhibits; Genes; Genetic Transcription; Goals; HIV; HIV Infections; HIV-1; In Vitro; Infection; Interruption; Libraries; Life; Long Terminal Repeats; Maintenance; Mass Spectrum Analysis; Molecular; Play; Positive Transcriptional Elongation Factor B; Properdin; Proteomics; Proviruses; RNA Polymerase II; Recruitment Activity; Regulation; Repression; Role; Source; System; T memory cell; T-Lymphocyte; Tissues; Transcription Elongation; Transcription Initiation; Transcription Repressor/Corepressor; Viral Proteins; Virus; cellular targeting; chromatin immunoprecipitation; chromatin remodeling; gene repression; insight; macrophage; negative elongation factor; novel; premature; promoter; purge; success; termination factor; transcription termination

项目成果

Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency.

• DOI: 10.1155/2012/614120
• 发表时间: 2012
• 期刊: Molecular biology international
• 作者: Schiralli Lester GM;Henderson AJ
• 通讯作者: Henderson AJ

T Cell Transcription Factors and Their Impact on HIV Expression.

T 细胞转录因子及其对 HIV 表达的影响。

• DOI: 10.4137/vrt.s12147
• 发表时间: 2013
• 期刊: Virology : research and treatment
• 作者: Kaczmarek,Katarzyna;Morales,Ayana;Henderson,AndrewJ
• 通讯作者: Henderson,AndrewJ

Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells.

• DOI: 10.4049/jimmunol.1402581
• 发表时间: 2015-04-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Kaczmarek Michaels K;Natarajan M;Euler Z;Alter G;Viglianti G;Henderson AJ
• 通讯作者: Henderson AJ