UW-Madison Small Animal PET: High Resolution Large Bore Tomograph

描述(申请人提供)：正电子发射断层扫描(PET)用于体内纵向研究潜在的治疗方法在动物模型中的人类疾病。此外，小动物PET还可以研究基本的生物过程，这是其他成像方式不可能做到的。随着高分辨率专用小动物扫描仪的出现，该领域在过去几年中迅速增长。小动物PET已经在威斯康星大学麦迪逊分校的各种研究中得到了应用。威斯康星州哈洛生物心理学中心、威康辛国家灵长类动物研究中心和医学与公共卫生学院是猕猴群体的家园，20世纪90年代初在麦迪逊用ECAT 931人体扫描仪进行的恒河猴脑PET研究是文献中最早的研究之一。2002年8月，UW收购了一台microPET P4，该设备已被用于获取1859次动物扫描，其中包括1515次恒河猴脑扫描(截至2009年12月31日)。为西门子医疗解决方案美国公司(诺克斯维尔，田纳西州)制造的微型PET Focus 220小型动物正电子发射断层扫描(PET)扫描仪申请资金。Focus 220提供了更高的空间分辨率(1.4 mm半高宽)和灵敏度(4%)以及大视场(横轴19厘米，轴向7.6厘米)。这使得能够在减少示踪质量的情况下对猕猴大脑进行更详细的成像，以及同时对多只大鼠或小鼠进行成像。在这次重新提交中，我们注意到所要求的仪器对于确保继续进行NIH资助的研究的能力至关重要。供应商西门子于2009年7月发出正式通知，由于缺乏更换组件，P4的支持日期将于2010年7月1日结束。这增加了在不久的将来失去对现有工具的使用的可能性。 与公共卫生相关：要求提供资金用于小动物正电子发射断层扫描(PET)扫描仪，以取代现有设备。该设备将用于人体病理动物模型的纵向活体研究和基本生物过程的成像。这将使UWMadison PET成像计划继续适应越来越多的病理研究，如情绪障碍、胎儿酒精暴露、多发性硬化症和帕金森氏症。

DESCRIPTION (provided by applicant): Positron emission tomography (PET) is used for in vivo longitudinal studies of potential therapies in animal models of human disease. Small animal PET moreover permits studies of fundamental biological processes that are not possible with other imaging modalities. With the advent of high resolution dedicated small animal scanners the field has grown rapidly in the last few years. Small animal PET has been used in a wide variety of studies at UW-Madison. UW is home to macaque colonies at the Harlow Center for Biological Psychology, the Wiconsin National Primate Research Center, and the School of Medicine and Public Health, and rhesus brain PET studies performed at Madison in the early 1990s on the ECAT 931 human scanner are among the earliest in the literature. In August 2002 UW acquired a microPET P4, which has been used to acquire 1859 animal scans, including 1515 rhesus brain scans (as of 12/31/2009). Funding is requested for a microPET Focus 220 small animal positron emission tomography (PET) scanner built by Siemens Medical Solutions USA (Knoxville, TN). The Focus 220 provides improved spatial resolution (1.4 mm FWHM) and sensitivity (4%) along with a large field of view (19 cm transaxial and 7.6cm axial). This permits more detailed imaging of macaque brain with reduced tracer mass as well as simultaneous imaging of multiple rats or mice. In this resubmission, we note that the requested instrument is essential to ensure the continued capability to carry out NIH funded research. The vendor, Siemens, gave formal notification in July of 2009 that the end of support date for the P4 will be July 1, 2010 due to lack of availability of replacement components. This raises the possibility of losing use of the existing instrument in the near future. PUBLIC HEALTH RELEVANCE: Funding is requested for a small animal positron emission tomography (PET) scanner to replace existing equipment. This equipment will be used for longitudinal in vivo studies of animal models of human pathologies and imaging of fundamental biological processes. This will allow the UWMadison PET imaging program to continue to accommodate the increasing number of studies of pathologies such as mood disorders, fetal alcohol exposure, multiple sclerosis, and Parkinson's disease.