Project 2. Acquisition, synthesis and importance of biotin in Mtb.

项目 2. 结核分枝杆菌中生物素的获取、合成及其重要性。

基本信息

  • 批准号:
    10426180
  • 负责人:
  • 金额:
    $ 29.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-06-12 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Project 2, Abstract Biotin is a universally essential cofactor for enzymes that perform various carboxylation, decarboxylation, and transcarboxylation reactions. This includes key enzymes in fatty acid biosynthesis, replenishment of metabolites in the tricarboxylic acid cycle, and amino acid metabolism. When available, Mycobacterium tuberculosis (Mtb) can utilize exogenous biotin but Mtb is unable to scavenge biotin from the host. To grow and survive in the host Mtb thus needs to synthesize biotin. Mtb enzymes involved in synthesizing biotin, ligating biotin, or utilizing biotin have been identified by this group and others as attractive drug targets because their inhibition has the potential to shorten TB chemotherapy. However, a better understanding of the biology of biotin in Mtb is required to fully and effectively exploit Mtb’s susceptibility to biotin starvation for drug development. This Project addresses this need by (i) identifying and functionally classifying the genes Mtb requires to synthesize and utilize biotin, (ii) defining activities Mtb requires to import biotin or recycle biotin, and (iii) determining how biotin starvation affects Mtb’s response to host relevant stresses. These activities directly contribute to the overall program goal of understanding key pathways in Mtb biology that are important in adaptation to disease-relevant stressors.
项目2,摘要

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Dirk Schnappinger其他文献

Dirk Schnappinger的其他文献

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{{ truncateString('Dirk Schnappinger', 18)}}的其他基金

2023 Tuberculosis Drug Discovery and Development Gordon Research Conference and Gordon Research Seminar
2023结核病药物发现与开发戈登研究大会暨戈登研究研讨会
  • 批准号:
    10675238
  • 财政年份:
    2023
  • 资助金额:
    $ 29.28万
  • 项目类别:
Project 2. Acquisition, synthesis and importance of biotin in Mtb.
项目 2. 结核分枝杆菌中生物素的获取、合成及其重要性。
  • 批准号:
    10190814
  • 财政年份:
    2020
  • 资助金额:
    $ 29.28万
  • 项目类别:
Project 2. Acquisition, synthesis and importance of biotin in Mtb.
项目 2. 结核分枝杆菌中生物素的获取、合成及其重要性。
  • 批准号:
    10641879
  • 财政年份:
    2020
  • 资助金额:
    $ 29.28万
  • 项目类别:
Robust Genetic Switches for Mycobacteria
分枝杆菌的强大遗传开关
  • 批准号:
    8270646
  • 财政年份:
    2011
  • 资助金额:
    $ 29.28万
  • 项目类别:
Biotin synthesis and biotin ligation in Mtb
Mtb 中的生物素合成和生物素连接
  • 批准号:
    8023571
  • 财政年份:
    2010
  • 资助金额:
    $ 29.28万
  • 项目类别:
Biotin synthesis and biotin ligation in Mtb
Mtb 中的生物素合成和生物素连接
  • 批准号:
    8204466
  • 财政年份:
    2010
  • 资助金额:
    $ 29.28万
  • 项目类别:
Biotin synthesis and biotin ligation in Mtb
Mtb 中的生物素合成和生物素连接
  • 批准号:
    8414837
  • 财政年份:
    2010
  • 资助金额:
    $ 29.28万
  • 项目类别:
Biotin synthesis and biotin ligation in Mtb
Mtb 中的生物素合成和生物素连接
  • 批准号:
    8586248
  • 财政年份:
    2010
  • 资助金额:
    $ 29.28万
  • 项目类别:
Alternative Respiratory Chains of M. tuberculosis
结核分枝杆菌的替代呼吸链
  • 批准号:
    7187436
  • 财政年份:
    2004
  • 资助金额:
    $ 29.28万
  • 项目类别:
Alternative Respiratory Chains of M. tuberculosis
结核分枝杆菌的替代呼吸链
  • 批准号:
    6846083
  • 财政年份:
    2004
  • 资助金额:
    $ 29.28万
  • 项目类别:

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