UW-Madison Small Animal PET: High Resolution Large Bore Tomograph

描述（由申请方提供）：正电子发射断层扫描（PET）用于人体疾病动物模型中潜在治疗的体内纵向研究。此外，小动物PET允许研究其他成像方式无法实现的基本生物过程。随着高分辨率专用小动物扫描仪的出现，该领域在过去几年中迅速发展。小动物PET已被用于各种各样的研究在威斯康星大学麦迪逊分校。华盛顿大学是哈洛生物心理学中心、威康辛国家灵长类动物研究中心和医学与公共卫生学院的猕猴聚居地，20世纪90年代初在麦迪逊使用ECAT 931人体扫描仪进行的恒河猴脑PET研究是文献中最早的研究之一。2002年8月，华盛顿大学获得了一台microPET P4，它已被用于获得1859次动物扫描，包括1515次恒河猴脑扫描（截至2009年12月31日）。西门子医疗解决方案美国公司（诺克斯维尔，田纳西州）建造的microPET Focus 220小动物正电子发射断层扫描仪需要资金。Focus 220提供了更高的空间分辨率（1.4 mm FWHM）和灵敏度（沿着）以及更大的视场（19 cm的轴向和7.6 cm的轴向）。这允许用减少的示踪剂质量对猕猴脑进行更详细的成像以及对多个大鼠或小鼠进行同时成像。在这份重新提交的文件中，我们注意到所要求的仪器对于确保继续开展NIH资助的研究的能力至关重要。供应商Siemens于2009年7月正式通知，由于缺乏可用的替换组件，P4的支持终止日期将为2010年7月1日。这就有可能在不久的将来不再使用现有文书。 公共卫生相关性：要求提供资金，以购买一台小型动物正电子发射断层扫描仪，以取代现有设备。该设备将用于人体病理学动物模型的纵向体内研究和基本生物过程的成像。这将使UWMadison PET成像计划继续适应越来越多的病理学研究，如情绪障碍，胎儿酒精暴露，多发性硬化症和帕金森病。

DESCRIPTION (provided by applicant): Positron emission tomography (PET) is used for in vivo longitudinal studies of potential therapies in animal models of human disease. Small animal PET moreover permits studies of fundamental biological processes that are not possible with other imaging modalities. With the advent of high resolution dedicated small animal scanners the field has grown rapidly in the last few years. Small animal PET has been used in a wide variety of studies at UW-Madison. UW is home to macaque colonies at the Harlow Center for Biological Psychology, the Wiconsin National Primate Research Center, and the School of Medicine and Public Health, and rhesus brain PET studies performed at Madison in the early 1990s on the ECAT 931 human scanner are among the earliest in the literature. In August 2002 UW acquired a microPET P4, which has been used to acquire 1859 animal scans, including 1515 rhesus brain scans (as of 12/31/2009). Funding is requested for a microPET Focus 220 small animal positron emission tomography (PET) scanner built by Siemens Medical Solutions USA (Knoxville, TN). The Focus 220 provides improved spatial resolution (1.4 mm FWHM) and sensitivity (4%) along with a large field of view (19 cm transaxial and 7.6cm axial). This permits more detailed imaging of macaque brain with reduced tracer mass as well as simultaneous imaging of multiple rats or mice. In this resubmission, we note that the requested instrument is essential to ensure the continued capability to carry out NIH funded research. The vendor, Siemens, gave formal notification in July of 2009 that the end of support date for the P4 will be July 1, 2010 due to lack of availability of replacement components. This raises the possibility of losing use of the existing instrument in the near future. PUBLIC HEALTH RELEVANCE: Funding is requested for a small animal positron emission tomography (PET) scanner to replace existing equipment. This equipment will be used for longitudinal in vivo studies of animal models of human pathologies and imaging of fundamental biological processes. This will allow the UWMadison PET imaging program to continue to accommodate the increasing number of studies of pathologies such as mood disorders, fetal alcohol exposure, multiple sclerosis, and Parkinson's disease.