Robust Genetic Switches for Mycobacteria

分枝杆菌的强大遗传开关

• 批准号: 8270646
• 负责人: Dirk Schnappinger
• 金额: $ 56.19万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8270646
• 关键词: ATP Synthesis Pathway; Acquired Immunodeficiency Syndrome; Agar; Anabolism; Antibiotics; Attenuated; Awareness; Biological Assay; Biotin; Carbon; Catabolism; Cause of Death; Cells; Cessation of life; Collaborations; Communicable Diseases; Complement; Couples; Cycloserine; Cytochrome c Reductase; Development; Disease; Drug Delivery Systems; Drug Resistant Tuberculosis; Drug resistance; Drug resistance in tuberculosis; Electron Transport; Essential Genes; Fatty Acids; Gene Expression; Gene Silencing; Gene Targeting; Generations; Genes; Genetic; Genetic Transcription; Genus Mycobacterium; Goals; Growth; Growth Inhibitors; Health; Human; Immunization; In Vitro; Individual; Infection; Infectious Agent; Lead; Measures; Metabolism; Mus; Mycobacterium smegmatis; Mycobacterium tuberculosis; NADH; NADH dehydrogenase (ubiquinone); Patients; Pharmaceutical Preparations; Population; Predisposition; Proteins; Proton-Motive Force; Protons; Quinolones; Recording of previous events; Reporter Genes; Respiration; Respiratory Chain; Rifampin; Role; Source; System; Tuberculosis; Validation; Vitamin K 2; Volatile Fatty Acids; Work; antimicrobial; base; chemotherapy; drug development; functional genomics; genetic regulatory protein; global health; improved; inhibitor/antagonist; isoniazid; killings; metabolomics; mutant; oxidation; premature; prevent; programs; protein degradation; research and development; research study; resistant strain; respiratory; respiratory enzyme; social; success; tool; transcriptomics; tuberculosis drugs