Electronics Consoles for Biomolecular NMR

描述(由申请人提供)：总体目标是为佐治亚州和邻近地区的研究人员提供生物分子核磁共振波谱方面的尖端技术和能力，以进行NIH赞助的生物医学研究。对生物分子和生物分子系统的逐步、全面的研究需要结构和运动特征的原子级分辨率。这些都是现代生物分子核磁共振方法的强项。该提议是为佐治亚州的研究人员更换主力600和800 MHz核磁共振光谱仪上老化(12岁)、过时和越来越不可靠的电子控制台，这些光谱仪由核心、经常使用的核磁共振仪器组成，用于解决结构生物学的研究问题。仪器将由杰出的专家工作人员进行维护和管理，并存放在佐治亚大学的特殊设施中。一支经验丰富的咨询团队将继续指导和丰富设施运营，以确保设施的持续成功和生物医学研究人员的准入。将利用新仪器的新功能和改进的性能来处理各种重要的生物医学研究课题。这些问题包括蛋白质化学的一般问题、结构生物学、糖蛋白和糖生物学的方法发展、翻译后修饰、钙信号、膜-蛋白质相互作用、医学成像造影剂、内毒素-受体相互作用、细胞通讯、RNA结构和RNA-蛋白质相互作用。这些研究的结果将对人类健康问题，如败血症、病毒感染、癌症、免疫学、甲状腺疾病、囊性纤维化和许多其他问题具有重要意义。新仪器还将丰富我们的教育计划和下一代生物医学研究人员的教育经验，它将增强我们的核磁共振设备资源，提高设备的使用和效率，并将是持续、长期支持生物分子核磁共振和生物医学研究的不可或缺的组成部分。 公共卫生相关性：由所要求的仪器支持的生物医学研究正被用来解决与人类健康直接相关的许多至关重要的问题。这些疾病包括细菌和病毒感染、乳腺癌、甲状腺疾病和许多其他疾病。人们的期望是，从研究中获得的知识将影响新疗法和治疗的发展。

DESCRIPTION (provided by applicant): The overall goal is to provide leading edge technologies and capabilities in biomolecular NMR spectroscopy to investigators in Georgia and neighboring areas for NIH-sponsored biomedical research. Progressive, comprehensive studies of biomolecules and biomolecular systems require atomic level resolution of structural and motional features. These are a forte of modern biomolecular NMR methodologies. The proposal is to replace aging (12 year old), outdated and increasingly unreliable electronics consoles on the workhorse 600 and 800 MHz NMR spectrometers that comprise core, heavily used NMR instrumentation for investigators in Georgia for addressing research questions in structural biology. The instrumentation will be maintained and administered by outstanding expert staff and housed in exceptional facilities at the University of Georgia. An experienced advisory team will continue to guide and enrich facility operations to ensure continued facility success and access for biomedical researchers. New capabilities and improved performance of the new instrumentation will be exploited to tackle a diverse collection of important biomedical research topics. These include general issues in protein chemistry, methods development for structural biology, glycoproteins and glycobiology, post-translational modification, calcium signaling, membrane-protein interactions, contrast agents for medical imaging, endotoxin-receptor interactions, cellular communication, RNA structure and RNA-protein interactions. The results of these investigations will be important to human health issues such as sepsis, viral infection, cancer, immunology, thyroid disease, cystic fibrosis and many others. The new instrumentation will also enrich our educational programs and the educational experiences of the next generation of biomedical researchers, it will enhance our NMR facility resources and improve facility use and efficiency, and will be integral to continued, long-term support for biomolecular NMR and biomedical research. PUBLIC HEALTH RELEVANCE: The biomedical research supported by the requested instrumentation is being used to address many issues of fundamental importance directly relevant to human health. These include bacterial and viral infections, breast cancer, thyroid disease, and many others. The expectation is that the knowledge gained from the studies will influence development of new therapies and treatments.