Molecular mechanisms of Shiga toxin action in the mammal central nervous system

志贺毒素在哺乳动物中枢神经系统中作用的分子机制

• 批准号: 8288961
• 负责人: Fumiko Obata
• 金额: $ 37.5万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-05 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8288961
• 关键词: Actins; Astrocytes; Brain; Calcium; Cell Culture Techniques; Cells; Central Nervous System Diseases; Cessation of life; Coculture Techniques; Coma; Conscious; Cortical Blindness; Data; Demyelinations; Diarrhea; Disease; Disease model; Electrons; Escherichia coli EHEC; Escherichia coli Infections; Excitatory Amino Acid Antagonists; Food Poisoning; Glutamate Transporter; Glutamates; Goals; Hemolytic-Uremic Syndrome; Hindlimb; Image; Impairment; In Vitro; Life; MARCKS gene; Mammals; Mediating; Microscopic; Modeling; Molecular; Motor; Mus; Nervous System Physiology; Neuraxis; Neurons; Outcome; Paralysed; Patients; Phosphorylation; Postsynaptic Membrane; Presynaptic Terminals; Prevention; Process; Publishing; Research; Research Personnel; Seizures; Shiga Toxin; Shiga-Like Toxin I; Shiga-Like Toxin II; Signal Transduction; Slice; Staging; Symptoms; Synapses; Systems Analysis; Testing; Therapeutic; Therapeutic Agents; Toxic effect; Vegetables; Work; base; beef; disability; globotriaosylceramide; in vivo; mortality; mouse model; neurotransmission; presynaptic; prevent; response; therapeutic target